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    Structurally modified peptides that are resistant to peptidase degradation
    2.
    发明授权
    Structurally modified peptides that are resistant to peptidase degradation 失效
    对肽酶降解有抗性的结构修饰的肽

    公开(公告)号：US06623740B1

    公开(公告)日：2003-09-23

    申请号：US09114002

    申请日：1998-07-10

    申请人： Jean Edouard Gairin ,  Maha Ayyoub ,  Benoit Van Den Eynde ,  Honoré Mazarguil ,  Bernard Monsarrat

    发明人： Jean Edouard Gairin ,  Maha Ayyoub ,  Benoit Van Den Eynde ,  Honoré Mazarguil ,  Bernard Monsarrat

    IPC分类号： A61K3800

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K39/00 ,  Y10S514/885

    摘要： Human melanoma cells bear antigens that are recognized by autologous CD8+ cytotoxic T-lymphocytes. The invention involves the reception of particular peptides analogues of the MZ2-E antigen by HLA molecules. Disclosed herein are peptide analogues of the tumor antigen MZ2-E that have been modified to resist peptidase degradation, and which bind HLA molecules to form a complex whose recognition by specific cytolytic T cells leads to lysis of the complex. The identification by cytolytic T cells of the peptide analogue/HLA complex may be used in diagnostics, or therapeutically.

    摘要翻译： 人黑素瘤细胞承载由自体CD8 +细胞毒性T淋巴细胞识别的抗原。 本发明涉及通过HLA分子接收MZ2-E抗原的特定肽类似物。 本文公开了经修饰以抵抗肽酶降解的肿瘤抗原MZ2-E的肽类似物，并且其结合HLA分子以形成其特异性溶细胞T细胞的识别导致复合物裂解的复合物。 肽类似物/ HLA复合物的溶细胞T细胞的鉴定可用于诊断或治疗。

    SSX-2 peptides presented by HLA class II molecules
    3.
    发明授权
    SSX-2 peptides presented by HLA class II molecules 有权
    由HLA II类分子呈递的SSX-2肽

    公开(公告)号：US09200047B2

    公开(公告)日：2015-12-01

    申请号：US13028953

    申请日：2011-02-16

    申请人： Danila Valmori ,  Maha Ayyoub

    发明人： Danila Valmori ,  Maha Ayyoub

    IPC分类号： A61K38/00 ,  C07K14/47

    CPC分类号： C07K14/4748 ,  A61K38/00

    摘要： The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-2 gene.

    摘要翻译： 本发明描述了由SSX-2肿瘤相关基因编码的HLA II类结合肽，以及编码与其有关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以SSX-2基因表达为特征的病症的方法和产品。

    Ssx-2 peptides presented by hla class II molecules
    4.
    发明申请
    Ssx-2 peptides presented by hla class II molecules 有权
    由hla II类分子呈递的Ssx-2肽

    公开(公告)号：US20060189001A1

    公开(公告)日：2006-08-24

    申请号：US10565315

    申请日：2004-07-21

    申请人： Danila Valmori ,  Maha Ayyoub

    发明人： Danila Valmori ,  Maha Ayyoub

    IPC分类号： C07H21/04 ,  C12P21/06 ,  G01N33/543 ,  C07K14/74

    CPC分类号： C07K14/4748 ,  A61K38/00

    摘要： The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-2 gene.

    摘要翻译： 本发明描述了由SSX-2肿瘤相关基因编码的HLA II类结合肽，以及编码与其有关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以SSX-2基因表达为特征的病症的方法和产品。

    SSX-4 peptides presented by HLA class II molecules
    5.
    发明申请
    SSX-4 peptides presented by HLA class II molecules 有权
    由HLA II类分子呈递的SSX-4肽

    公开(公告)号：US20060051772A1

    公开(公告)日：2006-03-09

    申请号：US10936888

    申请日：2004-09-09

    申请人： Danila Valmori ,  Maha Ayyoub

    发明人： Danila Valmori ,  Maha Ayyoub

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/74

    CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07K16/2833 ,  C07K16/30 ,  C12Q1/6886 ,  C12Q2600/158

    摘要： The invention describes HLA class II binding peptides encoded by the SSX-4 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-4 gene.

    摘要翻译： 本发明描述了由SSX-4肿瘤相关基因编码的HLA II类结合肽，以及编码与其相关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以SSX-4基因表达为特征的病症的方法和产品。

    SSX-2 peptides presented by HLA class II molecules
    6.
    发明申请
    SSX-2 peptides presented by HLA class II molecules 失效
    由HLA II类分子呈递的SSX-2肽

    公开(公告)号：US20050079553A1

    公开(公告)日：2005-04-14

    申请号：US10937794

    申请日：2004-09-09

    申请人： Maha Ayyoub ,  Danila Valmori

    发明人： Maha Ayyoub ,  Danila Valmori

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C12Q1/68 ,  C07K14/74 ,  C07K16/28 ,  G01N33/53 ,  G01N33/567

    CPC分类号： C07K14/4748 ,  A61K38/00

    摘要： The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-2 gene.

    摘要翻译： 本发明描述了由SSX-2肿瘤相关基因编码的HLA II类结合肽，以及编码与其有关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以SSX-2基因表达为特征的病症的方法和产品。

    SSX-2 PEPTIDES PRESENTED BY HLA CLASS II MOLECULES
    7.
    发明申请
    SSX-2 PEPTIDES PRESENTED BY HLA CLASS II MOLECULES 有权
    SSX-2由HLA II类分子表达的肽

    公开(公告)号：US20110144186A1

    公开(公告)日：2011-06-16

    申请号：US13028953

    申请日：2011-02-16

    申请人： Danila Valmori ,  Maha Ayyoub

    发明人： Danila Valmori ,  Maha Ayyoub

    IPC分类号： A61K31/7088 ,  C07H21/00 ,  A61P35/00

    CPC分类号： C07K14/4748 ,  A61K38/00

    摘要： The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-2 gene.

    摘要翻译： 本发明描述了由SSX-2肿瘤相关基因编码的HLA II类结合肽，以及编码与其有关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以SSX-2基因表达为特征的病症的方法和产品。

    Ssx-2 peptides presented by hla class II molecules
    8.
    发明授权
    Ssx-2 peptides presented by hla class II molecules 有权
    由hla II类分子呈递的Ssx-2肽

    公开(公告)号：US07910696B2

    公开(公告)日：2011-03-22

    申请号：US10565315

    申请日：2004-07-21

    申请人： Danila Valmori ,  Maha Ayyoub

    发明人： Danila Valmori ,  Maha Ayyoub

    IPC分类号： C12P21/06

    CPC分类号： C07K14/4748 ,  A61K38/00

    摘要： The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-2 gene.

    摘要翻译： 本发明描述了由SSX-2肿瘤相关基因编码的HLA II类结合肽，以及编码与其有关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以SSX-2基因表达为特征的病症的方法和产品。

    SSX-4 peptides presented by HLA class II molecules
    9.
    发明授权
    SSX-4 peptides presented by HLA class II molecules 有权
    由HLA II类分子呈递的SSX-4肽

    公开(公告)号：US07858743B2

    公开(公告)日：2010-12-28

    申请号：US10936888

    申请日：2004-09-09

    申请人： Danila Valmori ,  Maha Ayyoub

    发明人： Danila Valmori ,  Maha Ayyoub

    IPC分类号： C07K7/00

    CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07K16/2833 ,  C07K16/30 ,  C12Q1/6886 ,  C12Q2600/158

    摘要： The invention describes HLA class II binding peptides encoded by the SSX-4 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-4 gene.

    摘要翻译： 本发明描述了由SSX-4肿瘤相关基因编码的HLA II类结合肽，以及编码与其有关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以SSX-4基因表达为特征的病症的方法和产品。

    SSX-2 PEPTIDES PRESENTED BY HLA CLASS II MOLECULES
    10.
    发明申请
    SSX-2 PEPTIDES PRESENTED BY HLA CLASS II MOLECULES 有权
    SSX-2由HLA II类分子表达的肽

    公开(公告)号：US20090099063A1

    公开(公告)日：2009-04-16

    申请号：US12233964

    申请日：2008-09-19

    申请人： Maha Ayyoub ,  Danila Valmori

    发明人： Maha Ayyoub ,  Danila Valmori

    IPC分类号： A61K38/02

    CPC分类号： C07K14/4748 ,  A61K38/00

    摘要： The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating to the peptides. The peptides stimulate the activity and proliferation of CD4+T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-2 gene.

    摘要翻译： 本发明描述了由SSX-2肿瘤相关基因编码的HLA II类结合肽，以及编码与肽有关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以SSX-2基因表达为特征的病症的方法和产品。