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1.发明授权公开(公告)号：US11167036B2
公开(公告)日：2021-11-09
申请号：US16201155
申请日：2018-11-27
IPC分类号： A61K47/59 , A61K31/4188 , A61K31/155 , A61K47/55
摘要： The subject disclosure is directed to techniques for enhancing the selectivity and efficacy of therapeutic polymers against a broad spectrum of pathogens and cancer cell lines. According to an embodiment, a method is provided that comprises forming a therapeutic polymer based on polymerization of a plurality of therapeutic monomers, wherein the therapeutic polymer provides a therapeutic functionality. The method further comprises attaching biotin to the therapeutic polymer, resulting in a biotin-functionalized therapeutic polymer, wherein the biotin-functionalized therapeutic polymer provides greater therapeutic efficacy relative to the therapeutic polymer.
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公开(公告)号：US11006628B2
公开(公告)日：2021-05-18
申请号：US16744868
申请日：2020-01-16
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Yi Yan Yang
IPC分类号： A01N25/10 , A01N37/26 , A01N43/50 , A01N47/44 , C07C279/10 , C08L79/02 , C08G69/26 , C08G73/02 , C08L101/00 , A61Q17/00
摘要： Techniques regarding chemical compounds with antimicrobial functionality are provided. For example, one or more embodiments describe herein can comprise a monomer that can comprise a molecular backbone. The molecular backbone can comprise a bis(urea)guanidinium structure covalently bonded to a functional group, which can comprise a radical. Also, the monomer can have supramolecular assembly functionality.
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公开(公告)号：US10752787B2
公开(公告)日：2020-08-25
申请号：US16675754
申请日：2019-11-06
发明人： Amos Cahan , Xin Ding , Mareva B. Fevre , James L. Hedrick , Zhen Chang Liang , Nathaniel H. Park , Theodore G. van Kessel , Rudy J. Wojtecki , Yi Yan Yang
IPC分类号： C09D5/14 , C09D161/22 , A01N33/08 , A01N31/16 , C09D181/02 , A01N33/10 , B05D1/02 , B05D1/00 , B29C39/38 , B29C39/26 , A01N25/10 , C09D5/16 , G03F7/00 , B05D5/02
摘要： Embodiments are directed to a method of making an antifouling and bactericidal coating with tailorable surface topology. The method includes depositing a layer of branched polyethyleneimine (BPEI) and diamino-functionalized poly(propylene oxide) (PPO) in a mixture of water and organic solvent on a substrate to form a layer of BPEI/PPO. The method includes depositing a layer of glyoxal in a water-containing solution on the layer of BPEI/PPO. The method further includes curing the layer of BPEI/PPO and layer of glyoxal to form a homogenous, glyoxal crosslinked BPEI/PPO coating, where the curing induces local precipitation and alteration of the glyoxal crosslinked BPEI/PPO coating to provide a textured surface.
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公开(公告)号：US20200221692A1
公开(公告)日：2020-07-16
申请号：US16744868
申请日：2020-01-16
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Yi Yan Yang
IPC分类号： A01N25/10 , A01N43/50 , A01N37/26 , C07C279/10 , C08L79/02 , C08G69/26 , C08G73/02 , A01N47/44 , C08L101/00
摘要： Techniques regarding chemical compounds with antimicrobial functionality are provided. For example, one or more embodiments describe herein can comprise a monomer that can comprise a molecular backbone. The molecular backbone can comprise a bis(urea)guanidinium structure covalently bonded to a functional group, which can comprise a radical. Also, the monomer can have supramolecular assembly functionality.
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公开(公告)号：US10687530B2
公开(公告)日：2020-06-23
申请号：US15839388
申请日：2017-12-12
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Yi Yan Yang , Mu San Zhang
IPC分类号： A01N37/18 , C08G69/40 , A01N33/12 , A01N43/50 , C08L101/00
摘要： Techniques regarding ionene and/or polyionene compositions with antimicrobial functionality and enhanced hydrophilicity are provided. For example, one or more embodiments can regard a chemical compound that can comprise an ionene unit, which can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. The ionene unit can have antimicrobial functionality. Further, the chemical compound can comprise a hydrophilic functional group covalently bonded to the ionene unit. Also, the chemical compound can have carbohydrate mimetic functionality.
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公开(公告)号：US10507267B2
公开(公告)日：2019-12-17
申请号：US15496473
申请日：2017-04-25
发明人： Amos Cahan , Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Theodore G. van Kessel , Rudy J. Wojtecki , Yi Yan Yang
IPC分类号： C09D183/04 , A61L31/10 , A61L29/08 , A61L29/16 , A61L31/16 , A61L27/34 , A61L27/54 , A61L27/50 , C08G75/20 , C09D181/06 , C08G75/0227 , C08G75/0213 , C09D181/02 , B05D5/00 , B05D1/00 , B05D3/02
摘要： Antibacterial coatings and methods of making the antibacterial coatings are described herein. In particular, a method for forming an organocatalyzed polythioether coating is provided in which a first solution including a bis-silylated dithiol and a fluoroarene is prepared. A second solution including an organocatalyst is prepared. The first solution and the second solution are mixed to form a mixed solution. The mixed solution is applied to a substrate, and the substrate is cured.
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公开(公告)号：US20190177479A1
公开(公告)日：2019-06-13
申请号：US15839410
申请日：2017-12-12
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Chuan Yang , Yi Yan Yang
IPC分类号： C08G73/02 , C07C13/47 , A61K31/787 , A61K31/166 , A61P31/06
摘要： Techniques regarding killing of a pathogen with one or more ionene compositions having antimicrobial functionality are provided. For example, one or more embodiments can comprise a method, which can comprise contacting a mycobacterium tuberculosis microbe with a chemical compound. The chemical compound can comprise an ionene unit. Also, the ionene unit can comprise a cation distributed along a molecular backbone. The ionene unit can have antimicrobial functionality. The method can further comprise electrostatically disrupting a membrane of the mycobacterium tuberculosis microbe in response to the contacting.
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公开(公告)号：US20190174753A1
公开(公告)日：2019-06-13
申请号：US15839397
申请日：2017-12-12
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Chaun Yang , Yi Yan Yang
摘要： Techniques regarding ionene and/or polyionene compositions with antimicrobial functionalities are provided. For example, one or more embodiments can comprise a chemical compound, which can comprise an ionene unit. The ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a norspermidine structure having a carbonyl group. Also, the ionene unit can have antimicrobial functionality.
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公开(公告)号：US20230331988A1
公开(公告)日：2023-10-19
申请号：US18333173
申请日：2023-06-12
发明人： Nathaniel H. Park , James L. Hedrick , Victoria A. Piunova , Gavin Jones , Yi Yan Yang , Pang Kern Jeremy Tan , Chuan Yang , Cherylette Anne Alexander
IPC分类号： C08L79/02
摘要： Techniques regarding guanidinium functionalized polylysine polymers that can have antimicrobial and/or anticancer activity are provided. For example, one or more embodiments described herein can comprise a chemical composition, which can comprise a polymer comprising a molecular backbone covalently bonded to a pendent guanidinium functional group, wherein the molecular backbone can comprise a polylysine structure.
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公开(公告)号：US20220265702A1
公开(公告)日：2022-08-25
申请号：US17659183
申请日：2022-04-14
发明人： James L. Hedrick , Yi Yan Yang , Nathaniel H. Park , Jiayu Leong , Chuan Yang , Xin Ding , Yiran Zhen , Cherylette Anne Alexander , Jye Yng Teo
IPC分类号： A61K31/785
摘要： Techniques regarding a chemical composition that can be utilized within one or more combination therapies to treat a microbial infection are provided. For example, one or more embodiments described herein can comprise a chemical composition that includes a first triblock polymer comprising a quaternary ammonium functionalized polycarbonate block and exhibiting anticancer activity via a lytic mechanism. The chemical composition can also include a second triblock polymer comprising a guanidinium functionalized polycarbonate block and exhibiting anticancer activity via a translocation mechanism.
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