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公开(公告)号：US20050288336A1
公开(公告)日：2005-12-29
申请号：US10514804
申请日：2003-05-14
申请人： Michael Graupe , Agnes Lau , John Link , Yang Liu , Craig Mossman , John Patterson , Sheila Zipfel
发明人： Michael Graupe , Agnes Lau , John Link , Yang Liu , Craig Mossman , John Patterson , Sheila Zipfel
IPC分类号： A61K31/44 , A61K31/4436 , C07D213/56 , C07D263/56 , C07D271/10 , C07D413/12 , C07D417/12 , C07D498/04
CPC分类号： C07D263/56 , C07D271/10 , C07D413/12 , C07D417/12
摘要： The present invention is directed to compounds that are inhibitors of cysteine protease, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
摘要翻译： 本发明涉及半胱氨酸蛋白酶，特别是组织蛋白酶B，K，L，F和S的抑制剂的化合物，因此可用于治疗由这些蛋白酶介导的疾病。 本发明涉及包含这些化合物的药物组合物及其制备方法。
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公开(公告)号：US20070232654A1
公开(公告)日：2007-10-04
申请号：US11758894
申请日：2007-06-06
申请人： John Patterson , Sheila Zipfel
发明人： John Patterson , Sheila Zipfel
IPC分类号： A61K31/44 , A61K31/16 , C07C213/00 , C07D263/52 , C07C233/00 , A61K31/423
CPC分类号： C07D213/40 , C07C255/24 , C07C2601/14 , C07D209/08 , C07D213/64 , C07D213/75 , C07D215/06 , C07D215/12 , C07D217/02 , C07D217/06 , C07D235/14 , C07D263/32 , C07D263/56 , C07D295/185 , C07D307/16 , C07D333/20
摘要： The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
摘要翻译： 本发明涉及新的选择性组织蛋白酶S抑制剂，其药学上可接受的盐和N-氧化物，它们作为治疗剂的用途及其制备方法。
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公开(公告)号：US20060122184A1
公开(公告)日：2006-06-08
申请号：US10536889
申请日：2003-11-26
申请人： Michael Graupe , Agnes Lau , John Link , Yang Liu , Craig Mossman , John Patterson , Sheila Zipfel
发明人： Michael Graupe , Agnes Lau , John Link , Yang Liu , Craig Mossman , John Patterson , Sheila Zipfel
IPC分类号： A61K31/53 , A61K31/50 , A61K31/4965 , A61K31/421 , A61K31/381 , A61K31/277 , A61K31/415
CPC分类号： C07C255/25 , A61K38/00 , C07D211/66 , C07D213/82 , C07D277/30 , C07D333/40 , C07K5/06139
摘要： The present invention is directed to cyanomethyl derivatives that are inhibitors of cysteine protease, in particular, cathepsin B, K, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
摘要翻译： 本发明涉及作为半胱氨酸蛋白酶，特别是组织蛋白酶B，K，F和S的抑制剂的氰甲基衍生物，因此可用于治疗由这些蛋白酶介导的疾病。 本发明涉及包含这些化合物的药物组合物及其制备方法。
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公开(公告)号：US06576630B1
公开(公告)日：2003-06-10
申请号：US09525507
申请日：2000-03-15
申请人： John O. Link , Arnold J. Martelli , Valeri Martichonok , John W. Patterson , Oliver L. Saunders , Sheila Zipfel
发明人： John O. Link , Arnold J. Martelli , Valeri Martichonok , John W. Patterson , Oliver L. Saunders , Sheila Zipfel
IPC分类号： C07D26356
CPC分类号： C07D213/30 , A61K31/42 , A61K31/44 , A61K45/06 , C07D209/08 , C07D263/14 , C07D263/26 , C07D263/32 , C07D263/34 , C07D263/56 , C07D263/60 , C07D307/80 , C07D413/04 , C07D413/12 , C07D413/14 , C07F7/1804 , A61K2300/00
摘要： The present invention relates to novel alkanoyl-substituted heterocyclic derivatives which are cysteine protease inhibitors; the pharmaceutically acceptable salts and N-oxides thereof; their uses as therapeutic agents and the methods of their making.
摘要翻译： 本发明涉及新型烷酰基取代的杂环衍生物，它们是半胱氨酸蛋白酶抑制剂; 其药学上可接受的盐和N-氧化物; 它们作为治疗剂的用途及其制备方法。
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公开(公告)号：US09156823B2
公开(公告)日：2015-10-13
申请号：US13884578
申请日：2011-11-16
申请人： Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
发明人： Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
IPC分类号： C07D403/14 , A61K31/4184 , C07D491/113 , A61K31/5377 , C07D491/107 , A61K31/4188 , A61K31/4178 , A61K45/06 , C07D405/14 , C07D417/14 , C07D471/08 , C07D491/10 , C07D493/04 , C07D495/04 , C07D513/04
CPC分类号： C07D403/14 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61K31/5377 , A61K45/06 , C07D405/14 , C07D417/14 , C07D471/08 , C07D491/10 , C07D491/107 , C07D491/113 , C07D493/04 , C07D495/04 , C07D513/04 , A61K2300/00
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US08530663B2
公开(公告)日：2013-09-10
申请号：US13052273
申请日：2011-03-21
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D213/30 , C07D213/61 , C07D213/74 , C07D307/42 , C07D307/56 , C07D333/16 , C07D405/04 , C07D409/04
摘要： The invention relates to compounds of formula I: where X, HAr, a, and R1 through R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
摘要翻译： 本发明涉及式I化合物：其中X，HAr，a和R 1至R 6如说明书中所定义，或其药学上可接受的盐。 式I化合物是5-羟色胺和去甲肾上腺素再摄取抑制剂。 本发明还涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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![4-[2-(2-FLUOROPHENOXYMETHYL)PHENYL]PIPERIDINE COMPOUNDS](/abs-image/US/2010/05/20/US20100125092A1/abs.jpg.150x150.jpg)
公开(公告)号：US20100125092A1
公开(公告)日：2010-05-20
申请号：US12617821
申请日：2009-11-13
IPC分类号： A61K31/4465 , C07D211/22 , A61P11/06 , A61P25/16 , A61P25/28 , A61P25/24 , G01N33/68
CPC分类号： A61K31/4465 , C07D211/22 , C07D211/32
摘要： The invention relates to compounds of formula I: where a, R1, and R3-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
摘要翻译： 本发明涉及式I化合物：其中a，R 1和R 3-6如说明书中所定义，或其药学上可接受的盐。 式I化合物是5-羟色胺和去甲肾上腺素再摄取抑制剂。 本发明还涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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![4-[2-(2-fluorophenoxy methyl)phenyl]piperidine compounds](/abs-image/US/2015/10/20/US09162982B2/abs.jpg.150x150.jpg)
公开(公告)号：US09162982B2
公开(公告)日：2015-10-20
申请号：US14070887
申请日：2013-11-04
IPC分类号： A61K31/4409 , C07D211/32 , C07D211/22
CPC分类号： A61K31/4465 , C07D211/22 , C07D211/32
摘要： The invention relates to compounds of formula I: where a, R1, and R3-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
摘要翻译： 本发明涉及式I化合物：其中a，R 1和R 3-6如说明书中所定义，或其药学上可接受的盐。 式I化合物是5-羟色胺和去甲肾上腺素再摄取抑制剂。 本发明还涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号：US20140112885A1
公开(公告)日：2014-04-24
申请号：US14049133
申请日：2013-10-08
申请人： Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
发明人： Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
IPC分类号： C07D491/052 , A61K31/7056 , A61K38/21 , A61K31/4188 , A61K45/06
CPC分类号： C07D491/052 , A61K31/4188 , A61K31/7056 , A61K31/7064 , A61K31/7072 , A61K38/06 , A61K38/07 , A61K38/21 , A61K45/06 , A61K47/60 , C07D405/12 , C07F5/025 , Y10S514/894 , A61K2300/00
摘要： The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本公开涉及抗病毒化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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![4-[2-(2-FLUOROPHENOXYMETHYL)PHENYL]PIPERIDINE COMPOUNDS](/abs-image/US/2013/01/31/US20130030020A1/abs.jpg.150x150.jpg)
公开(公告)号：US20130030020A1
公开(公告)日：2013-01-31
申请号：US13631192
申请日：2012-09-28
CPC分类号： A61K31/4465 , C07D211/22 , C07D211/32
摘要： The invention relates to compounds of formula I: where a, R1, and R3-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
摘要翻译： 本发明涉及式I化合物：其中a，R 1和R 3-6如说明书中所定义，或其药学上可接受的盐。 式I化合物是5-羟色胺和去甲肾上腺素再摄取抑制剂。 本发明还涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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