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公开(公告)号：US20230212534A1
公开(公告)日：2023-07-06
申请号：US18085674
申请日：2022-12-21
发明人： Misha Golynskiy , Seth McDonald , Saurabh Nirantar , Matthew Kellinger , Michael Previte , Sergio Peisajovich , Molly He
CPC分类号： C12N9/1241 , C12N1/20
摘要： Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
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公开(公告)号：US20230047225A1
公开(公告)日：2023-02-16
申请号：US17829866
申请日：2022-06-01
发明人： Misha Golynskiy , Mariko Matsuura , Saurabh Nirantar , Hamed Tabatabaei Ghomi , Seth McDonald , Ryan Craig , Sergio Peisajovich , Kyrie Johnson , Kay Klausing , Eric Murtfeldt , Alexandra Exner
IPC分类号： C12N9/12 , C12Q1/6874
摘要： Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain low pre-phasing rates when using ambiently stored polymerases, as well as methods and kits using the same.
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公开(公告)号：US12104182B2
公开(公告)日：2024-10-01
申请号：US18120639
申请日：2023-03-13
发明人： Kay Klausing , Hamed Tabatabaei Ghomi , Misha Golynskiy , Saurabh Nirantar , Seth McDonald , Sergio Peisajovich
IPC分类号： C12N9/12
CPC分类号： C12N9/1252 , C12Y207/07007
摘要： Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
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公开(公告)号：US20230357731A1
公开(公告)日：2023-11-09
申请号：US18120639
申请日：2023-03-13
发明人： Kay Klausing , Hamed Tabatabaei Ghomi , Misha Golynskiy , Saurabh Nirantar , Seth McDonald , Sergio Peisajovich
IPC分类号： C12N9/12
CPC分类号： C12N9/1252 , C12Y207/07007
摘要： Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
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公开(公告)号：US11560552B2
公开(公告)日：2023-01-24
申请号：US17397003
申请日：2021-08-09
发明人： Misha Golynskiy , Seth McDonald , Saurabh Nirantar , Matthew Kellinger , Michael Previte , Sergio Peisajovich , Molly He
摘要： Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
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公开(公告)号：US20220056424A1
公开(公告)日：2022-02-24
申请号：US17397003
申请日：2021-08-09
发明人： Misha Golynskiy , Seth McDonald , Saurabh Nirantar , Matthew Kellinger , Michael Previte , Sergio Peisajovich , Molly He
IPC分类号： C12N9/12
摘要： Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
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公开(公告)号：US11634697B2
公开(公告)日：2023-04-25
申请号：US17226393
申请日：2021-04-09
发明人： Kay Klausing , Hamed Tabatabaei Ghomi , Misha Golynskiy , Saurabh Nirantar , Seth McDonald , Sergio Peisajovich
IPC分类号： C12N9/12
摘要： Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
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公开(公告)号：US20210348141A1
公开(公告)日：2021-11-11
申请号：US17226393
申请日：2021-04-09
发明人： Kay Klausing , Hamed Tabatabaei Ghomi , Misha Golynskiy , Saurabh Nirantar , Seth McDonald , Sergio Peisajovich
IPC分类号： C12N9/12
摘要： Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
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公开(公告)号：US20230383342A1
公开(公告)日：2023-11-30
申请号：US18325610
申请日：2023-05-30
申请人： Illumina Cambridge Limited , Illumina Singapore Pte. Ltd. , Illumina, Inc. , Illumina Software, Inc.
发明人： Xiaolin Wu , Patrick McCauley , Madushani Dharmarwardana , Saurabh Nirantar , Misha Golynskiy , Xiangyuan Yang , Ramesh Neelakandan , Benedict Mackworth , Carole Anastasi , Aathavan Karunakaran , Gery M. Vessere , David Bracher
IPC分类号： C12Q1/6869 , G01N21/64
CPC分类号： C12Q1/6869 , G01N2021/6439 , G01N2021/6419 , G01N21/6428
摘要： Embodiments of the present disclosure relate to kits, compositions, and methods for nucleic acid sequencing, for example, two-channel nucleic acid sequencing by synthesis using blue and green light excitation. In particular, unlabeled nucleotides for incorporation may be used in conjunction with affinity reagents containing detectable labels excitable by blue and/or green lights, for specific binding to each type of nucleotides incorporated.
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公开(公告)号：US11104888B2
公开(公告)日：2021-08-31
申请号：US16670876
申请日：2019-10-31
发明人： Misha Golynskiy , Seth McDonald , Saurabh Nirantar , Matthew Kellinger , Michael Previte , Sergio Peisajovich , Molly He
IPC分类号： C12N9/12
摘要： Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
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