-
公开(公告)号:US12104182B2
公开(公告)日:2024-10-01
申请号:US18120639
申请日:2023-03-13
发明人: Kay Klausing , Hamed Tabatabaei Ghomi , Misha Golynskiy , Saurabh Nirantar , Seth McDonald , Sergio Peisajovich
IPC分类号: C12N9/12
CPC分类号: C12N9/1252 , C12Y207/07007
摘要: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
-
公开(公告)号:US20230357731A1
公开(公告)日:2023-11-09
申请号:US18120639
申请日:2023-03-13
发明人: Kay Klausing , Hamed Tabatabaei Ghomi , Misha Golynskiy , Saurabh Nirantar , Seth McDonald , Sergio Peisajovich
IPC分类号: C12N9/12
CPC分类号: C12N9/1252 , C12Y207/07007
摘要: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
-
公开(公告)号:US11001816B2
公开(公告)日:2021-05-11
申请号:US16703569
申请日:2019-12-04
发明人: Kay Klausing , Hamed Tabatabaei Ghomi , Misha Golynskiy , Saurabh Nirantar , Seth McDonald , Sergio Peisajovich
IPC分类号: C12N9/12
摘要: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
-
公开(公告)号:US11634697B2
公开(公告)日:2023-04-25
申请号:US17226393
申请日:2021-04-09
发明人: Kay Klausing , Hamed Tabatabaei Ghomi , Misha Golynskiy , Saurabh Nirantar , Seth McDonald , Sergio Peisajovich
IPC分类号: C12N9/12
摘要: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
-
公开(公告)号:US20210348141A1
公开(公告)日:2021-11-11
申请号:US17226393
申请日:2021-04-09
发明人: Kay Klausing , Hamed Tabatabaei Ghomi , Misha Golynskiy , Saurabh Nirantar , Seth McDonald , Sergio Peisajovich
IPC分类号: C12N9/12
摘要: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
-
公开(公告)号:US20230047225A1
公开(公告)日:2023-02-16
申请号:US17829866
申请日:2022-06-01
发明人: Misha Golynskiy , Mariko Matsuura , Saurabh Nirantar , Hamed Tabatabaei Ghomi , Seth McDonald , Ryan Craig , Sergio Peisajovich , Kyrie Johnson , Kay Klausing , Eric Murtfeldt , Alexandra Exner
IPC分类号: C12N9/12 , C12Q1/6874
摘要: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain low pre-phasing rates when using ambiently stored polymerases, as well as methods and kits using the same.
-
公开(公告)号:US20240182881A1
公开(公告)日:2024-06-06
申请号:US18538262
申请日:2023-12-13
申请人: ILLUMINA, INC.
发明人: Dewei Joel Toh , Leslie Yee Ming Beh , Shu Ting Tan , Anna Traczyk , Saurabh Nirantar , Eric Brustad , Hamed Tabatabaei Ghomi , Zahra Fahmi , Lekha Ravichandraprabhu , Colin Brown , Kayla Busby , Stephen Gross , Rebekah Karadeema , Huy Lam , Pascale Mathonet , Sarah E. Shultzaberger , Kathleen Tzeng , Allison Kathleen Yunghans
IPC分类号: C12N9/78
CPC分类号: C12N9/78 , C12Y305/04005
摘要: The present disclosure is concerned with proteins, methods, compositions, and kits for mapping of methylation status of nucleic acids, including 5-methylcytosine and 5-hydroxymethyl cytosine (5 hmC). In one embodiment, proteins are provided that selectively act on certain modified cytosines of target nucleic acids and converts them to thymidine or modified thymidine analogues. In another embodiment, proteins are provided that selectively act on certain modified cytosines of target nucleic acids and converts them to uracil or thymidine and selectively do not act on other certain modified cytosines of target nucleic acids. Also provided are compositions and kits that include one or more of the proteins and methods for using one or more of the proteins.
-
公开(公告)号:US12077789B2
公开(公告)日:2024-09-03
申请号:US17829866
申请日:2022-06-01
申请人: ILLUMINA, INC.
发明人: Misha Golynskiy , Mariko Matsuura , Saurabh Nirantar , Hamed Tabatabaei Ghomi , Seth McDonald , Ryan Craig , Sergio Peisajovich , Kyrie Johnson , Kay Klausing , Eric Murtfeldt , Alexandra Exner
IPC分类号: C12N9/12 , C12Q1/6874
CPC分类号: C12N9/1252 , C12Q1/6874 , C12Y207/07007
摘要: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain low pre-phasing rates when using ambiently stored polymerases, as well as methods and kits using the same.
-
公开(公告)号:US20240141427A1
公开(公告)日:2024-05-02
申请号:US18373620
申请日:2023-09-27
申请人: ILLUMINA, INC.
发明人: Misha Golynskiy , Rahman Rahman Pour , Jiawen Li , Ryan Craig , Hamed Tabatabaei Ghomi , Saurabh Nirantar , Hsu Myat Noe , Lin Hui Chang , Yvonne Devadas , Jing Wen Lim , Kay Klausing , Humberto Rojo , Eric Murtfeldt , Chris Garcia
IPC分类号: C12Q1/6874 , C12N9/12
CPC分类号: C12Q1/6874 , C12N9/1252 , C12Y207/07007
摘要: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain low error rate, low phasing rate, or increased incorporation rate for a second generation ffN under reduced incorporation times, as well as methods and kits using the same.
-
-
-
-
-
-
-
-