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公开(公告)号：US06576630B1
公开(公告)日：2003-06-10
申请号：US09525507
申请日：2000-03-15
申请人： John O. Link , Arnold J. Martelli , Valeri Martichonok , John W. Patterson , Oliver L. Saunders , Sheila Zipfel
发明人： John O. Link , Arnold J. Martelli , Valeri Martichonok , John W. Patterson , Oliver L. Saunders , Sheila Zipfel
IPC分类号： C07D26356
CPC分类号： C07D213/30 , A61K31/42 , A61K31/44 , A61K45/06 , C07D209/08 , C07D263/14 , C07D263/26 , C07D263/32 , C07D263/34 , C07D263/56 , C07D263/60 , C07D307/80 , C07D413/04 , C07D413/12 , C07D413/14 , C07F7/1804 , A61K2300/00
摘要： The present invention relates to novel alkanoyl-substituted heterocyclic derivatives which are cysteine protease inhibitors; the pharmaceutically acceptable salts and N-oxides thereof; their uses as therapeutic agents and the methods of their making.
摘要翻译： 本发明涉及新型烷酰基取代的杂环衍生物，它们是半胱氨酸蛋白酶抑制剂; 其药学上可接受的盐和N-氧化物; 它们作为治疗剂的用途及其制备方法。
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公开(公告)号：US06492362B1
公开(公告)日：2002-12-10
申请号：US09663449
申请日：2000-09-15
申请人： Michael Graupe , John O. Link , John W. Patterson , Sheila Zipfel
发明人： Michael Graupe , John O. Link , John W. Patterson , Sheila Zipfel
IPC分类号： A61K315375
CPC分类号： C07D213/81 , C07C317/48 , C07C317/50 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07D209/08 , C07D211/66 , C07D213/82 , C07D213/89 , C07D215/48 , C07D215/54 , C07D241/24 , C07D295/185 , C07D295/205 , C07D309/08 , C07D317/68 , C07D333/38 , C07D333/40 , C07D333/70
摘要： The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
摘要翻译： 本发明涉及新的选择性组织蛋白酶S抑制剂，其药学上可接受的盐和N-氧化物，它们作为治疗剂的用途及其制备方法。
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公开(公告)号：US09156823B2
公开(公告)日：2015-10-13
申请号：US13884578
申请日：2011-11-16
申请人： Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
发明人： Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
IPC分类号： C07D403/14 , A61K31/4184 , C07D491/113 , A61K31/5377 , C07D491/107 , A61K31/4188 , A61K31/4178 , A61K45/06 , C07D405/14 , C07D417/14 , C07D471/08 , C07D491/10 , C07D493/04 , C07D495/04 , C07D513/04
CPC分类号： C07D403/14 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61K31/5377 , A61K45/06 , C07D405/14 , C07D417/14 , C07D471/08 , C07D491/10 , C07D491/107 , C07D491/113 , C07D493/04 , C07D495/04 , C07D513/04 , A61K2300/00
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US20140112885A1
公开(公告)日：2014-04-24
申请号：US14049133
申请日：2013-10-08
申请人： Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
发明人： Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
IPC分类号： C07D491/052 , A61K31/7056 , A61K38/21 , A61K31/4188 , A61K45/06
CPC分类号： C07D491/052 , A61K31/4188 , A61K31/7056 , A61K31/7064 , A61K31/7072 , A61K38/06 , A61K38/07 , A61K38/21 , A61K45/06 , A61K47/60 , C07D405/12 , C07F5/025 , Y10S514/894 , A61K2300/00
摘要： The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本公开涉及抗病毒化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20140309432A1
公开(公告)日：2014-10-16
申请号：US14261325
申请日：2014-04-24
申请人： Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
发明人： Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
IPC分类号： C07F5/02 , C07D491/052
CPC分类号： C07D491/052 , A61K31/4188 , A61K31/7056 , A61K31/7064 , A61K31/7072 , A61K38/06 , A61K38/07 , A61K38/21 , A61K45/06 , A61K47/60 , C07D405/12 , C07F5/025 , Y10S514/894 , A61K2300/00
摘要： The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US20140018313A1
公开(公告)日：2014-01-16
申请号：US13884578
申请日：2011-11-16
申请人： Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
发明人： Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
IPC分类号： C07D403/14 , C07D491/113 , A61K31/4188 , C07D491/107 , A61K45/06 , A61K31/4184 , A61K31/5377
CPC分类号： C07D403/14 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61K31/5377 , A61K45/06 , C07D405/14 , C07D417/14 , C07D471/08 , C07D491/10 , C07D491/107 , C07D491/113 , C07D493/04 , C07D495/04 , C07D513/04 , A61K2300/00
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US07064123B1
公开(公告)日：2006-06-20
申请号：US10035783
申请日：2001-12-24
申请人： Michael Graupe , John W. Patterson , Stephen D. Pickett , John O. Link , Jiayao Li , David Aldous , Sukanthini Thurairatnam , Andreas P. Timm , Frank Halley , Justine Lai Yeun Quai
发明人： Michael Graupe , John W. Patterson , Stephen D. Pickett , John O. Link , Jiayao Li , David Aldous , Sukanthini Thurairatnam , Andreas P. Timm , Frank Halley , Justine Lai Yeun Quai
IPC分类号： A61K31/535 , C07D295/00 , A61P29/00
CPC分类号： C07D207/273 , A61K31/5375 , A61K31/5377 , C07C317/44 , C07C323/60 , C07D205/08 , C07D207/24 , C07D213/40 , C07D223/10 , C07D223/12 , C07D263/32 , C07D263/56 , C07D271/06 , C07D271/10 , C07D277/26 , C07D277/64 , C07D285/08 , C07D295/185 , C07D413/04 , C07D413/12 , Y02A50/411
摘要： The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
摘要翻译： 本发明涉及新的选择性组织蛋白酶S抑制剂，其药学上可接受的盐和N-氧化物，它们作为治疗剂的用途及其制备方法。
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公开(公告)号：US20230203071A1
公开(公告)日：2023-06-29
申请号：US18061127
申请日：2022-12-02
申请人： Zhimin Du , Julie Farand , Tezcan Guney , Darryl Kato , John O. Link , James B.C. Mack , Dong Min Mun , William J. Watkins , Jennifer R. Zhang
发明人： Zhimin Du , Julie Farand , Tezcan Guney , Darryl Kato , John O. Link , James B.C. Mack , Dong Min Mun , William J. Watkins , Jennifer R. Zhang
IPC分类号： C07F9/6503 , C07D401/14 , A61K45/06
CPC分类号： C07F9/65038 , C07D401/14 , A61K45/06
摘要： The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of a Retroviridae infection, including an HIV infection.
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公开(公告)号：US20140051626A1
公开(公告)日：2014-02-20
申请号：US13932945
申请日：2013-07-01
申请人： Jeromy J. Cottell , John O. Link , Scott D. Schroeder , James Taylor , Winston C. Tse , Randall W. Vivian , Zheng-Yu Yang
发明人： Jeromy J. Cottell , John O. Link , Scott D. Schroeder , James Taylor , Winston C. Tse , Randall W. Vivian , Zheng-Yu Yang
IPC分类号： C07K5/083
CPC分类号： C07K5/0808 , A61K38/00 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04 , C07K5/0804 , C07K5/0812 , C07K5/0821
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US20130210801A1
公开(公告)日：2013-08-15
申请号：US13806048
申请日：2011-07-01
申请人： Kerim Babaoglu , Kyla Bjornson , Hongyan Guo , Randall L. Halcomb , John O. Link , Hongtao Liu , Michael L. Mitchell , Jianyu Sun , James Taylor , Randall W. Vivian , Lianhong Xu
发明人： Kerim Babaoglu , Kyla Bjornson , Hongyan Guo , Randall L. Halcomb , John O. Link , Hongtao Liu , Michael L. Mitchell , Jianyu Sun , James Taylor , Randall W. Vivian , Lianhong Xu
IPC分类号： C07D498/04 , C07D215/48 , C07D491/052 , C07D215/14
CPC分类号： C07D498/04 , C07D215/06 , C07D215/14 , C07D215/18 , C07D215/20 , C07D215/227 , C07D215/38 , C07D215/48 , C07D401/04 , C07D401/12 , C07D405/04 , C07D413/04 , C07D417/04 , C07D487/04 , C07D491/052 , C07D519/00
摘要： The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula (I).
摘要翻译： 本发明提供了本文所述的式（I）化合物或其盐。 本发明还提供包含式（I）化合物的药物组合物，制备式（I）化合物的方法，用于制备式I化合物的中间体和治疗HIV病毒增殖的治疗方法，治疗AIDS或延迟 使用式（I）化合物在哺乳动物中发生AIDS或ARC症状。
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