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公开(公告)号：US4360041A
公开(公告)日：1982-11-23
申请号：US155213
申请日：1980-06-02
申请人： John D. Hagan , Larry Swanson , David E. Anderson
发明人： John D. Hagan , Larry Swanson , David E. Anderson
CPC分类号： F16L45/00 , Y10T137/4583
摘要： A cleanout fitting for use in the construction industry in conjunction with a lateral sewer line to bring the sewer line up to floor level at various locations to facilitate cleaning of the same. The fitting includes a pipe section with internal threads, a plug member with external threads adapted for engagement with the internal threads of the pipe section, a cover plate positionable on top of the pipe section and a connection member for connecting the cover plate with the plug member.
摘要翻译： 一个清洁配件，用于建筑行业与侧面下水道线连接，以使污水管线在各个位置达到地面水平以便于清洁。 该配件包括具有内螺纹的管段，具有适于与管段的内螺纹接合的外螺纹的塞构件，可定位在管段顶部的盖板和用于将盖板与塞子连接的连接构件 会员。
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2.发明申请COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF MALIGNANT GLIOMAS 审中-公开用于诊断和治疗恶性胶质细胞的组合物和方法公开(公告)号：US20150290306A1
公开(公告)日：2015-10-15
申请号：US14439189
申请日：2013-10-28
申请人： David E. ANDERSON
发明人： David E. Anderson
CPC分类号： A61K39/0011 , A61K2039/552 , A61K2039/55505 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , A61K2039/55577 , A61K2039/585 , G01N33/6866 , G01N33/6869 , G01N2333/5409 , G01N2333/57 , G01N2800/52
摘要： The present application provides compositions and methods useful for the diagnosing and treating malignant gliomas. As described herein, the compositions and methods are based on the development of HLA class II binding peptides and peptide antigens encoded by the MAGE-A3 and IL-13Rα2 tumor associated genes, which stimulate the activity and proliferation of CD4+ T lymphocytes. In embodiments described herein, the compositions may induce a therapeutic response against malignant gliomas.
摘要翻译： 本申请提供了可用于诊断和治疗恶性胶质瘤的组合物和方法。 如本文所述，组合物和方法基于由MAGE-A3和IL-13Rα2肿瘤相关基因编码的HLA II类结合肽和肽抗原的发展，其刺激CD4 + T淋巴细胞的活性和增殖。 在本文所述的实施方案中，组合物可诱导针对恶性胶质瘤的治疗反应。
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公开(公告)号：US20120156240A1
公开(公告)日：2012-06-21
申请号：US13377365
申请日：2010-07-06
申请人： David E. Anderson , Andrei Ogrel
发明人： David E. Anderson , Andrei Ogrel
CPC分类号： A61K39/29 , A61K9/0019 , A61K9/127 , A61K9/1277 , A61K39/12 , A61K39/292 , A61K2039/542 , A61K2039/545 , A61K2039/55555 , A61K2039/55561 , C12N2730/10134 , C12N2770/32434 , Y02A50/464
摘要： The present disclosure provides methods for preparing vesicles. In some embodiments, the methods involve providing a molten mixture of vesicle forming lipids and then adding the molten mixture to an aqueous solution comprising an antigen such that antigen-containing vesicles are formed. In other embodiments, the methods involve providing a lyophilized lipid product and rehydrating the lyophilized lipid product with an aqueous solution comprising an antigen such that antigen-containing vesicles are formed. The lyophilized lipid product is prepared by melting vesicle-forming lipids to produce a molten lipid mixture and then lyophilizing the molten lipid mixture. The present disclosure also provides antigen-containing vesicle formulations prepared using these methods. The present disclosure also provides kits that include a lyophilized lipid product in a first container and an aqueous solution comprising an antigen in a second container.
摘要翻译： 本公开提供了制备囊泡的方法。 在一些实施方案中，所述方法包括提供形成囊泡的脂质的熔融混合物，然后将熔融混合物加入到包含抗原的水溶液中，使得形成含抗原的囊泡。 在其它实施方案中，所述方法包括提供冻干的脂质产物并用包含抗原的水溶液再次水合冻干的脂质产物，使得形成含抗原的囊泡。 冻干的脂质产物通过溶解形成囊泡的脂质以产生熔融脂质混合物，然后将熔融的脂质混合物冻干来制备。 本公开还提供了使用这些方法制备的含抗原的囊泡制剂。 本公开还提供了在第一容器中包含冻干的脂质产物和在第二容器中包含抗原的水溶液的试剂盒。
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4.发明申请SELECTIVE DIFFERENTIATION, IDENTIFICATION, AMD MODULATION OF HUMAN TH17 CELLS 审中-公开人TH17细胞的选择性鉴别，鉴定，AMD调节公开(公告)号：US20110245107A1
公开(公告)日：2011-10-06
申请号：US12863373
申请日：2009-01-21
IPC分类号： C40B40/00 , C12N5/0783 , C12Q1/02 , G01N33/53
CPC分类号： C12N5/0636 , A61K2039/57 , C12N2501/15 , C12N2501/23 , G01N33/505 , G01N2333/4728 , G01N2333/495 , G01N2333/54 , G01N2333/705 , G01N2800/065 , G01N2800/102 , G01N2800/122 , G01N2800/205 , G01N2800/24 , G01N2800/285
摘要： The embodiments provide for the modulation of both the differentiation and activity of human TH17 cells. More specifically, human TH17 cell differentiation can modulated by TGF-? and IL-21, and their agonists and antagonists. Function of TH17 cells can be modulated by, for example, BLT1 or podoplanin, and their agonists and antagonists. Additionally, the embodiments provide for the identification of TH17 cells. More specifically, human TH17 cells specifically upregulate BLT1 and podoplanin.
摘要翻译： 这些实施方案提供对TH17细胞的分化和活性的调节。 更具体地，人TH17细胞分化可以通过TGF- 和IL-21及其激动剂和拮抗剂。 TH17细胞的功能可以由例如BLT1或podoplanin及其激动剂和拮抗剂调节。 另外，这些实施例提供了TH17细胞的鉴定。 更具体地，人TH17细胞特异性上调BLT1和podoplanin。
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公开(公告)号：US09907746B2
公开(公告)日：2018-03-06
申请号：US13377371
申请日：2010-07-06
CPC分类号： A61K9/0019 , A61K9/127 , A61K9/1277 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/55555 , C12N2770/24234
摘要： The present disclosure provides methods for preparing vesicles. In general, these methods include steps of providing a lyophilized lipid product and rehydrating the lyophilized lipid product with an aqueous solution comprising an antigen such that antigen-containing vesicles are formed. The lyophilized lipid product is prepared by dissolving vesicle-forming lipids in a polar-protic water-miscible organic solvent to produce a lipid solution and then lyophilizing the lipid solution. The present disclosure also provides antigen-containing vesicle formulations prepared using these methods. The present disclosure also provides kits that include a lyophilized lipid product in a first container and an aqueous solution comprising an antigen in a second container.
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公开(公告)号：US09849173B2
公开(公告)日：2017-12-26
申请号：US13377365
申请日：2010-07-06
申请人： David E. Anderson , Andrei Ogrel
发明人： David E. Anderson , Andrei Ogrel
CPC分类号： A61K39/29 , A61K9/0019 , A61K9/127 , A61K9/1277 , A61K39/12 , A61K39/292 , A61K2039/542 , A61K2039/545 , A61K2039/55555 , A61K2039/55561 , C12N2730/10134 , C12N2770/32434 , Y02A50/464
摘要： The present disclosure provides methods for preparing vesicles. In some embodiments, the methods involve providing a molten mixture of vesicle forming lipids and then adding the molten mixture to an aqueous solution comprising an antigen such that antigen-containing vesicles are formed. In other embodiments, the methods involve providing a lyophilized lipid product and rehydrating the lyophilized lipid product with an aqueous solution comprising an antigen such that antigen-containing vesicles are formed. The lyophilized lipid product is prepared by melting vesicle-forming lipids to produce a molten lipid mixture and then lyophilizing the molten lipid mixture. The present disclosure also provides antigen-containing vesicle formulations prepared using these methods. The present disclosure also provides kits that include a lyophilized lipid product in a first container and an aqueous solution comprising an antigen in a second container.
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公开(公告)号：US20130295165A1
公开(公告)日：2013-11-07
申请号：US13979322
申请日：2012-01-13
摘要： The present disclosure provides compositions and methods useful for treating viral infections. As described herein, the compositions and methods are based on the development of immunogenic compositions that include an attenuated or inactivated virus in combination with a non-ionic surfactant vesicle (NISV).
摘要翻译： 本公开提供了可用于治疗病毒感染的组合物和方法。 如本文所述，组合物和方法基于免疫原性组合物的开发，其包括与非离子表面活性剂囊泡（NISV）组合的减毒或灭活的病毒。
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公开(公告)号：US20120177683A1
公开(公告)日：2012-07-12
申请号：US13377371
申请日：2010-07-06
CPC分类号： A61K9/0019 , A61K9/127 , A61K9/1277 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/55555 , C12N2770/24234
摘要： The present disclosure provides methods for preparing vesicles. In general, these methods include steps of providing a lyophilized lipid product and rehydrating the lyophilized lipid product with an aqueous solution comprising an antigen such that antigen-containing vesicles are formed. The lyophilized lipid product is prepared by dissolving vesicle-forming lipids in a polar-protic water-miscible organic solvent to produce a lipid solution and then lyophilizing the lipid solution. The present disclosure also provides antigen-containing vesicle formulations prepared using these methods. The present disclosure also provides kits that include a lyophilized lipid product in a first container and an aqueous solution comprising an antigen in a second container.
摘要翻译： 本公开提供了制备囊泡的方法。 通常，这些方法包括提供冻干的脂质产物并且用包含抗原的水溶液将冻干的脂质产物再水合以形成抗原的囊泡的步骤。 冻干的脂质产物通过将溶解泡囊形成的脂质溶解在极性 - 水溶性水溶性有机溶剂中来制备脂质溶液，然后冻干脂质溶液。 本公开还提供了使用这些方法制备的含抗原的囊泡制剂。 本公开还提供了在第一容器中包含冻干的脂质产物和在第二容器中包含抗原的水溶液的试剂盒。
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公开(公告)号：US20070296237A1
公开(公告)日：2007-12-27
申请号：US11767358
申请日：2007-06-22
申请人： David E. Anderson
发明人： David E. Anderson
IPC分类号： B62J17/04
CPC分类号： B62J17/04
摘要： A system and method is provided for a quickly-detachable and replaceable windshield for a recreational vehicle such as a motorcycle. The system may include a fairing that is configured to include a windshield mounting receptacle and rapid attachment hardware that does not require the use of any tools to actuate the hardware. Also included is a windshield configured to engage the rapid attachment hardware upon insertion of the windshield into the windshield mounting receptacle. In use, the windshield is inserted into the windshield mounting receptacle until it engages the rapid attachment hardware, and may be removed and rapidly replaced without the use of any tools by actuating the rapid attachment hardware to release the windshield.
摘要翻译： 提供了一种用于诸如摩托车的休闲车辆的快速可拆卸和可更换的挡风玻璃的系统和方法。 该系统可以包括整流罩，其配置为包括挡风玻璃安装插座和不需要使用任何工具来致动硬件的快速附接硬件。 还包括挡风玻璃，其构造成在将挡风玻璃插入挡风玻璃安装容座时接合快速附接硬件。 在使用中，挡风玻璃被插入挡风玻璃安装插座中，直到其接合快速附接硬件，并且可以通过致动快速附接硬件来释放挡风玻璃而不使用任何工具而被移除并快速地更换。
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公开(公告)号：US4475845A
公开(公告)日：1984-10-09
申请号：US434402
申请日：1982-10-14
申请人： Frank J. Odill , David E. Anderson
发明人： Frank J. Odill , David E. Anderson
IPC分类号： E02D29/12
CPC分类号： E02D29/12 , Y10T403/31
摘要： A cylindrical elastomeric seal is disclosed for externally sealing a manhole assembly against surface water infiltration between the manhole casting and the supporting structure and through the supporting structure. The seal has a first sealing section adapted to receive the edge of the flange of a manhole casting, a second sealing section adapted to be received by the external surface of the manhole chimney or cone, and an intermediate section, joining the two sealing sections, that spans the vertical distance between the casting and the chimney or cone. Sealing means hold the two sealing sections in place against the casting and chimney or cone, creating watertight seals. An extension skirt increases the area the seal can cover, allowing the entire supporting structure to be sealed in the case where the chimney height is too great to be spanned by the intermediate section of the seal alone. The seal can be used on old or new construction and does not interfere with normal use of the manhole.
摘要翻译： 公开了一种圆柱形弹性体密封件，用于外部密封人孔组件，以防止井眼铸件与支撑结构之间的表面水渗入，并穿过支撑结构。 密封件具有适于容纳人孔铸件的凸缘的边缘的第一密封部分，适于由人孔烟囱或锥体的外表面接收的第二密封部分和连接两个密封部分的中间部分， 它跨越铸件和烟囱或锥体之间的垂直距离。 密封装置将两个密封部分固定在铸造和烟囱或锥体上的位置，形成防水密封。 延伸裙增加了密封件可以覆盖的面积，允许整个支撑结构在烟囱高度太大而不能被密封件的中间部分跨越的情况下被密封。 密封件可以用于旧的或新的结构，不会干扰正常使用的人孔。
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