公开(公告)号：US11383038B2

公开(公告)日：2022-07-12

申请号：US16140186

申请日：2018-09-24

Applicant: Insulet Corporation

Inventor： David Nazzaro ,  Ian McLaughlin ,  Maureen McCaffrey ,  Simon Kozin ,  Jackie Mac

IPC: A61M5/20 ,  A61M5/315 ,  A61M5/158 ,  A61M5/145 ,  A61M5/142 ,  A61M5/00 ,  A61M5/28 ,  A61M5/24

Abstract: A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can be controlled to provide the liquid drug to the patient in a single dose or over multiple doses.

公开(公告)号：US10780217B2

公开(公告)日：2020-09-22

申请号：US15809491

申请日：2017-11-10

Applicant: Insulet Corporation

Inventor： David Nazzaro ,  Simon Kozin ,  Maureen McCaffrey

IPC: A61M5/145 ,  A61M5/142 ,  A61M5/168 ,  A61M5/315

Abstract: Ratchet-based drive systems for more reliable and safer drug delivery are provided. The ratchet-based drive systems restrict angular movement and/or linear movement of components that cause a plunger to expel a liquid drug from a drug container. Movement of the components can be restricted to correspond to a predetermined or desired portion of the liquid drug. In the case that control of the drive system is lost or fails, the maximum amount of drug that could be delivered is limited to a known amount, thereby reducing the likelihood of an overdose.

公开(公告)号：US20170340827A1

公开(公告)日：2017-11-30

申请号：US15607169

申请日：2017-05-26

Applicant: Insulet Corporation

Inventor： David Nazzaro ,  Ian McLaughlin ,  Simon Kozin ,  Maureen McCaffrey ,  Jackie Mac ,  Alexander Doudoumopoulus ,  Bhavin Patel

IPC: A61M5/315 ,  A61M5/28 ,  A61M5/31 ,  A61M37/00

CPC classification number: A61M5/31593 ,  A61M5/14248 ,  A61M5/28 ,  A61M5/31531 ,  A61M5/32 ,  A61M5/42 ,  A61M37/00 ,  A61M2005/2474 ,  A61M2005/3142 ,  A61M2005/31518

Abstract: A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can be controlled to provide the liquid drug to the patient in a single dose or over multiple doses.

公开(公告)号：US11672917B2

公开(公告)日：2023-06-13

申请号：US17039570

申请日：2020-09-30

Applicant: Insulet Corporation

Inventor： Steven Cardinali ,  David Nazzaro ,  Daniel Allis ,  Maureen McCaffrey

IPC: A61M5/315

CPC classification number: A61M5/31576 ,  A61M5/315 ,  A61M5/31501 ,  A61M5/31535 ,  A61M5/31566 ,  A61M5/31593 ,  A61M5/31511 ,  A61M5/31533 ,  A61M5/31543

Abstract: Drive systems for a drug delivery device are provided. The drive systems can be positioned within a container that stores a liquid drug to be delivered to a user. The drive systems can be coupled to a plunger positioned within the container. The drive systems can be incrementally advanced to drive the plunger further into the container, thereby expelling a portion of the stored liquid drug from the container for delivery to the user. The container can be any type of container including a pre-filled, standardized drug cartridge. The drive systems and container can be components of a wearable drug delivery device.

公开(公告)号：US11633541B2

公开(公告)日：2023-04-25

申请号：US16794689

申请日：2020-02-19

Applicant: Insulet Corporation

Inventor： Maureen McCaffrey ,  David Nazzaro ,  Ian McLaughlin ,  Simon Kozin

IPC: A61M37/00 ,  A61M5/28 ,  A61M5/24 ,  A61M5/34 ,  A61M5/32 ,  A61M5/315 ,  A61M5/142 ,  A61J1/20

Abstract: Drug delivery systems with reduced hold-up volumes are provided. The drug delivery systems include a cartridge configured to hold a liquid drug. A cartridge stopper is positioned in a first portion of the cartridge. A needle guide component is positioned within the cartridge stopper. A needle is positioned within a central opening of the needle guide. A plunger is positioned in a second portion of the cartridge. The plunger includes a fluid path pocket facing and aligned with the central opening of the needle guide component. The plunger is driven toward the cartridge stopper to expel the liquid drug from the cartridge through the needle. An end of the needle can be positioned within the fluid path pocket when the plunger is pushed against the cartridge stopper, ensuring that only a small volume of the liquid drug remains in the cartridge when delivery of the liquid drug is completed.

公开(公告)号：US20170189270A1

公开(公告)日：2017-07-06

申请号：US15398657

申请日：2017-01-04

Applicant: INSULET CORPORATION

Inventor： David Nazzaro ,  Maureen McCaffrey ,  Robert F. Rioux ,  Michael Philip Graffeo ,  Ian McLaughlin ,  Nicholas Jansky ,  Sam Rosenblum ,  David Clare ,  Robert D. Schaefer ,  Daniel P. Allis ,  Bryan Dillon ,  Steven Barletta ,  Bryan Choate ,  Raymond Dobry ,  John LeFavour

IPC: A61J1/20 ,  A61J1/14

CPC classification number: A61M5/1782 ,  A61M5/321 ,  A61M2005/3109 ,  A61M2005/3267 ,  A61M2205/6045

Abstract: Systems, components, and methods are disclosed for withdrawing drug from a liquid drug container and transferring drug to a medical device. One or more components may have keying features so that only the correct liquid drug container and medical device are accessed, making sure the medical device is filled with the correct drug. A syringe needle hub may have keying features corresponding to keying features on a cap on the liquid drug container and on the medical device. An alignment device facilitates easy-to-operate filling of a medical device. The alignment device aligns a liquid drug container over a fill port of the medical device and can include components for moving the liquid drug container into engagement with the medical device and for automatically initiating drug transfer to the medical device. A retractable skirt or needle cover protects the needle and is unlocked only when the skirt or needle cover is close to or touching the medical device.

公开(公告)号：US11129943B2

公开(公告)日：2021-09-28

申请号：US15980469

申请日：2018-05-15

Applicant: Insulet Corporation

Inventor： David Nazzaro ,  Ian McLaughlin ,  Simon Kozin ,  Maureen McCaffrey ,  Jackie Mac ,  Alexander Doudoumopoulos ,  Bhavin Patel

IPC: A61M5/315 ,  A61M5/142 ,  A61M5/28 ,  A61M5/32 ,  A61M5/24 ,  A61M37/00 ,  A61M5/31 ,  A61M5/42

Abstract: A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can be controlled to provide the liquid drug to the patient in a single dose or over multiple doses.

公开(公告)号：US10342926B2

公开(公告)日：2019-07-09

申请号：US15607169

申请日：2017-05-26

Applicant: Insulet Corporation

Inventor： David Nazzaro ,  Ian McLaughlin ,  Simon Kozin ,  Maureen McCaffrey ,  Jackie Mac ,  Alexander Doudoumopoulos ,  Bhavin Patel

IPC: A61M5/24 ,  A61M5/28 ,  A61M5/31 ,  A61M5/32 ,  A61M5/42 ,  A61M37/00 ,  A61M5/142 ,  A61M5/315

Abstract: A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can be controlled to provide the liquid drug to the patient in a single dose or over multiple doses.

公开(公告)号：USD851752S1

公开(公告)日：2019-06-18

申请号：US29671670

申请日：2018-11-29

Applicant: Insulet Corporation

Designer： David Nazzaro ,  Jeff Barnes ,  Maureen McCaffrey ,  Melinda Freson ,  Alexander Patt Broerman

公开(公告)号：US20170340837A1

公开(公告)日：2017-11-30

申请号：US15607182

申请日：2017-05-26

Applicant: Insulet Corporation

Inventor： David Nazzaro ,  Ian McLaughlin ,  Simon Kozin ,  Maureen McCaffrey ,  Jackie Mac ,  Alexander Doudoumopoulus ,  Bhavin Patel

IPC: A61M5/315 ,  A61M5/28 ,  A61M5/42 ,  A61M5/32 ,  A61M5/31 ,  A61M37/00

CPC classification number: A61M5/31531 ,  A61M5/14248 ,  A61M5/28 ,  A61M5/31593 ,  A61M5/32 ,  A61M5/42 ,  A61M37/00 ,  A61M2005/2474 ,  A61M2005/3142 ,  A61M2005/31518

Abstract: A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can be controlled to provide the liquid drug to the patient in a single dose or over multiple doses.