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公开(公告)号：US20230331988A1
公开(公告)日：2023-10-19
申请号：US18333173
申请日：2023-06-12
发明人： Nathaniel H. Park , James L. Hedrick , Victoria A. Piunova , Gavin Jones , Yi Yan Yang , Pang Kern Jeremy Tan , Chuan Yang , Cherylette Anne Alexander
IPC分类号： C08L79/02
摘要： Techniques regarding guanidinium functionalized polylysine polymers that can have antimicrobial and/or anticancer activity are provided. For example, one or more embodiments described herein can comprise a chemical composition, which can comprise a polymer comprising a molecular backbone covalently bonded to a pendent guanidinium functional group, wherein the molecular backbone can comprise a polylysine structure.
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公开(公告)号：US11174289B1
公开(公告)日：2021-11-16
申请号：US16880280
申请日：2020-05-21
发明人： Payel Das , Flaviu Cipcigan , James L. Hedrick , Yi Yan Yang , Kahini Wadhawan , Inkit Padhi , Enara C Vijil , Pang Kern Jeremy Tan
摘要： De novo, artificial intelligence (AI) designed antimicrobial peptides (AMPs), antibacterial products comprising the AMPs and methods for treating bacterial infections using the products are provided. In one or more embodiments, the AMPs were designed using conditional latent attribute space sampling (CLaSS). The AMPs comprise up to twenty natural amino acids in length, including one with twelve and another with thirteen natural amino acids in length. The AMPs demonstrate low-toxicity and show high antimicrobial potency against diverse pathogens including multi-medication-resistant Gram negative Klebsiella pneumoniae.
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公开(公告)号：US10653142B2
公开(公告)日：2020-05-19
申请号：US15839270
申请日：2017-12-12
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Chuan Yang , Yi Yan Yang
摘要： Techniques regarding polymers with antimicrobial functionality are provided. For example, one or more embodiments described herein can regard a polymer, which can comprise a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further, the repeating ionene unit can have antimicrobial functionality.
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公开(公告)号：US20210363183A1
公开(公告)日：2021-11-25
申请号：US16880280
申请日：2020-05-21
发明人： Payel Das , Flaviu Cipcigan , James L. Hedrick , Yi Yan Yang , Kahini Wadhawan , Inkit Padhi , Enara C Vijil , Pang Kern Jeremy Tan
IPC分类号： C07K7/08
摘要： De novo, artificial intelligence (AI) designed antimicrobial peptides (AMPs), antibacterial products comprising the AMPs and methods for treating bacterial infections using the products are provided. In one or more embodiments, the AMPs were designed using conditional latent attribute space sampling (CLaSS). The AMPs comprise up to twenty natural amino acids in length, including one with twelve and another with thirteen natural amino acids in length. The AMPs demonstrate low-toxicity and show high antimicrobial potency against diverse pathogens including multi-medication-resistant Gram negative Klebsiella pneumoniae.
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公开(公告)号：US11028264B2
公开(公告)日：2021-06-08
申请号：US16531432
申请日：2019-08-05
发明人： Nathaniel H. Park , James L. Hedrick , Victoria A. Piunova , Gavin Jones , Yi Yan Yang , Pang Kern Jeremy Tan , Chuan Yang , Cherylette Anne Alexander
摘要： Techniques regarding guanidinium functionalized polylysine polymers that can have antimicrobial and/or anticancer activity are provided. For example, one or more embodiments described herein can comprise a chemical composition, which can comprise a polymer comprising a molecular backbone covalently bonded to a pendent guanidinium functional group, wherein the molecular backbone can comprise a polylysine structure.
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公开(公告)号：US10667514B2
公开(公告)日：2020-06-02
申请号：US15839415
申请日：2017-12-12
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Chuan Yang , Yi Yan Yang
IPC分类号： A01N25/04 , A01N25/10 , A01N27/00 , A01N33/04 , A01N43/08 , A01N47/30 , A01N37/02 , A01N33/12 , A61Q17/00
摘要： Techniques regarding amine monomers that can form ionene compositions with antimicrobial functionality are provided. For example, one or more embodiments described herein can comprise a monomer, which can comprise a molecular backbone. The molecular backbone can comprise a norspermidine structure. The norspermidine structure can comprise a tertiary amino group. Also, the tertiary amino group can comprise a functional group, and an amino group of the norspermidine structure can be capable of being ionized.
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公开(公告)号：US20190174755A1
公开(公告)日：2019-06-13
申请号：US15839388
申请日：2017-12-12
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Yi Yan Yang , Mu San Zhang
CPC分类号： A01N37/18 , A01N33/12 , A01N43/50 , C08G69/40 , C08G2230/00 , C08L101/00 , A01N25/10
摘要： Techniques regarding ionene and/or polyionene compositions with antimicrobial functionality and enhanced hydrophilicity are provided. For example, one or more embodiments can regard a chemical compound that can comprise an ionene unit, which can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. The ionene unit can have antimicrobial functionality. Further, the chemical compound can comprise a hydrophilic functional group covalently bonded to the ionene unit. Also, the chemical compound can have carbohydrate mimetic functionality.
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公开(公告)号：US20190174747A1
公开(公告)日：2019-06-13
申请号：US15839402
申请日：2017-12-12
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Yi Yan Yang
摘要： Techniques regarding chemical compounds with antimicrobial functionality are provided. For example, one or more embodiments describe herein can comprise a monomer that can comprise a molecular backbone. The molecular backbone can comprise a bis(urea)guanidinium structure covalently bonded to a functional group, which can comprise a radical. Also, the monomer can have supramolecular assembly functionality.
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公开(公告)号：US20220009966A1
公开(公告)日：2022-01-13
申请号：US17487225
申请日：2021-09-28
发明人： Payel Das , Flaviu Cipcigan , James L. Hedrick , Yi Yan Yang , Kahini Wadhawan , Inkit Padhi , Enara C Vijil , Pang Kern Jeremy Tan
IPC分类号： C07K7/08
摘要： De novo, artificial intelligence (AI) designed antimicrobial peptides (AMPs), antibacterial products comprising the AMPs and methods for treating bacterial infections using the products are provided. In one or more embodiments, the AMPs were designed using conditional latent attribute space sampling (CLaSS). The AMPs comprise up to twenty natural amino acids in length, including one with twelve and another with thirteen natural amino acids in length. The AMPs demonstrate low-toxicity and show high antimicrobial potency against diverse pathogens including multi-medication-resistant Gram negative Klebsiella pneumoniae.
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公开(公告)号：US11006628B2
公开(公告)日：2021-05-18
申请号：US16744868
申请日：2020-01-16
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Yi Yan Yang
IPC分类号： A01N25/10 , A01N37/26 , A01N43/50 , A01N47/44 , C07C279/10 , C08L79/02 , C08G69/26 , C08G73/02 , C08L101/00 , A61Q17/00
摘要： Techniques regarding chemical compounds with antimicrobial functionality are provided. For example, one or more embodiments describe herein can comprise a monomer that can comprise a molecular backbone. The molecular backbone can comprise a bis(urea)guanidinium structure covalently bonded to a functional group, which can comprise a radical. Also, the monomer can have supramolecular assembly functionality.
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