公开(公告)号：US20180116996A1

公开(公告)日：2018-05-03

申请号：US15795971

申请日：2017-10-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kyungsu KANG ,  Yongsoo CHOI ,  Cheol-Ho PAN ,  Sang Min KIM ,  Kwang-Hyun CHA ,  Jin-Chul KIM

IPC: A61K31/336 ,  A61K36/03 ,  A23L33/105

Abstract: Provided is a pharmaceutical composition, a health food composition, or a quasi drug composition for preventing, treating, or improving a disease caused by overproduction of dihydrotestosterone, including fucoxanthin or a Phaeodactylum tricornutum extract as an active ingredient.

公开(公告)号：US20180059075A1

公开(公告)日：2018-03-01

申请号：US15685510

申请日：2017-08-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Yongsoo CHOI ,  Jeongsook SHIN ,  Cheol-Ho PAN ,  Sang Min KIM ,  Jung-Seok YANG ,  Kyungsu KANG ,  Sang Hoon JUNG

IPC: G01N30/72 ,  G01N30/06

CPC classification number: G01N30/7233 ,  G01N30/06 ,  G01N2030/027 ,  G01N2030/067 ,  G01N2030/8818

Abstract: Provided is an amine group-derivatized composition including a Boc compound for liquid chromatography-mass spectrometry (LC-MS) analysis, and when the amine group-derivatized composition is used in analysis using reverse-phase LC-MS, it is possible to effectively analyze compounds including an amine group and an amino acid at a low cost in a short time.

公开(公告)号：US20200342957A1

公开(公告)日：2020-10-29

申请号：US16857765

申请日：2020-04-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Keunwan PARK ,  Cheol-Ho PAN ,  Young-Joon KO ,  Prasannavenkatesh DURAI ,  Yongsoo CHOI ,  Moon-Hyeong SEO ,  Kyungsu KANG ,  Jin Soo PARK ,  Jaeyoung KWON

IPC: G16B20/30 ,  G16B40/20 ,  G16B15/30

Abstract: The present invention relates to an ensemble evolutionary chemical binding similarity (ensECBS) model, which is a chemical binding similarity searching method widely applicable as a powerful tool for representing an unknown relationship between chemicals by using evolutionary information of proteins binding to chemicals.

公开(公告)号：US20170340690A1

公开(公告)日：2017-11-30

申请号：US15596404

申请日：2017-05-16

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Cheol-Ho PAN ,  Kyungsu KANG ,  Kwang-Hyun CHA ,  Eun Ha LEE ,  Hee Ju LEE ,  Song Yi KOO ,  Yongsoo CHOI

IPC: A61K36/344 ,  A23L33/135 ,  C12N1/20 ,  A61K35/741 ,  A61K35/00

CPC classification number: A61K36/344 ,  A23L33/135 ,  A23V2002/00 ,  A61K35/741 ,  A61K2035/115 ,  C12N1/20

Abstract: Disclosed is a method for improving intestinal microflora, which includes administering an extract of Codonopsis lanceolata of an amount effective for improving intestinal microflora to a subject in need thereof. The extract can promote the proliferation of beneficial intestinal bacteria and suppress the proliferation of harmful bacteria. Also, the extract can improve intestinal health or intestinal function and improve defecation disorder. In addition, a synergic effect can be obtained when the composition of the present disclosure is used together with probiotics.

公开(公告)号：US20210202039A1

公开(公告)日：2021-07-01

申请号：US17139031

申请日：2020-12-31

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Keunwan PARK ,  Cheol-Ho PAN ,  Moon-Hyeong SEO ,  Dae-geun SONG ,  Chulhee KWAK

IPC: G16B30/10

Abstract: The present invention relates to a method for designing an optimized mutant protein sequence using amino acid co-evolutionary information. Specifically, the present invention relates to a method for searching a protein having a novel mutant sequence with improved expression level, water solubility, stability, and functionality, while maintaining the original function of the protein, using amino acid co-evolutionary information and information on protein tertiary structure.

公开(公告)号：US20200000866A1

公开(公告)日：2020-01-02

申请号：US16212030

申请日：2018-12-06

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  REPUBLIC OF KOREA(MANAGEMENT : RURAL DEVELOPMENT ADMINISTRATION)

Inventor： Jung Kyung MOON ,  Man Soo CHOI ,  Soo Kwon PARK ,  Nam Hee JEONG ,  Yongsoo CHOI ,  Sungdo HA ,  Cheol-Ho PAN ,  Sung Taeg KANG ,  Soon Chun JEONG

IPC: A61K36/48 ,  A01H5/10 ,  A01H6/54 ,  A61P39/06 ,  A61P1/16

Abstract: Provided are a seed of new soybean cultivar SCEL-1, a plant body of the seed or a part of the plant body, and an extract obtained from the seed.