公开(公告)号：US20220204936A1

公开(公告)日：2022-06-30

申请号：US17475794

申请日：2021-09-15

Applicant: Industrial Technology Research Institute

Inventor： Yu-Bing LIOU ,  Chih-Ching LIAO ,  Hsin-Yi HSU ,  Ying-Wen SHEN ,  Yun-Chung TENG ,  Hsin-Hsin SHEN ,  Yi-Chen CHEN

IPC: C12N5/077 ,  C08J5/18

Abstract: A non-fibrous film of which the composition includes a collagen and a polyester polymer is provided. A content of the polyester polymer in the non-fibrous film is 1-60 wt %. Moreover, the non-fibrous film has a swelling rate of 1-200 μm/hour or a swelling proportion per unit time of 0.1-2%/hour in an aqueous liquid.

公开(公告)号：US20220204772A1

公开(公告)日：2022-06-30

申请号：US17561133

申请日：2021-12-23

Applicant: Industrial Technology Research Institute

Inventor： Yun-Chung TENG ,  Jen-Huang HUANG ,  Ying-Wen SHEN ,  Yu-Bing LIOU ,  Hsin-Yi HSU ,  Li-Hsin LIN ,  Yuchi WANG ,  Hsin-Hsin SHEN

IPC: C08L89/06 ,  C08J3/24 ,  A61L27/52 ,  A61L27/26 ,  C12N5/00 ,  B33Y80/00

Abstract: A bioprintable material is provided. The bioprintable material includes a hydrogel and microfilaments mixed in the hydrogel. The hydrogel includes a first collagen. The microfilament includes a second collagen. The diameter of the microfilament is ranging from 5 microns to 200 microns. The weight ratio of the microfilaments to the first collagen is ranging from 0.01:1 to 10:1.

公开(公告)号：US20210196626A1

公开(公告)日：2021-07-01

申请号：US16731966

申请日：2019-12-31

Applicant: Industrial Technology Research Institute

Inventor： Yu-Bing LIOU ,  Hsin-Yi HSU ,  Ying-Wen SHEN ,  Yun-Chung TENG ,  Yuchi WANG ,  Hsin-Hsin SHEN

IPC: A61K9/00 ,  A61K47/42 ,  A61K47/32 ,  A61K47/34

Abstract: An ophthalmic drug delivery device and a method for fabricating the same are provided. The ophthalmic drug delivery device includes a shield element and a drug release element. The shield element has a light transmittance more than or equal to 80%. The drug release element is an annular body so that the drug release element surrounds the shield element. The drug release element is neutral and includes a cross-linked neutral collagen, a first hydrophilic biodegradable polymer and a drug. The shield element is acidic and includes a cross-linked acidic collagen and a second hydrophilic biodegradable polymer.