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公开(公告)号：US20170172686A1
公开(公告)日：2017-06-22
申请号：US15211141
申请日：2016-07-15
发明人： Yu-Bing LIOU , Hsiu-Ying WANG , Hsin-Yi HSU , Wei-Li CHEN , Chin-Tsung HUANG , Hsin-Hsin SHEN
CPC分类号： A61B90/04 , A61B2090/0427 , A61B2090/0445 , A61B2090/0472 , A61B2090/08021 , A61F9/00745 , A61L27/16 , A61L27/18 , A61L27/24 , A61L31/044 , A61L31/048 , A61L31/06 , A61L31/129 , A61L2430/16 , C08L71/02 , C08L39/06
摘要： According to embodiments, a membrane with a flat or curved surface is provided for protection of intraocular tissues. The membrane can be used to cover the cornea for protecting corneal endothelial cells, to cover the anterior and posterior surface of the iris, or to cover the surface of the posterior capsule for separating the intraocular tissues. The membrane has a layered structure, which is composed of a collagen and a hydrophilic biopolymer or an organic polymer material. In particular, the membrane has high transparency and high water retention in a wet state.
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公开(公告)号：US20220204772A1
公开(公告)日：2022-06-30
申请号：US17561133
申请日：2021-12-23
发明人： Yun-Chung TENG , Jen-Huang HUANG , Ying-Wen SHEN , Yu-Bing LIOU , Hsin-Yi HSU , Li-Hsin LIN , Yuchi WANG , Hsin-Hsin SHEN
摘要： A bioprintable material is provided. The bioprintable material includes a hydrogel and microfilaments mixed in the hydrogel. The hydrogel includes a first collagen. The microfilament includes a second collagen. The diameter of the microfilament is ranging from 5 microns to 200 microns. The weight ratio of the microfilaments to the first collagen is ranging from 0.01:1 to 10:1.
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公开(公告)号：US20170106125A1
公开(公告)日：2017-04-20
申请号：US15294047
申请日：2016-10-14
发明人： Yu-Chi WANG , Hsin-Hsin SHEN , Chin-Fu CHEN , Meng-Yow HSIEH , Sen-Lu CHEN , Yu-Bing LIOU , Tsai-Yu LIN , Pei-Shan LI , Wei-Lin YU
CPC分类号： A61L31/145 , A61L31/041 , A61L31/048 , A61L31/14 , A61L2400/06 , C08L29/04
摘要： The present disclosure provides a hydrogel composition including: a hydrogel having a structure represented by Formula (I) or Formula (II) shown as follows: A-B-BOX-B-A, Formula (I); B-A-B-(BOX-BAB)n-BOX-B-A-B, Formula (II), wherein, A is a hydrophilic polyethylene glycol polymer, B is a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2,2′-Bis(2-oxazoline) for coupling di-block of A-B or tri-block of B-A-B, and n is an integer greater than or equal to 0; and an anti-adhesion additive, wherein the anti-adhesion additive comprises a carbohydrate, a nitrogen-containing cyclic compound, a polymer or a combination thereof.
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公开(公告)号：US20140161842A1
公开(公告)日：2014-06-12
申请号：US13870178
申请日：2013-04-25
发明人： Li-Hsin LIN , Hsin-Hsin SHEN , Ying-Hsueh CHAO , Hsiu-Hua HUANG , Yu-Bing LIOU , Chih-Bing HUNG , Chin-Fu CHEN
CPC分类号： A61L27/26 , A61K9/006 , A61K9/70 , A61K9/7007 , A61L27/54 , A61L27/56 , A61L27/58 , C08L67/04 , C08L71/02
摘要： A bioresorbable porous film, including a blend mixture of polylactic acid and at least two kinds of polyethylene glycol, wherein the at least two kinds of polyethylene glycol include a first polyethylene glycol, which is in a solid form under ambient temperature and atmospheric pressure, and a second polyethylene glycol, which is in a liquid form under ambient temperature and atmospheric pressure is provided. The film has a porosity of 10%-90%.
摘要翻译： 一种生物可吸收多孔膜，其包括聚乳酸和至少两种聚乙二醇的混合物，其中所述至少两种聚乙二醇包括在环境温度和大气压下为固体形式的第一聚乙二醇，以及 提供在环境温度和大气压下为液体形式的第二聚乙二醇。 该膜的孔隙率为10％-90％。
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公开(公告)号：US20220388293A1
公开(公告)日：2022-12-08
申请号：US17885874
申请日：2022-08-11
发明人： Hsin-Hsin SHEN , Yu-Chi WANG , Ming-Chia YANG , Yu-Bing LIOU , Wei-Hong CHANG , Yun-Han LIN , Hsin-Yi HSU , Yun-Chung TENG , Chia-Jung LU , Yi-Hsuan LEE , Jian-Wei LIN , Kun-Mao KUO , Ching-Mei CHEN
摘要： A method for preparing a bifunctional film, including: (a) drying a first polymer solution to form a film to form an anti-adhesion layer, and (b) drying a second polymer solution over the anti-adhesion layer to form a film to form an attachment layer. The first polymer solution includes a first hydrophobic solution and a first hydrophilic solution, and in the first polymer solution, the weight ratio of the solute of the first hydrophobic solution to the solute of the first hydrophilic solution is 1:0.01-1. Moreover, the second polymer solution is composed of a second hydrophilic solution.
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公开(公告)号：US20220204936A1
公开(公告)日：2022-06-30
申请号：US17475794
申请日：2021-09-15
发明人： Yu-Bing LIOU , Chih-Ching LIAO , Hsin-Yi HSU , Ying-Wen SHEN , Yun-Chung TENG , Hsin-Hsin SHEN , Yi-Chen CHEN
摘要： A non-fibrous film of which the composition includes a collagen and a polyester polymer is provided. A content of the polyester polymer in the non-fibrous film is 1-60 wt %. Moreover, the non-fibrous film has a swelling rate of 1-200 μm/hour or a swelling proportion per unit time of 0.1-2%/hour in an aqueous liquid.
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公开(公告)号：US20200247101A1
公开(公告)日：2020-08-06
申请号：US16675838
申请日：2019-11-06
发明人： Hsin-Hsin SHEN , Yu-Chi WANG , Ming-Chia YANG , Yu-Bing LIOU , Wei-Hong CHANG , Yun-Han LIN , Hsin-Yi HSU , Yun-Chung TENG , Chia-Jung LU , Yi-Hsuan LEE , Jian-Wei LIN , Kun-Mao KUO , Ching-Mei CHEN
摘要： A method for preparing a bifunctional film, including: (a) drying a first polymer solution to form a film to form an anti-adhesion layer; and (b) drying a second polymer solution over the anti-adhesion layer to form a film to form an attachment layer. The first polymer solution includes a first hydrophobic solution and a first hydrophilic solution, and in the first polymer solution, the weight ratio of the solute of the first hydrophobic solution to the solute of the first hydrophilic solution 1:0.01-1. Moreover, the second polymer solution consists of a second hydrophilic solution.
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公开(公告)号：US20210196626A1
公开(公告)日：2021-07-01
申请号：US16731966
申请日：2019-12-31
发明人： Yu-Bing LIOU , Hsin-Yi HSU , Ying-Wen SHEN , Yun-Chung TENG , Yuchi WANG , Hsin-Hsin SHEN
摘要： An ophthalmic drug delivery device and a method for fabricating the same are provided. The ophthalmic drug delivery device includes a shield element and a drug release element. The shield element has a light transmittance more than or equal to 80%. The drug release element is an annular body so that the drug release element surrounds the shield element. The drug release element is neutral and includes a cross-linked neutral collagen, a first hydrophilic biodegradable polymer and a drug. The shield element is acidic and includes a cross-linked acidic collagen and a second hydrophilic biodegradable polymer.
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公开(公告)号：US20190076234A1
公开(公告)日：2019-03-14
申请号：US16122438
申请日：2018-09-05
发明人： Yu-Bing LIOU , Ming-Chia YANG , Hsin-Yi HSU , Yun-Han LIN , Wei-Hong CHANG , I-Jong WANG , Hsin-Hsin SHEN
摘要： An implanting device is used for implanting a membrane in a biological tissue. The implanting device includes a sleeve, a membrane storage element, an injection element and a bubble generating element. The membrane storage element is fixed at the sleeve. The injection element is inserted in the sleeve and the membrane storage element, and includes a capturing end and connecting end. The capturing end is for capturing the membrane and has a hole. The bubble generating element is connected to the connecting end, and is for providing a gas that is then outputted via the hole. By the rotation of the injection element, the capturing end extends straight out of the membrane storage element or retracts straight into the membrane storage element.
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公开(公告)号：US20140187591A1
公开(公告)日：2014-07-03
申请号：US13871491
申请日：2013-04-26
发明人： Hsin-Hsin SHEN , Yu-Bing LIOU , Chin-Fu CHEN , Li-Hsin LIN , Hsiu-Hua HUANG , Ying-Hsueh CHAO , Meng-Yow HSIEH , Miao-Tzu CHEN , Chih-Bing HUNG
IPC分类号： A61L27/54
CPC分类号： A61K47/34 , A61K9/0024
摘要： The disclosure provides a solid form and a method for preparing the same. The solid form consists essentially of a biodegradable copolymer and an amide-containing compound. The biodegradable copolymer is semi-crystalline due to the dipole-dipole interaction between the biodegradable copolymer and the urea. The method for preparing the above solid form includes: dissolving a biodegradable copolymer and an amide-containing compound in water at a first temperature, obtaining a solution; cooling the solution at a second temperature to form a solid mixture; and the solid mixture is subjected to a freeze-drying process at a third temperature.
摘要翻译： 本公开提供了一种固体形式及其制备方法。 固体形式基本上由可生物降解的共聚物和含酰胺的化合物组成。 由于可生物降解的共聚物和尿素之间的偶极 - 偶极相互作用，生物降解性共聚物是半结晶的。 制备上述固体形式的方法包括：在第一温度下将可生物降解的共聚物和含酰胺的化合物溶解在水中，得到溶液; 在第二温度下冷却溶液以形成固体混合物; 并将固体混合物在第三温度下进行冷冻干燥处理。
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