公开(公告)号：US20230002409A1

公开(公告)日：2023-01-05

申请号：US17694757

申请日：2022-03-15

申请人： Janssen BioPharma, Inc.

发明人： Robert Than HENDRICKS ,  Antitsa Dimitrova STOYCHEVA ,  Jean-François BONFANTI ,  Pierre Jean-Marie Bernard RABOISSON ,  Jérôme Michel Claude FORTIN ,  Guillaume Jean Maurice MERCEY

IPC分类号： C07D498/22 ,  A61P31/16 ,  C07D471/18 ,  C07D471/22 ,  C07D495/22 ,  C07D498/18

摘要： The present invention relates to macrocyclic pyridotriazine derivatives and the prodrugs thereof, and the pharmaceutically acceptable salts, solvates or polymorph thereof, and the use of such compounds as a medicament, in particular in the prevention and/or treatment of viral infections caused by viruses belonging to the Orthomyxoviridae family. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, and to the compositions or preparations for use as a medicament, more preferably for the prevention or treatment of viral infections caused by viruses belonging to the Orthomyxoviridae family.

公开(公告)号：US20210186969A1

公开(公告)日：2021-06-24

申请号：US17185750

申请日：2021-02-25

申请人： Janssen BioPharma, Inc.

发明人： Robert Than HENDRICKS ,  Leonid BEIGELMAN ,  David Bernard SMITH ,  Antitsa Dimitrova STOYCHEVA

IPC分类号： A61K31/5025 ,  C07D487/04 ,  A61K31/13 ,  A61K31/196 ,  A61K31/215 ,  A61K31/351 ,  A61K31/4965 ,  A61K31/5377 ,  A61K31/7056 ,  A61K38/21 ,  C07B59/00

摘要： Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection, with an aza-pyridone compounds. Examples of an orthomyxovirus viral infection include an influenza infection.

公开(公告)号：US20210040483A1

公开(公告)日：2021-02-11

申请号：US17063080

申请日：2020-10-05

申请人： Janssen Biopharma, Inc.

发明人： Sergei GRYAZNOV ,  Leonid BEIGELMAN ,  Antitsa Dimitrova STOYCHEVA ,  Saul MARTINEZ MONTERO ,  Jin HONG ,  Rajendra K. PANDEY ,  Vivek Kumar RAJWANSHI ,  Lakshmipathi PANDARINATHAN ,  Yi JIN ,  Bharat BARAL

IPC分类号： C12N15/113 ,  A61K31/7125 ,  A61P31/20 ,  A61K31/712 ,  C07H21/02 ,  A61K47/54 ,  C12N15/11

摘要： Modified oligonucleotides comprising modifications at the 2′ and/or 3′ position(s) along with methods of making and use, e.g., against HBV are disclosed.