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1.发明申请Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer 审中-公开用于鉴别，评估，预防和治疗乳腺癌的组合物，试剂盒和方法公开(公告)号：US20080311573A1
公开(公告)日：2008-12-18
申请号：US11821773
申请日：2007-06-25
申请人： James Lillie , Manjula Gannavarapu , Karen Glatt , Sebastian Hoersch , Shubhangi Kamatkar , Maureen Mertens , John E. Monahan , Vickesh Myer , Youzhen Wang , Yongyao Xu , Xumei Zhao , Rachel E. Meyers , Robert C. Bast, JR. , Gabriel N. Hortobagyi , Lajos Pusztai , Funda Meric , Aysegul Sahin , Gordon B. Mills
发明人： James Lillie , Manjula Gannavarapu , Karen Glatt , Sebastian Hoersch , Shubhangi Kamatkar , Maureen Mertens , John E. Monahan , Vickesh Myer , Youzhen Wang , Yongyao Xu , Xumei Zhao , Rachel E. Meyers , Robert C. Bast, JR. , Gabriel N. Hortobagyi , Lajos Pusztai , Funda Meric , Aysegul Sahin , Gordon B. Mills
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.
摘要翻译： 本发明涉及新发现的与乳腺癌相关的核酸分子和蛋白质。 提供了用于检测，表征，预防和治疗人乳腺癌的组合物，试剂盒和方法。
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2.发明授权Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer 失效用于鉴别，评估，预防和治疗乳腺癌的组合物，试剂盒和方法公开(公告)号：US07705120B2
公开(公告)日：2010-04-27
申请号：US10177293
申请日：2002-06-21
申请人： James Lillie , Manjula Gannavarapu , Karen Glatt , Sebastian Hoersch , Shubhangi Kamatkar , Maureen Mertens, Hattersley , John E. Monahan , Vickesh Myer , Youzhen Wang , Yongyao Xu , Xumei Zhao , Rachel E. Meyers , Robert C. Bast, Jr. , Gabriel N. Hortobagyi , Lajos Pusztai
发明人： James Lillie , Manjula Gannavarapu , Karen Glatt , Sebastian Hoersch , Shubhangi Kamatkar , Maureen Mertens, Hattersley , John E. Monahan , Vickesh Myer , Youzhen Wang , Yongyao Xu , Xumei Zhao , Rachel E. Meyers , Robert C. Bast, Jr. , Gabriel N. Hortobagyi , Lajos Pusztai
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.
摘要翻译： 本发明涉及新发现的与乳腺癌相关的核酸分子和蛋白质。 提供了用于检测，表征，预防和治疗人乳腺癌的组合物，试剂盒和方法。
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3.发明申请COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF BREAST CANCER 审中-公开乳腺癌的鉴定，评估，预防和治疗的组合物，试剂盒和方法公开(公告)号：US20110092388A1
公开(公告)日：2011-04-21
申请号：US12953099
申请日：2010-11-23
申请人： JAMES LILLIE , Manjula Gannavarapu , Karen Glatt , Sebastian Hoersch , Shubhangi Kamatkar , Maureen Mertens Hattersley , John E. Monahan , Vickesh Myer , Youzhen Wang , Yong Yao Xu , Xumei Zhao , Rachel E. Meyers , Robert C. Bast, JR. , Gabriel N. Hortobagyi , Lajos Pusztai
发明人： JAMES LILLIE , Manjula Gannavarapu , Karen Glatt , Sebastian Hoersch , Shubhangi Kamatkar , Maureen Mertens Hattersley , John E. Monahan , Vickesh Myer , Youzhen Wang , Yong Yao Xu , Xumei Zhao , Rachel E. Meyers , Robert C. Bast, JR. , Gabriel N. Hortobagyi , Lajos Pusztai
IPC分类号： C40B30/04 , G01N33/53 , C12Q1/68 , C07H21/00 , C12N15/63 , C12N5/10 , C07K14/47 , C12N9/88 , C12N9/02 , C12N9/90 , C07K16/18 , C07K16/40 , G01N33/566
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.
摘要翻译： 本发明涉及新发现的与乳腺癌相关的核酸分子和蛋白质。 提供了用于检测，表征，预防和治疗人乳腺癌的组合物，试剂盒和方法。
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4.发明授权Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer 失效用于鉴别，评估，预防和治疗乳腺癌的组合物，试剂盒和方法公开(公告)号：US07601505B2
公开(公告)日：2009-10-13
申请号：US10855588
申请日：2004-05-26
申请人： John E. Monahan , Sebastian Hoersch , Dustin L. Anderson , Wilson O. Endege , Donna Ford , Karen Glatt , Bella O. Gorbatcheva , Shubhangi Kamatkar , Yong Yao Xu , Manjula Gannavarapu , Xumei Zhao , Robert Schlegel , Maureen Mertens , Robert C. Bast, Jr. , Gabriel N. Hortobagyi , Lajos Pusztai
发明人： John E. Monahan , Sebastian Hoersch , Dustin L. Anderson , Wilson O. Endege , Donna Ford , Karen Glatt , Bella O. Gorbatcheva , Shubhangi Kamatkar , Yong Yao Xu , Manjula Gannavarapu , Xumei Zhao , Robert Schlegel , Maureen Mertens , Robert C. Bast, Jr. , Gabriel N. Hortobagyi , Lajos Pusztai
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/57415
摘要： The invention relates to nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.
摘要翻译： 本发明涉及与乳腺癌相关的核酸分子和蛋白质。 提供了用于检测，表征，预防和治疗人乳腺癌的组合物，试剂盒和方法。
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5.发明申请COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF BREAST CANCER 审中-公开乳腺癌的鉴定，评估，预防和治疗的组合物，试剂盒和方法公开(公告)号：US20100075325A1
公开(公告)日：2010-03-25
申请号：US12557795
申请日：2009-09-11
申请人： John E. Monahan , Sebastian Hoersch , Dustin L. Anderson , Wilson O. Endege , Donna Ford , Karen Glatt , Bella O. Gorbatcheva , Shubhangi Kamatkar , Yong Yao Xu , Manjula Gannavarapu , Xumei Zhao , Robert Schlegel , Maureen Mertens Hattersley , Robert C. Bast, JR. , Gabriel N. Hortobagyi , Lajos Pusztai
发明人： John E. Monahan , Sebastian Hoersch , Dustin L. Anderson , Wilson O. Endege , Donna Ford , Karen Glatt , Bella O. Gorbatcheva , Shubhangi Kamatkar , Yong Yao Xu , Manjula Gannavarapu , Xumei Zhao , Robert Schlegel , Maureen Mertens Hattersley , Robert C. Bast, JR. , Gabriel N. Hortobagyi , Lajos Pusztai
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/57415
摘要： The invention relates to nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.
摘要翻译： 本发明涉及与乳腺癌相关的核酸分子和蛋白质。 提供了用于检测，表征，预防和治疗人乳腺癌的组合物，试剂盒和方法。
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6.发明申请Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer 审中-公开用于鉴别，评估，预防和治疗乳腺癌的组合物，试剂盒和方法公开(公告)号：US20100009358A1
公开(公告)日：2010-01-14
申请号：US12317078
申请日：2008-12-18
申请人： Mark D. Ayers , Jim Stec , Andrew Damokosh , Edwin Clark , Kenneth R. Hess , Gabriel N. Hortobagyi , Lajos Pusztai , W. Fraser Symmans , Robert C. Bast, JR.
发明人： Mark D. Ayers , Jim Stec , Andrew Damokosh , Edwin Clark , Kenneth R. Hess , Gabriel N. Hortobagyi , Lajos Pusztai , W. Fraser Symmans , Robert C. Bast, JR.
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158
摘要： The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers. A variety of newly identified markers are provided, wherein changes in the levels of expression of one or more of the markers is correlated with the presence of breast cancer.
摘要翻译： 本发明涉及用于检测，表征，预防和治疗人乳腺癌的组合物，试剂盒和方法。 提供了多种新鉴定的标记物，其中一种或多种标记物的表达水平的变化与乳腺癌的存在相关。
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7.发明授权Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer 失效用于鉴别，评估，预防和治疗乳腺癌的组合物，试剂盒和方法公开(公告)号：US07504222B2
公开(公告)日：2009-03-17
申请号：US10285393
申请日：2002-10-31
申请人： Mark D. Ayers , Jim Stec , Andrew Damokosh , Edwin Clark , Kenneth R. Hess , Gabriel N. Hortobagyi , Lajos Pusztai , W. Fraser Symmans , Robert C. Bast, Jr.
发明人： Mark D. Ayers , Jim Stec , Andrew Damokosh , Edwin Clark , Kenneth R. Hess , Gabriel N. Hortobagyi , Lajos Pusztai , W. Fraser Symmans , Robert C. Bast, Jr.
IPC分类号： G01N33/53
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158
摘要： The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers. A variety of newly identified markers are provided, wherein changes in the levels of expression of one or more of the markers is correlated with the presence of breast cancer.
摘要翻译： 本发明涉及用于检测，表征，预防和治疗人乳腺癌的组合物，试剂盒和方法。 提供了多种新鉴定的标记物，其中一种或多种标记物的表达水平的变化与乳腺癌的存在相关。
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8.发明申请INDEX OF GENOMIC EXPRESSION OF ESTROGEN RECEPTOR (ER) AND ER-RELATED GENES 审中-公开雌激素受体（ER）和ER相关基因的基因表达指数公开(公告)号：US20100311601A1
公开(公告)日：2010-12-09
申请号：US12772816
申请日：2010-05-03
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , G16B25/00
摘要： The present invention provides the identification and combination of genes that are expressed in tumors that are responsive to a given therapeutic agent and whose combined expression can be used as an index that correlates with responsiveness to that therapeutic agent. One or more of the genes of the present invention may be used as markers (or surrogate markers) to identify tumors that are likely to be successfully treated by that agent or class of agents such as hormonal or endocrine therapy or chemotherapy.
摘要翻译： 本发明提供了在对给定治疗剂有反应的肿瘤中表达的基因的鉴定和组合，并且其组合表达可用作与对该治疗剂的反应性相关的指标。 本发明的一个或多个基因可用作标志物（或替代标记物），以鉴定可能由该试剂或类别的试剂例如激素或内分泌治疗或化学疗法成功治疗的肿瘤。
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9.发明申请CALCULATED INDEX OF GENOMIC EXPRESSION OF ESTROGEN RECEPTOR (ER) AND ER-RELATED GENES 审中-公开雌激素受体（ER）和ER相关基因的基因表达的计算指数公开(公告)号：US20070134688A1
公开(公告)日：2007-06-14
申请号：US11530785
申请日：2006-09-11
IPC分类号： C12Q1/68 , G01N33/574 , A61K31/56
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N33/6842 , G01N33/743 , G01N2333/723 , G01N2800/52 , G16B20/00 , G16B25/00
摘要： The present invention provides the identification and combination of genes that are expressed in tumors that are responsive to a given therapeutic agent and whose combined expression can be used as an index that correlates with responsiveness to that therapeutic agent. One or more of the genes of the present invention may be used as markers (or surrogate markers) to identify tumors that are likely to be successfully treated by that agent or class of agents such as hormonal or endocrine treatment.
摘要翻译： 本发明提供了在对给定治疗剂有反应的肿瘤中表达的基因的鉴定和组合，并且其组合表达可用作与对该治疗剂的反应性相关的指标。 本发明的一个或多个基因可以用作标记物（或替代标记物），以鉴定可能被该试剂或一类试剂例如激素或内分泌治疗成功治疗的肿瘤。
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10.发明申请公开(公告)号：US20100178651A1
公开(公告)日：2010-07-15
申请号：US12513338
申请日：2007-11-05
申请人： Christos Hatzis , Fraser W Symmans , Lajos Pusztai
发明人： Christos Hatzis , Fraser W Symmans , Lajos Pusztai
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136
摘要： The present invention provides the identification of genes that are expressed in tumors to indicate responsiveness or resistance to an agent or class of agents. More particularly, these genes show expression associated with responsiveness to one agent or class of agents is inversely related to expression in association with another class of agents. One or more of theses genes of the present invention can be used as markers (or surrogate markers) to identify tumors that are likely to be successfully treated by the responsive agent as well as to identify tumors that should avoid treatment by the resistant agent.
摘要翻译： 本发明提供了在肿瘤中表达的基因的鉴定，以指示对试剂或试剂类的反应性或抗性。 更具体地说，这些基因表现出与一种药剂的反应性相关的表达或与另一类药剂相关的表达是负相关的。 本发明的一个或多个这些基因可以用作标记物（或替代标记物）来鉴定可能被响应剂成功治疗的肿瘤以及鉴定应该避免被抗药剂治疗的肿瘤。
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