公开(公告)号：US20190390192A1

公开(公告)日：2019-12-26

申请号：US16563233

申请日：2019-09-06

Applicant: iGenomX International Genomics Corporation

Inventor： Keith Brown

IPC: C12N15/10 ,  C12Q1/6874 ,  C12Q1/6806 ,  G16B30/00

Abstract: Rapid nucleic acid libraries, methods of generation, kits, and compositions relating to library synthesis, including reagents, intermediaries and final products are disclosed herein. The disclosure enables rapid synthesis of libraries that allow independent verification of sequence information and rapid identification of sequence information with template of origin.

公开(公告)号：US10450562B2

公开(公告)日：2019-10-22

申请号：US15509747

申请日：2015-09-09

Applicant: iGenomX International Genomics Corporation

Inventor： Keith Brown

IPC: C12N15/10 ,  G16B30/00 ,  C12Q1/6806 ,  C12Q1/6874 ,  C12Q1/6844 ,  C12Q1/686

Abstract: Rapid nucleic acid libraries, methods of generation, kits, and compositions relating to library synthesis, including reagents, intermediaries and final products are disclosed herein. The disclosure enables rapid synthesis of libraries that allow independent verification of sequence information and rapid identification of sequence information with template of origin.

公开(公告)号：US20170247689A1

公开(公告)日：2017-08-31

申请号：US15509747

申请日：2015-09-09

Applicant: iGenomX International Genomics Corporation

Inventor： Keith Brown

IPC: C12N15/10 ,  G06F19/22 ,  C12Q1/68

CPC classification number: C12N15/1093 ,  C12Q1/6806 ,  C12Q1/6844 ,  C12Q1/686 ,  C12Q1/6874 ,  G16B30/00 ,  C12Q2525/179 ,  C12Q2525/186 ,  C12Q2525/191 ,  C12Q2537/101 ,  C12Q2537/159 ,  C12Q2563/131

Abstract: Rapid nucleic acid libraries, methods of generation, kits, and compositions relating to library synthesis, including reagents, intermediaries and final products are disclosed herein. The disclosure enables rapid synthesis of libraries that allow independent verification of sequence information and rapid identification of sequence information with template of origin.

公开(公告)号：US20160376663A1

公开(公告)日：2016-12-29

申请号：US15121725

申请日：2015-02-27

Applicant: IGENOMX INTERNATIONAL GENOMICS CORPORATION

Inventor： Keith Brown

IPC: C12Q1/68 ,  G06F19/00 ,  A61K31/7072 ,  A61K31/7056 ,  A61K49/00 ,  A61K38/45

CPC classification number: C12Q1/6886 ,  A61K31/7056 ,  A61K31/7072 ,  A61K38/45 ,  A61K49/0054 ,  C12Q1/6809 ,  C12Q1/6869 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/178 ,  C12Y201/01 ,  G16H15/00 ,  Y02A90/26 ,  C12Q2525/161 ,  C12Q2525/179 ,  C12Q2525/185 ,  C12Q2525/191 ,  C12Q2535/122 ,  C12Q2537/165

Abstract: Methods and compositions related to the use of Mobile Element Insertions and their adjacent genomic sequences. Methods using MEIs as markers for cellular proliferation, as targets for pharmaceuticals, as markers for tissue fingerprinting and in related methods and compositions are disclosed herein. Methods and compositions relate to the detection, treatment and ongoing monitoring of cell proliferation events, cancer, and deleterious effects of mobile elements in aging, and to the selection, use and monitoring of the success of treatment regimens to address these conditions.

Abstract translation: 与使用移动元件插入物及其相邻基因组序列相关的方法和组合物。 使用MEI作为细胞增殖的标志物，作为药物的靶标，作为组织指纹图谱的标记物以及相关方法和组合物的方法在本文中公开。 方法和组成与检测，治疗和持续监测细胞增殖事件，癌症和移动因素在衰老中的有害作用以及治疗方案成功选择，使用和监测以解决这些病症有关。

公开(公告)号：US11214798B2

公开(公告)日：2022-01-04

申请号：US16563233

申请日：2019-09-06

Applicant: iGenomX International Genomics Corporation

Inventor： Keith Brown

IPC: C12N15/10 ,  C12Q1/6806 ,  C12Q1/6874 ,  C12Q1/6844 ,  C12Q1/686 ,  C40B40/06 ,  G16B30/00 ,  G16B30/20

Abstract: Rapid nucleic acid libraries, methods of generation, kits, and compositions relating to library synthesis, including reagents, intermediaries and final products are disclosed herein. The disclosure enables rapid synthesis of libraries that allow independent verification of sequence information and rapid identification of sequence information with template of origin.

公开(公告)号：US20160348169A1

公开(公告)日：2016-12-01

申请号：US15116404

申请日：2015-02-03

Applicant: iGenomX International Genomics Corporation

Inventor： Keith Brown ,  Peter Dansky

IPC: C12Q1/68 ,  C12N15/10

CPC classification number: C12Q1/6874 ,  C12N15/1093 ,  C12Q1/6811 ,  C12Q2521/301 ,  C12Q2535/122

Abstract: Disclosed herein are compositions and methods related to the elimination of molecules of a selected sequence from a nucleic acid sample or from an sequence dataset resulting from the sequencing of a sample, for example to exclude such molecules from downstream analysis or sequencing, or to exclude such sequences from a downstream data set.

Abstract translation: 本文公开了与从核酸样品或从样品测序得到的序列数据集中消除选定序列的分子相关的组合物和方法，例如从下游分析或测序中排除这些分子，或排除 来自下游数据集的序列。