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公开(公告)号：US12128063B2
公开(公告)日：2024-10-29
申请号：US17494708
申请日：2021-10-05
IPC分类号： A61K31/795 , A61P31/14 , C08G64/02
CPC分类号： A61K31/795 , A61P31/14 , C08G64/025
摘要： A water-soluble polymer having an aliphatic polycarbonate backbone, a first carbonate monomer with at least one hydrophilic functionality, and a second carbonate monomer with at least one hydrophobic functionality is able to completely and quickly eliminate a virus from a human and/or animal cell. The at least one hydrophilic functionality is a sulfate, a sulfonate, a carboxylate, and/or a phosphate and the at least one hydrophobic functionality is an alkyl. The hydrophilic/hydrophobic functionalities of the polymer may be tuned to enhance the antiviral properties of the polymer and/or to decrease any cytotoxicity associated with the application of the polymer to a human and/or animal cell. The antiviral polymer is biocompatible and biodegradable.
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公开(公告)号：US11690380B2
公开(公告)日：2023-07-04
申请号：US16686111
申请日：2019-11-16
发明人： Willy Chin , James L. Hedrick , Nor Lizawati Ibrahim , Ashlynn L. Z. Lee , Robert J. Ono , Qingxing Xu , Yi Yan Yang
IPC分类号： A01N47/44 , C08G64/42 , C08G18/38 , C08G64/02 , C08G18/48 , C08G18/66 , C08G18/73 , C08G18/75 , C08G64/30
CPC分类号： A01N47/44 , C08G18/3819 , C08G18/3831 , C08G18/4833 , C08G18/6681 , C08G18/73 , C08G18/755 , C08G64/0241 , C08G64/30 , C08G64/42 , A01N47/44 , A01N25/10
摘要： Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.
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公开(公告)号：US11617367B2
公开(公告)日：2023-04-04
申请号：US17215700
申请日：2021-03-29
发明人： James L. Hedrick , Mareva B. Fevre , Nathaniel H. Park , Victoria A. Piunova , Yi Yan Yang , Pang Kern Jeremy Tan
IPC分类号： A01N25/10 , A01N37/26 , A01N43/50 , A01N47/44 , C07C279/10 , C08L79/02 , C08G69/26 , C08G73/02 , C08L101/00 , A61Q17/00
摘要： Techniques regarding chemical compounds with antimicrobial functionality are provided. For example, one or more embodiments describe herein can comprise a monomer that can comprise a molecular backbone. The molecular backbone can comprise a bis(urea)guanidinium structure covalently bonded to a functional group, which can comprise a radical. Also, the monomer can have supramolecular assembly functionality.
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公开(公告)号：US20210363296A1
公开(公告)日：2021-11-25
申请号：US16882028
申请日：2020-05-22
发明人： Nathaniel H. Park , Victoria A. Piunova , Dmitry Zubarev , James L. Hedrick , Yi Yan Yang , Eddy Wei Ping Tan
摘要： Techniques regarding post polymerization modifications to polycarbonate polymers via a flow reactor are provided. For example, one or more embodiments described herein can comprise a cyclic carbonate monomer that can be employed to facilitate polymerization of one or more polycarbonate platforms susceptible to post polymerization modification. For instance, one or more embodiments can regard a cyclic carbonate molecular backbone covalently bonded to an aryl halide functional group via in accordance with a chemical structure selected from the group consisting of: In the chemical structures, “R1” can be selected from the group consisting of a hydrogen atom and a functional group comprising a first alkyl group; “L” can represent a linkage group, comprising: a second alkyl group and an end group having at least one member selected from the group consisting of an oxygen atom and a nitrogen atom; and “A” can represent the aryl halide functional group.
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公开(公告)号：US20210289782A1
公开(公告)日：2021-09-23
申请号：US17335643
申请日：2021-06-01
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Chuan Yang , Yi Yan Yang
摘要： Techniques regarding polymers with antimicrobial functionality are provided. For example, one or more embodiments described herein can regard a polymer, which can comprise a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further, the repeating ionene unit can have antimicrobial functionality.
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公开(公告)号：US20210246309A1
公开(公告)日：2021-08-12
申请号：US17241768
申请日：2021-04-27
发明人： Nathaniel H. Park , James L. Hedrick , Victoria A. Piunova , Gavin Jones , Yi Yan Yang , Pang Kern Jeremy Tan , Chuan Yang , Cherylette Anne Alexander
IPC分类号： C08L79/02
摘要： Techniques regarding guanidinium functionalized polylysine polymers that can have antimicrobial and/or anticancer activity are provided. For example, one or more embodiments described herein can comprise a chemical composition, which can comprise a polymer comprising a molecular backbone covalently bonded to a pendent guanidinium functional group, wherein the molecular backbone can comprise a polylysine structure.
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公开(公告)号：US11045552B2
公开(公告)日：2021-06-29
申请号：US15479071
申请日：2017-04-04
申请人： International Business Machines Corporation , Agency for Science, Technology and Research (ASTAR)
发明人： Dylan J. Boday , Jeannette M. Garcia , James L. Hedrick , Nathaniel H. Park , Rudy J. Wojtecki , Yang Chuan , Ashlynn Lee , Zhen Chang Liang , Shaoqiong Liu , Yi Yan Yang
摘要： A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.
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公开(公告)号：US20210040319A1
公开(公告)日：2021-02-11
申请号：US16531432
申请日：2019-08-05
发明人： Nathaniel H. Park , James L. Hedrick , Victoria A. Piunova , Gavin Jones , Yi Yan Yang , Pang Kern Jeremy Tan , Chuan Yang , Cherylette Anne Alexander
IPC分类号： C08L79/02
摘要： Techniques regarding guanidinium functionalized polylysine polymers that can have antimicrobial and/or anticancer activity are provided. For example, one or more embodiments described herein can comprise a chemical composition, which can comprise a polymer comprising a molecular backbone covalently bonded to a pendent guanidinium functional group, wherein the molecular backbone can comprise a polylysine structure.
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公开(公告)号：US20210040265A1
公开(公告)日：2021-02-11
申请号：US17072771
申请日：2020-10-16
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Chuan Yang , Yi Yan Yang
IPC分类号： C08G73/02 , A61P31/06 , A61K31/787 , A61K31/166 , C07C13/47
摘要： Techniques regarding killing of a pathogen with one or more ionene compositions having antimicrobial functionality are provided. For example, one or more embodiments can comprise a method, which can comprise contacting a Mycobacterium tuberculosis microbe with a chemical compound. The chemical compound can comprise an ionene unit. Also, the ionene unit can comprise a cation distributed along a molecular backbone. The ionene unit can have antimicrobial functionality. The method can further comprise electrostatically disrupting a membrane of the Mycobacterium tuberculosis microbe in response to the contacting.
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公开(公告)号：US20200221695A1
公开(公告)日：2020-07-16
申请号：US16829370
申请日：2020-03-25
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Chuan Yang , Yi Yan Yang
摘要： Techniques regarding polymers with antimicrobial functionality are provided. For example, one or more embodiments described herein can regard a polymer, which can comprise a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further, the repeating ionene unit can have antimicrobial functionality.
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