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公开(公告)号：US5863930A
公开(公告)日：1999-01-26
申请号：US574082
申请日：1995-12-18
申请人： Jurgen Dressel , Peter Fey , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch , Siegfried Zaiss
发明人： Jurgen Dressel , Peter Fey , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch , Siegfried Zaiss
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/4425 , A61K31/4427 , A61P9/10 , A61P9/12 , C07D213/79 , C07D401/10
CPC分类号： C07D401/10
摘要： Trisubstituted biphenyls are prepared by reacting corresponding pyridones with biphenylmethyl halogen compounds. The trisubstituted biphenyls can be employed as active compounds in medicaments.
摘要翻译： 三取代的联苯通过相应的吡啶酮与联苯基甲基卤化合物反应来制备。 三取代的联苯可用作药物中的活性化合物。
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公开(公告)号：US5407948A
公开(公告)日：1995-04-18
申请号：US239197
申请日：1994-05-06
申请人： Peter Fey , Walter Hubsch , Jurgen Dressel , Rudolf Hanko , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
发明人： Peter Fey , Walter Hubsch , Jurgen Dressel , Rudolf Hanko , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/4427 , A61K31/50 , A61K31/53 , A61P9/10 , A61P9/12 , A61P43/00 , C07D213/60 , C07D213/64 , C07D213/71 , C07D213/76 , C07D213/78 , C07D213/79 , C07D401/10 , C07D401/14
CPC分类号： C07D401/14
摘要： Substituted mono- and bipyridylmethylpyridones are prepared either by reaction of pyridones with mono- or bipyridylmethylhalogen compounds or by reaction of pyridone-substituted halogenopyridines with tetrazolylphenylboronic acids. The substituted mono- and bipyridylmethylpyridones can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
摘要翻译： 取代的单 - 和二吡啶基甲基吡啶酮通过吡啶酮与单吡啶基或联吡啶甲基卤化合物的反应或通过吡啶酮取代的卤代吡啶与四唑基苯基硼酸的反应来制备。 取代的单吡啶基和联吡啶基甲基吡啶酮可用作药物中的活性化合物，特别是用于治疗动脉高血压和动脉粥样硬化。
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公开(公告)号：US5708003A
公开(公告)日：1998-01-13
申请号：US525933
申请日：1995-09-08
申请人： Ulrich E. Muller , Jurgen Dressel , Peter Fey , Rudolf H. Hanko , Walter Hubsch , Thomas Kramer , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch , Siegfried Zaiss
发明人： Ulrich E. Muller , Jurgen Dressel , Peter Fey , Rudolf H. Hanko , Walter Hubsch , Thomas Kramer , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch , Siegfried Zaiss
IPC分类号： C07D403/10 , A61K31/40 , A61K31/403 , A61K31/41 , A61K31/435 , A61K31/44 , A61P9/10 , A61P9/12 , A61P43/00 , C07D209/86 , C07D209/90 , C07D209/94 , C07D213/86 , C07D257/04 , C07D401/10 , C07D471/04
CPC分类号： C07D471/04 , C07D209/86
摘要： Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives are prepared by reacting the heterocyclic compounds with cyclohexanecarboxylic acid derivatives which are substituted by benzyl halide radicals. The compounds can be employed as active compounds in medicaments.
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公开(公告)号：US5492923A
公开(公告)日：1996-02-20
申请号：US235831
申请日：1994-04-29
申请人： Peter Fey , Jurgen Dressel , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
发明人： Peter Fey , Jurgen Dressel , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
IPC分类号： C07D213/60 , A61K31/44 , A61K31/4418 , A61K31/4425 , A61K31/4427 , A61K31/455 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , A61P25/18 , A61P25/24 , A61P25/26 , A61P25/28 , A61P27/02 , A61P43/00 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/84 , C07D401/10
CPC分类号： C07D401/10
摘要： Substituted pyridines and 2-oxo-1,2-dihydropyridines are prepared by reaction of correspondingly substituted halogenobenzenes with tetrazolylboronic acids. The substituted pyridines and 2-oxo-1,2-dihydropyridines according to the invention can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
摘要翻译： 通过相应地取代的卤代苯与四唑基硼酸的反应来制备取代的吡啶和2-氧代-1,2-二氢吡啶。 根据本发明的取代的吡啶和2-氧代-1,2-二氢吡啶可以用作药物中的活性化合物，特别是用于治疗动脉高血压和动脉粥样硬化。
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公开(公告)号：US5356911A
公开(公告)日：1994-10-18
申请号：US970364
申请日：1992-11-02
申请人： Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Stefan Wohlfeil , Walter Hubsch , Jurgen Dressel , Peter Fey , Rudolf Hanko , Thomas Kramer , Ulrich Muller , Siegfried Zaiss
发明人： Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Stefan Wohlfeil , Walter Hubsch , Jurgen Dressel , Peter Fey , Rudolf Hanko , Thomas Kramer , Ulrich Muller , Siegfried Zaiss
IPC分类号： A61K31/41 , A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/4425 , A61K31/4427 , A61K31/4433 , A61K31/455 , A61P9/10 , A61P9/12 , C07D213/64 , C07D213/79 , C07D213/80 , C07D401/10 , C07D401/14 , C07D409/14
CPC分类号： C07D401/10
摘要： Substituted biphenylpyridones can be prepared by alkylating pyridones on the nitrogen. The substituted biphenylpyridones are suitable as active substances in medicaments, in particular in hypotensive and anti-atherosclerotic medicaments.
摘要翻译： 取代的联苯基吡啶酮可以通过在氮上烷基化吡啶酮来制备。 取代的联苯吡啶适合作为药物中的活性物质，特别是低血压和抗动脉粥样硬化药物。
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公开(公告)号：US5318980A
公开(公告)日：1994-06-07
申请号：US18961
申请日：1993-02-18
申请人： Rudolf Hanko , Jurgen Dressel , Peter Fey , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Claudia Hirth-Dietrich , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil , Ozkan Yalkinoglu
发明人： Rudolf Hanko , Jurgen Dressel , Peter Fey , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Claudia Hirth-Dietrich , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil , Ozkan Yalkinoglu
IPC分类号： A61K31/415 , A61K31/40 , A61K31/4427 , A61K31/445 , A61P9/10 , A61P9/12 , A61P43/00 , C07D233/64 , C07D233/68 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , A61K31/535 , A61K31/495
CPC分类号： C07D401/12 , C07D233/68 , C07D403/12
摘要： Sulphonylbenzyl-substituted imidazoles can be prepared by first reacting imidazolylaldehydes with sulphonylbenzyl compounds and then oxidising or reducing the aldehyde function in the customary manner.The sulphonylbenzyl-substituted imidazoles can be used as active compounds in medicaments.
摘要翻译： 磺酰基苄基取代的咪唑可以通过首先使咪唑基醛与磺酰基苄基化合物反应，然后以常规方式氧化或还原醛官能团来制备。 磺酰苄基取代的咪唑可用作药物中的活性化合物。
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7.发明授权Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives 失效异环取代的苯基 - 环己烷羧酸衍生物
公开(公告)号：US5834481A
公开(公告)日：1998-11-10
申请号：US889683
申请日：1997-07-08
申请人： Ulrich E. Muller , Jurgen Dressel , Peter Fey , Rudolf H. Hanko , Walter Hubsch , Thomas Kramer , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch , Siegfried Zaiss
发明人： Ulrich E. Muller , Jurgen Dressel , Peter Fey , Rudolf H. Hanko , Walter Hubsch , Thomas Kramer , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch , Siegfried Zaiss
IPC分类号： C07D403/10 , A61K31/40 , A61K31/403 , A61K31/41 , A61K31/435 , A61K31/44 , A61P9/10 , A61P9/12 , A61P43/00 , C07D209/86 , C07D209/90 , C07D209/94 , C07D213/86 , C07D257/04 , C07D401/10 , C07D471/04 , C07D209/82
CPC分类号： C07D471/04 , C07D209/86
摘要： Heterotricyclically substituted phenyl-cyclohexanecarboxylic acid derivatives are prepared by reacting the heterocyclic compounds with cyclohexanecarboxylic acid derivatives which are substituted by benzyl halide radicals. The compounds can be employed as active compounds in medicaments.
摘要翻译： 异环取代的苯基 - 环己烷羧酸衍生物通过使杂环化合物与被苄基卤基取代的环己烷羧酸衍生物反应来制备。 这些化合物可以用作药物中的活性化合物。
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公开(公告)号：US5527809A
公开(公告)日：1996-06-18
申请号：US187925
申请日：1994-01-27
申请人： Matthias Muller-Gliemann , Jurgen Dressel , Peter Fey , Rudolf H. Hanko , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch , Siegfried Zaiss
发明人： Matthias Muller-Gliemann , Jurgen Dressel , Peter Fey , Rudolf H. Hanko , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch , Siegfried Zaiss
IPC分类号： A61K31/415 , A61K31/4184 , A61K31/435 , A61P9/10 , A61P9/12 , A61P43/00 , C07D235/06 , C07D235/08 , C07D235/16 , C07D235/18 , C07D471/04
CPC分类号： C07D471/04 , C07D235/08 , C07D235/18
摘要： Substituted imidazo[4,5-b]pyridines and benzimidazoles are prepared by reacting imidazo[4,5-b]pyridines or benzimidazoles with appropriately substituted benzyl halides. The substituted imidazo[4,5-b]pyridines or benzimidazoles can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
摘要翻译： 通过咪唑并[4,5-b]吡啶或苯并咪唑与适当取代的苄基卤反应制备取代的咪唑并[4,5-b]吡啶和苯并咪唑。 取代的咪唑并[4,5-b]吡啶或苯并咪唑可用作药物中的活性化合物，特别是用于治疗动脉高血压和动脉粥样硬化。
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9.发明授权Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives 失效异环取代的苯基 - 环己烷羧酸衍生物
公开(公告)号：US5478836A
公开(公告)日：1995-12-26
申请号：US212609
申请日：1994-03-11
申请人： Ulrich E. Muller , Jurgen Dressel , Peter Fey , Rudolf H. Hanko , Walter Hubsch , Thomas Kramer , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch , Siegfried Zaiss
发明人： Ulrich E. Muller , Jurgen Dressel , Peter Fey , Rudolf H. Hanko , Walter Hubsch , Thomas Kramer , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch , Siegfried Zaiss
IPC分类号： C07D403/10 , A61K31/40 , A61K31/403 , A61K31/41 , A61K31/435 , A61K31/44 , A61P9/10 , A61P9/12 , A61P43/00 , C07D209/86 , C07D209/90 , C07D209/94 , C07D213/86 , C07D257/04 , C07D401/10 , C07D471/04
CPC分类号： C07D471/04 , C07D209/86
摘要： Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives are prepared by reacting the heterocyclic compounds with cyclohexanecarboxylic acid derivatives which are substituted by benzyl halide radicals. The compounds can be employed as active compounds in medicaments.
摘要翻译： 异环取代的苯基 - 环己烷羧酸衍生物通过使杂环化合物与被苄基卤基取代的环己烷羧酸衍生物反应来制备。 这些化合物可以用作药物中的活性化合物。
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公开(公告)号：US5712296A
公开(公告)日：1998-01-27
申请号：US549381
申请日：1995-10-27
申请人： Peter Fey , Jurgen Dressel , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
发明人： Peter Fey , Jurgen Dressel , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
IPC分类号： C07D213/60 , A61K31/44 , A61K31/4418 , A61K31/4425 , A61K31/4427 , A61K31/455 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , A61P25/18 , A61P25/24 , A61P25/26 , A61P25/28 , A61P27/02 , A61P43/00 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/84 , C07D401/10
CPC分类号： C07D401/10
摘要： Substituted pyridines and 2-oxo-1,2-dihydropyridines are prepared by reaction of correspondingly substituted halogenobenzenes with tetrazolylboronic acids. The substituted pyridines and 2-oxo-1,2-dihydropyridines according to the invention can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
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