公开(公告)号：US20050272666A1

公开(公告)日：2005-12-08

申请号：US11001610

申请日：2004-12-02

申请人： Jing Wu ,  Jay Tung ,  Eugene Thorsett ,  Michael Pleiss ,  Jeffrey Nissen ,  Jeffrey Neitz ,  Lee Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas Britton ,  James Audia ,  Jon Reel ,  Thomas Mabry ,  Bruce Dressman ,  Cynthia Cwi ,  James Droste ,  Steven Henry ,  Stacey McDaniel ,  William Scott ,  Russell Stucky ,  Warren Porter

发明人： Jing Wu ,  Jay Tung ,  Eugene Thorsett ,  Michael Pleiss ,  Jeffrey Nissen ,  Jeffrey Neitz ,  Lee Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas Britton ,  James Audia ,  Jon Reel ,  Thomas Mabry ,  Bruce Dressman ,  Cynthia Cwi ,  James Droste ,  Steven Henry ,  Stacey McDaniel ,  William Scott ,  Russell Stucky ,  Warren Porter

IPC分类号： A61K31/40 ,  A61K31/4015 ,  A61K31/445 ,  A61K31/55 ,  A61K38/04 ,  A61K38/05 ,  A61P25/28 ,  C07D223/18 ,  C07D471/04 ,  C07D471/06 ,  C07D471/08

CPC分类号： C07D471/04 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/445 ,  A61K31/5513 ,  A61K38/05 ,  C07C237/22 ,  C07C2603/32 ,  C07D223/18 ,  C07D307/33 ,  C07D311/76 ,  C07D471/06 ,  C07D471/08

摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

公开(公告)号：US20050215541A1

公开(公告)日：2005-09-29

申请号：US10951992

申请日：2004-09-29

申请人： Jing Wu ,  Jay Tung ,  Eugene Thorsett ,  Michael Pleiss ,  Jeffrey Nissen ,  R. Jeffrey Neitz ,  Lee Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas Britton ,  James Audia ,  Jon Reel ,  Thomas Mabry ,  Bruce Dressman ,  Cynthia Cwi ,  James Droste ,  Steven Henry ,  Stacey McDaniel ,  William Scott ,  Russell Stucky ,  Warren Porter

发明人： Jing Wu ,  Jay Tung ,  Eugene Thorsett ,  Michael Pleiss ,  Jeffrey Nissen ,  R. Jeffrey Neitz ,  Lee Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas Britton ,  James Audia ,  Jon Reel ,  Thomas Mabry ,  Bruce Dressman ,  Cynthia Cwi ,  James Droste ,  Steven Henry ,  Stacey McDaniel ,  William Scott ,  Russell Stucky ,  Warren Porter

IPC分类号： A61K31/40 ,  A61K31/4015 ,  A61K31/445 ,  A61K31/55 ,  A61K38/04 ,  A61K38/05 ,  A61P25/28 ,  C07D223/18 ,  C07D471/04 ,  C07D471/06 ,  C07D471/08

CPC分类号： C07D471/04 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/445 ,  A61K31/5513 ,  A61K38/05 ,  C07C237/22 ,  C07C2603/32 ,  C07D223/18 ,  C07D307/33 ,  C07D311/76 ,  C07D471/06 ,  C07D471/08

摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及用这种药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。

公开(公告)号：US20050203080A1

公开(公告)日：2005-09-15

申请号：US10733877

申请日：2003-12-12

申请人： Jing Wu ,  Jay Tung ,  Eugene Thorsett ,  Michael Pleiss ,  Jeffrey Nissen ,  R. Neitz ,  Lee Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas Britton ,  James Audia ,  Jon Reel ,  Thomas Mabry ,  Bruce Dressman ,  Cynthia Cwi ,  James Droste ,  Steven Henry ,  Stacey McDaniel ,  William Scott ,  Russell Stucky ,  Warren Porter

发明人： Jing Wu ,  Jay Tung ,  Eugene Thorsett ,  Michael Pleiss ,  Jeffrey Nissen ,  R. Neitz ,  Lee Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas Britton ,  James Audia ,  Jon Reel ,  Thomas Mabry ,  Bruce Dressman ,  Cynthia Cwi ,  James Droste ,  Steven Henry ,  Stacey McDaniel ,  William Scott ,  Russell Stucky ,  Warren Porter

IPC分类号： A61K31/40 ,  A61K31/4015 ,  A61K31/445 ,  A61K31/55 ,  A61K38/04 ,  A61K38/05 ,  A61P25/28 ,  C07D223/18 ,  C07D471/04 ,  C07D471/06 ,  C07D471/08

CPC分类号： C07D471/04 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/445 ,  A61K31/5513 ,  A61K38/05 ,  C07C237/22 ,  C07C2603/32 ,  C07D223/18 ,  C07D307/33 ,  C07D311/76 ,  C07D471/06 ,  C07D471/08

摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

公开(公告)号：US20050182046A1

公开(公告)日：2005-08-18

申请号：US10777247

申请日：2004-02-13

申请人： Jing Wu ,  Jay Tung ,  Eugene Thorsett ,  Michael Pleiss ,  Jeffrey Nissen ,  R. Neitz ,  Lee Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas Britton ,  James Audia ,  Jon Reel ,  Thomas Mabry ,  Bruce Dressman ,  Cynthia Cwi ,  James Droste ,  Steven Henry ,  Stacey McDaniel ,  William Scott ,  Russell Stucky ,  Warren Porter

发明人： Jing Wu ,  Jay Tung ,  Eugene Thorsett ,  Michael Pleiss ,  Jeffrey Nissen ,  R. Neitz ,  Lee Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas Britton ,  James Audia ,  Jon Reel ,  Thomas Mabry ,  Bruce Dressman ,  Cynthia Cwi ,  James Droste ,  Steven Henry ,  Stacey McDaniel ,  William Scott ,  Russell Stucky ,  Warren Porter

IPC分类号： A61K31/40 ,  A61K31/4015 ,  A61K31/445 ,  A61K31/55 ,  A61K38/04 ,  A61K38/05 ,  A61P25/28 ,  C07D223/18 ,  C07D471/04 ,  C07D471/06 ,  C07D471/08

CPC分类号： C07D471/04 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/445 ,  A61K31/5513 ,  A61K38/05 ,  C07C237/22 ,  C07C2603/32 ,  C07D223/18 ,  C07D307/33 ,  C07D311/76 ,  C07D471/06 ,  C07D471/08

摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及用这种药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。

公开(公告)号：US20060079499A1

公开(公告)日：2006-04-13

申请号：US11001608

申请日：2004-12-02

申请人： Jing Wu ,  Jay Tung ,  Eugene Thorsett ,  Michael Pleiss ,  Jeffrey Nissen ,  R. Neitz ,  Lee Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas Britton ,  James Audia ,  Jon Reel ,  Thomas Mabry ,  Bruce Dressman ,  Cynthia Cwi ,  James Droste ,  Steven Henry ,  Stacey McDaniel ,  William Scott ,  Russell Stucky ,  Warren Porter

发明人： Jing Wu ,  Jay Tung ,  Eugene Thorsett ,  Michael Pleiss ,  Jeffrey Nissen ,  R. Neitz ,  Lee Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas Britton ,  James Audia ,  Jon Reel ,  Thomas Mabry ,  Bruce Dressman ,  Cynthia Cwi ,  James Droste ,  Steven Henry ,  Stacey McDaniel ,  William Scott ,  Russell Stucky ,  Warren Porter

IPC分类号： A61K31/55 ,  A61K31/445

CPC分类号： C07D471/04 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/445 ,  A61K31/5513 ,  A61K38/05 ,  C07C237/22 ,  C07C2603/32 ,  C07D223/18 ,  C07D307/33 ,  C07D311/76 ,  C07D471/06 ,  C07D471/08

摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

公开(公告)号：US20050192265A1

公开(公告)日：2005-09-01

申请号：US11002922

申请日：2004-12-03

申请人： Richard Thompson ,  Stephen Wilkie ,  Douglas Stack ,  Eldon Vanmeter ,  Qing Shi ,  Thomas Britton ,  James Audia ,  Jon Reel ,  Thomas Mabry ,  Bruce Dressman ,  Cynthia Cwi ,  Steven Henry ,  Stacey McDaniel ,  Russell Stucky ,  Warren Porter

发明人： Richard Thompson ,  Stephen Wilkie ,  Douglas Stack ,  Eldon Vanmeter ,  Qing Shi ,  Thomas Britton ,  James Audia ,  Jon Reel ,  Thomas Mabry ,  Bruce Dressman ,  Cynthia Cwi ,  Steven Henry ,  Stacey McDaniel ,  Russell Stucky ,  Warren Porter

IPC分类号： A61K31/445 ,  A61K31/4706 ,  A61K31/473 ,  A61K31/55

CPC分类号： A61K31/445 ,  A61K31/4706 ,  A61K31/473 ,  A61K31/55

摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

公开(公告)号：US20050192269A1

公开(公告)日：2005-09-01

申请号：US11002951

申请日：2004-12-03

申请人： Richard Thompson ,  Stephen Wilkie ,  Douglas Stack ,  Eldon Vanmeter ,  Qing Shi ,  Thomas Britton ,  James Audia ,  Jon Reel ,  Thomas Mabry ,  Bruce Dressman ,  Cynthia Cwi ,  Steven Henry ,  Stacey McDaniel ,  Russell Stucky ,  Warren Porter

发明人： Richard Thompson ,  Stephen Wilkie ,  Douglas Stack ,  Eldon Vanmeter ,  Qing Shi ,  Thomas Britton ,  James Audia ,  Jon Reel ,  Thomas Mabry ,  Bruce Dressman ,  Cynthia Cwi ,  Steven Henry ,  Stacey McDaniel ,  Russell Stucky ,  Warren Porter

IPC分类号： A61K31/445 ,  A61K31/4706 ,  A61K31/501 ,  A61K31/55 ,  A61K38/00 ,  C07D401/12 ,  C07D403/12 ,  C07K5/097

CPC分类号： C07D401/12 ,  A61K38/00 ,  C07D403/12 ,  C07K5/0821 ,  C07K5/0823

摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

公开(公告)号：US20050267150A1

公开(公告)日：2005-12-01

申请号：US11002921

申请日：2004-12-03

申请人： Richard Thompson ,  Stephen Wilkie ,  Douglas Stack ,  Eldon Vanmeter ,  Qing Shi ,  Thomas Britton ,  James Audia ,  Jon Reel ,  Thomas Mabry ,  Bruce Dressman ,  Cynthia Cwi ,  Steven Henry ,  Stacey McDaniel ,  Russell Stucky ,  Warren Porter

发明人： Richard Thompson ,  Stephen Wilkie ,  Douglas Stack ,  Eldon Vanmeter ,  Qing Shi ,  Thomas Britton ,  James Audia ,  Jon Reel ,  Thomas Mabry ,  Bruce Dressman ,  Cynthia Cwi ,  Steven Henry ,  Stacey McDaniel ,  Russell Stucky ,  Warren Porter

IPC分类号： A61K31/445 ,  A61K31/4706 ,  A61K31/501 ,  A61K31/55 ,  A61K38/00 ,  C07D401/12 ,  C07D403/12 ,  C07K5/097

CPC分类号： C07D401/12 ,  A61K38/00 ,  C07D403/12 ,  C07K5/0821 ,  C07K5/0823

摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及预防性和治疗性地用这种药物组合物治疗阿尔茨海默病的方法。

公开(公告)号：US20050261495A1

公开(公告)日：2005-11-24

申请号：US10416771

申请日：2001-11-05

申请人： James Audia ,  Varghese John ,  Lee Latimer ,  Stacey McDaniel ,  Jeffrey Nissen ,  Eugene Thorsett ,  Jay Tung

发明人： James Audia ,  Varghese John ,  Lee Latimer ,  Stacey McDaniel ,  Jeffrey Nissen ,  Eugene Thorsett ,  Jay Tung

IPC分类号： C07D223/16 ,  A61K31/55 ,  A61K38/00 ,  A61P25/28 ,  C07D487/02 ,  C07K5/06

CPC分类号： C07D223/16 ,  A61K38/00 ,  C07K5/06026

摘要： The present invention provides the compound (N)-((S)-2-hydroxy-3-methyl-butyryl)-1-(L-alaninyl)-(S)-1-amino-3-methyl-4,5,6,7-tetrahydro-2H-3-benzazepin-2-one, compositions thereof, and methods for using the same.

摘要翻译： 本发明提供了化合物（N） - （（S）-2-羟基-3-甲基 - 丁酰基）-1-（L-丙氨酰） - （S）-1-氨基-3-甲基-4,5,5- 6,7-四氢-2H-苯并吖庚因-2-酮及其组合物及其使用方法。

公开(公告)号：US06736963B2

公开(公告)日：2004-05-18

申请号：US09918930

申请日：2001-07-31

申请人： Vivek R. Pradhan ,  Ptoshia A. Burnett ,  Stacey McDaniel ,  Michael Hodges

发明人： Vivek R. Pradhan ,  Ptoshia A. Burnett ,  Stacey McDaniel ,  Michael Hodges

IPC分类号： C10G3100

CPC分类号： C10G29/205 ,  C10G29/00 ,  C10G69/123

摘要： Economical processes are disclosed for the production of fuels of reduced sulfur content from a feedstock, typically derived from natural petroleum, wherein the feedstock is comprised of limited amounts of sulfur-containing organic compounds as unwanted impurities. The processes involve an integrated, multiple stage system for converting these impurities to higher boiling products by alkylation and removing the higher boiling products by fractional distillation. Advantageously, the processes include selective hydrogenation of the high-boiling fraction whereby the incorporation of hydrogen into hydrocarbon compounds, sulfur-containing organic compounds, and/or nitrogen-containing organic compounds assists by hydrogenation removal of sulfur and/or nitrogen. Products can be used directly as transportation fuels and/or blending components to provide, for example, more suitable components for blending into fuels which are more friendly to the environment.

摘要翻译： 公开了用于生产通常衍生自天然石油的原料的硫含量降低的燃料的经济方法，其中原料由有限量的含硫有机化合物作为不想要的杂质组成。 该方法涉及通过烷基化将这些杂质转化成较高沸点产物并通过分馏除去较高沸点产物的综合多级体系。 有利地，该方法包括高沸点馏分的选择性氢化，由此通过氢化除去硫和/或氮来帮助将氢引入到烃化合物，含硫有机化合物和/或含氮有机化合物中。 产品可以直接用作运输燃料和/或混合组分，以提供例如更适合的组分用于混合到对环境更友好的燃料中。