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1.发明申请Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer 审中-公开用于鉴别，评估，预防和治疗乳腺癌的组合物，试剂盒和方法公开(公告)号：US20080311573A1
公开(公告)日：2008-12-18
申请号：US11821773
申请日：2007-06-25
申请人： James Lillie , Manjula Gannavarapu , Karen Glatt , Sebastian Hoersch , Shubhangi Kamatkar , Maureen Mertens , John E. Monahan , Vickesh Myer , Youzhen Wang , Yongyao Xu , Xumei Zhao , Rachel E. Meyers , Robert C. Bast, JR. , Gabriel N. Hortobagyi , Lajos Pusztai , Funda Meric , Aysegul Sahin , Gordon B. Mills
发明人： James Lillie , Manjula Gannavarapu , Karen Glatt , Sebastian Hoersch , Shubhangi Kamatkar , Maureen Mertens , John E. Monahan , Vickesh Myer , Youzhen Wang , Yongyao Xu , Xumei Zhao , Rachel E. Meyers , Robert C. Bast, JR. , Gabriel N. Hortobagyi , Lajos Pusztai , Funda Meric , Aysegul Sahin , Gordon B. Mills
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.
摘要翻译： 本发明涉及新发现的与乳腺癌相关的核酸分子和蛋白质。 提供了用于检测，表征，预防和治疗人乳腺癌的组合物，试剂盒和方法。
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2.发明授权Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer 失效用于鉴别，评估，预防和治疗乳腺癌的组合物，试剂盒和方法公开(公告)号：US07705120B2
公开(公告)日：2010-04-27
申请号：US10177293
申请日：2002-06-21
申请人： James Lillie , Manjula Gannavarapu , Karen Glatt , Sebastian Hoersch , Shubhangi Kamatkar , Maureen Mertens, Hattersley , John E. Monahan , Vickesh Myer , Youzhen Wang , Yongyao Xu , Xumei Zhao , Rachel E. Meyers , Robert C. Bast, Jr. , Gabriel N. Hortobagyi , Lajos Pusztai
发明人： James Lillie , Manjula Gannavarapu , Karen Glatt , Sebastian Hoersch , Shubhangi Kamatkar , Maureen Mertens, Hattersley , John E. Monahan , Vickesh Myer , Youzhen Wang , Yongyao Xu , Xumei Zhao , Rachel E. Meyers , Robert C. Bast, Jr. , Gabriel N. Hortobagyi , Lajos Pusztai
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.
摘要翻译： 本发明涉及新发现的与乳腺癌相关的核酸分子和蛋白质。 提供了用于检测，表征，预防和治疗人乳腺癌的组合物，试剂盒和方法。
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3.发明申请COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF BREAST CANCER 审中-公开乳腺癌的鉴定，评估，预防和治疗的组合物，试剂盒和方法公开(公告)号：US20110092388A1
公开(公告)日：2011-04-21
申请号：US12953099
申请日：2010-11-23
申请人： JAMES LILLIE , Manjula Gannavarapu , Karen Glatt , Sebastian Hoersch , Shubhangi Kamatkar , Maureen Mertens Hattersley , John E. Monahan , Vickesh Myer , Youzhen Wang , Yong Yao Xu , Xumei Zhao , Rachel E. Meyers , Robert C. Bast, JR. , Gabriel N. Hortobagyi , Lajos Pusztai
发明人： JAMES LILLIE , Manjula Gannavarapu , Karen Glatt , Sebastian Hoersch , Shubhangi Kamatkar , Maureen Mertens Hattersley , John E. Monahan , Vickesh Myer , Youzhen Wang , Yong Yao Xu , Xumei Zhao , Rachel E. Meyers , Robert C. Bast, JR. , Gabriel N. Hortobagyi , Lajos Pusztai
IPC分类号： C40B30/04 , G01N33/53 , C12Q1/68 , C07H21/00 , C12N15/63 , C12N5/10 , C07K14/47 , C12N9/88 , C12N9/02 , C12N9/90 , C07K16/18 , C07K16/40 , G01N33/566
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.
摘要翻译： 本发明涉及新发现的与乳腺癌相关的核酸分子和蛋白质。 提供了用于检测，表征，预防和治疗人乳腺癌的组合物，试剂盒和方法。
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公开(公告)号：US20090005411A1
公开(公告)日：2009-01-01
申请号：US12158130
申请日：2006-12-18
IPC分类号： A61K31/437 , A61P35/00
CPC分类号： A61K31/437 , A61K31/16 , A61K31/337 , A61K31/425 , A61K31/475 , A61K45/06 , C07D471/04 , A61K2300/00
摘要： The invention provides a pharmaceutical combination comprising: a) compounds that inhibit the binding of the Smac protein to IAPs; and b) a taxane, and a method for treating or preventing a proliferative disease using such a combination.
摘要翻译： 本发明提供药物组合，其包含：a）抑制Smac蛋白与IAP结合的化合物; 和b）紫杉烷类，以及使用这种组合治疗或预防增殖性疾病的方法。
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公开(公告)号：US20140314784A1
公开(公告)日：2014-10-23
申请号：US14232751
申请日：2012-07-19
申请人： Vahe Bedian , Youzhen Wang , Ian Foltz , Palaniswami Rathanaswami , Jaspal Singh Kang , Adeela Kamal , Philipp Steiner
发明人： Vahe Bedian , Youzhen Wang , Ian Foltz , Palaniswami Rathanaswami , Jaspal Singh Kang , Adeela Kamal , Philipp Steiner
IPC分类号： C07K16/28 , A61K45/06 , A61K39/395
CPC分类号： C07K16/2866 , A61K39/3955 , A61K45/06 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The disclosure relates to antibodies or antigen binding fragments that specifically bind to CXCR4 and inhibit the biological activity of CXCR4 and uses of such agents. More specifically the disclosure relates to fully human antibodies or antigen binding fragments directed to CXCR4 that specifically bind to CXCR4 and uses of these antibodies. Aspects of the disclosure also relate to hybridomas or other cell lines expressing such antibodies. The disclosed antibodies (including antigen binding fragments) are useful as diagnostics and for the treatment of diseases associated with the activity and/or expression of CXCR4.
摘要翻译： 本公开涉及特异性结合CXCR4并抑制CXCR4的生物学活性的抗体或抗原结合片段以及这些试剂的用途。 更具体地，本公开涉及针对CXCR4的完全人抗体或抗原结合片段，其特异性结合CXCR4和这些抗体的用途。 本公开的方面还涉及表达这种抗体的杂交瘤或其它细胞系。 所公开的抗体（包括抗原结合片段）可用作诊断和治疗与CXCR4的活性和/或表达相关的疾病。
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6.发明申请COMBINATION OF AN IAP INHIBITOR AND A TAXANE FOR THE TREATMENT OF A PROLIFERATIVE DISEASE 审中-公开IAP抑制剂和TAXANE治疗增殖性疾病的联合公开(公告)号：US20130085153A1
公开(公告)日：2013-04-04
申请号：US13547546
申请日：2012-07-12
IPC分类号： A61K31/437 , A61K31/337
CPC分类号： A61K31/437 , A61K31/16 , A61K31/337 , A61K31/425 , A61K31/475 , A61K45/06 , C07D471/04 , A61K2300/00
摘要： The invention provides a pharmaceutical combination comprising: a) compounds that inhibit the binding of the Smac protein to IAPs; and b) a taxane, and a method for treating or preventing a proliferative disease using such a combination.
摘要翻译： 本发明提供药物组合，其包含：a）抑制Smac蛋白与IAP结合的化合物; 和b）紫杉烷类，以及使用这种组合治疗或预防增殖性疾病的方法。
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