公开(公告)号：US20240003864A1

公开(公告)日：2024-01-04

申请号：US18036418

申请日：2021-11-24

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Tom Johannes Van Gijsel ,  Lucas Johannes Anna Maria Beckers ,  Sergei Y. Shulepov ,  Suzanne Maaike Valster ,  Job Lipsch

IPC: G01N33/483 ,  C12M3/00

CPC classification number: G01N33/4833 ,  C12M21/08

Abstract: A device for testing in vitro tissue comprises a base section and a structure protruding from the base section. The shape and/or cross section of the structure varies with the height of the structure relative to the base section as measured from a height direction, perpendicular to the base section.

公开(公告)号：US10923099B2

公开(公告)日：2021-02-16

申请号：US15309493

申请日：2015-04-30

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Lucas Johannes Anna Maria Beckers ,  Peter Dirksen ,  Nico Maris Adriaan de Wild ,  Franciscus Johannes Gerardus Hakkens

IPC: G01K11/30 ,  G10K11/30 ,  A61B8/00 ,  G01N29/24 ,  A61B8/08

Abstract: An acoustical lens (20) for an ultrasound probe (14) is disclosed. The acoustical lens comprises an inner surface (26) for facing an emission surface (46) of an ultrasound transducer (40) and for receiving ultrasound waves from the ultrasound transducer. The acoustical lens further comprises an outer surface (24) for emitting the ultrasound waves received at the inner surface, wherein the inner surface is formed as a convexly curved surface and wherein at least one recess (34) is associated to an edge of the inner surface for capturing mold material.

公开(公告)号：US20200163647A1

公开(公告)日：2020-05-28

申请号：US16637013

申请日：2018-08-08

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Franciscus Johannes Gerardus Hakkens ,  Lucas Johannes Anna Maria Beckers ,  Edward Theodorus Maria Berben

IPC: A61B8/00

Abstract: A wearable patch (10) is disclosed comprising an ultrasound transducer (30) mounted on the patch and a fluid reservoir (50) for containing a coupling agent (60) for the ultrasound transducer, said fluid reservoir being delimited by a portion (20) of the patch and a seal ring (40) extending from the patch, said seal ring surrounding the ultrasound transducer and comprising a plurality of fluid conduits (43, 45) extending from the fluid reservoir at least partially through the seal ring. Also disclosed are a wearable patch kit, assembly and application method.

公开(公告)号：US20250129319A1

公开(公告)日：2025-04-24

申请号：US18689172

申请日：2022-09-21

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Lucas Johannes Anna Maria Beckers ,  Renatus Hendricus Maria Sanders

IPC: C12M1/12

Abstract: Provided is a method (100) of fabricating a polymer membrane (206) suitable for a cell culture device. The method comprises providing (102) a first polymer (200) having a first surface (201), and providing (104) a solution (204) on the first surface. The solution comprises a second polymer, a surfactant, and a solvent. The surfactant comprises surfactant molecules each having a polar moiety. The method further comprises evaporating (106) the solvent while the solution is on the first surface to provide the polymer membrane. The polymer membrane has a second surface (207) in contact with the first surface. At least the first surface of the first polymer has greater affinity for the polar moiety than the second polymer. Further provided is the polymer membrane per se, a fluidic device, such as a cell culture device, comprising such a polymer membrane, and a cell culturing method comprising encapsulating cells with one or more of the polymer membrane.

公开(公告)号：US20220387996A1

公开(公告)日：2022-12-08

申请号：US17775954

申请日：2020-11-13

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Lucas Johannes Anna Maria Beckers

IPC: B01L3/00

Abstract: A fluidic device (1) comprises a flow chamber (2) for accommodating a biological specimen on a carrier portion (3) and at least one flow channel (4a, 4b, 4c, 4d) fluidly connected to the flow chamber (2), the fluidic device (1) having a layered structure comprising a bottom plate (5), a cover plate (6) and an insert (7) in between, the insert (7) comprising the carrier portion (3) and a frame portion surrounding the carrier portion (3), and being elastomeric in order to be able to clamp a biological specimen between an incision in the carrier portion (3).

公开(公告)号：US11386883B2

公开(公告)日：2022-07-12

申请号：US16062656

申请日：2016-12-16

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Peter Dirksen ,  Sergei Shulepov ,  Franciscus Johannes Gerardus Hakkens ,  Petrus Henricus Maria Timmermans ,  Lucas Johannes Anna Maria Beckers

IPC: G01K11/30 ,  G10K11/30 ,  B06B1/02 ,  A61B8/00 ,  G01N29/22 ,  G01N29/24

Abstract: An acoustic lens suitable for a CMUT array (74) is provided. The acoustic lens comprising: a first layer (47) comprising a thermoset elastomer having a polymeric material selected from hydrocarbons, wherein the first layer has an inner surface (72) arranged to face the array and an outer convex shaped surface (40) arranged to oppose the inner surface; and a second layer (42) coupled to the outer surface of the first layer and comprising thermoplastic polymer polymethylpentene and an elastomer selected from the polyolefin family (POE) blended therein, wherein the outer layer located at the outer surface of the acoustic window layer, wherein the first layer has a first acoustic wave velocity (v1) and the second layer has a second acoustic wave velocity (v2), said second velocity is larger than the first acoustic wave velocity.

公开(公告)号：US12241082B2

公开(公告)日：2025-03-04

申请号：US16630872

申请日：2018-07-06

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Lucas Johannes Anna Maria Beckers ,  Jan Cornelis Kriege

IPC: C12N5/00 ,  C07K14/47 ,  C12M1/00 ,  C12M1/12 ,  C12M1/42 ,  C12M3/00 ,  C12N5/071 ,  C12Q3/00 ,  G16B5/20

Abstract: A material for binding to a cell culturing protein is disclosed. The material contains a bulk-modified elastomer comprising a plurality of fatty acid moieties covalently bound to the elastomer bulk, wherein the carboxylic acid groups of said moieties are available to provide said binding. Also disclosed are a fluidic device module, a cell culturing scaffold, a fluidic device, the method of synthesizing such a material and a drug testing method. With such a material, a (monolithic) fluidic device module may be manufactured in as few as a single step injection molding process.

公开(公告)号：US11627938B2

公开(公告)日：2023-04-18

申请号：US16329048

申请日：2017-08-22

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Lucas Johannes Anna Maria Beckers ,  Vincent Adrianus Henneken

IPC: A61B8/00 ,  B06B1/02 ,  A61B8/08 ,  G10K11/02 ,  C09D109/00 ,  C09D7/48 ,  A61B8/12

Abstract: An imaging device (100) is disclosed comprising an ultrasound transducer array (101, 120, 130) having a plurality of ultrasound transducer elements defining an ultrasound emitting surface of the ultrasound transducer array; and an acoustic window (220) on the ultrasound emitting surface, said acoustic window comprising: a first layer (221) of a hydrocarbon elastomer contacting the ultrasound emitting surface, said first layer further containing an antioxidant; and a second layer (223) of a further hydrocarbon elastomer on the first layer, said second layer having a greater Shore A hardness than the first layer. Also disclosed are an ultrasound imaging system (10) comprising such an imaging device, such as catheter (100), and a method (300) of forming an acoustic window (220) on an ultrasound transducer array (101, 120, 130) for such a device (100).

公开(公告)号：US11543393B2

公开(公告)日：2023-01-03

申请号：US16495156

申请日：2018-03-20

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Lucas Johannes Anna Maria Beckers ,  Johan Hendrik Klootwijk

IPC: G01N30/02 ,  G01N30/60 ,  G01N33/00 ,  G01N33/497 ,  G01N30/88

Abstract: A 3D gas chromatography (GC) column development is possible by assembly of two parts each being substrates formed by gas tight materials. One part may be a silicon substrate with a snake shaped flow channel structure and the other part may be a glass plate. Both are coated with a column packing comprising polubutadiene, which is also able to glue or bond both parts together, thereby sealing the flow channel, thus forming a GC column. The column packaging can be composed in all kinds of polarity from very hydrophobic till very hydrophilic. In this way the column packing can be tuned on resolution for particular molecules which are interesting to detect, e.g. Octane. The invention is advantageous for micro GC columns.

公开(公告)号：US20200289087A1

公开(公告)日：2020-09-17

申请号：US16649259

申请日：2018-09-13

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Lucas Johannes Anna Maria Beckers ,  Franciscus Johannes Gerardus Hakkens ,  Edward Theodorus Maria Berben ,  Timon Rutger Grob

IPC: A61B8/00

Abstract: A wearable patch (10) comprising an ultrasound transducer (30) mounted on the patch, the ultrasound transducer comprising a major surface for contacting the skin of a wearer of the patch, said major surface being covered by a layer (33) of a soluble adhesive precursor, the wearable patch further comprising a seal ring (40) extending from the patch, said seal ring surrounding the ultrasound transducer. Also disclosed are a wearable patch kit, assembly and application method.