公开(公告)号：US20200148746A1

公开(公告)日：2020-05-14

申请号：US16475052

申请日：2017-12-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun-ee KOH ,  Eun Jung LEE ,  Yoo Soo YANG ,  In-San KIM

IPC: C07K14/71 ,  C12N9/12 ,  A61P35/00

Abstract: The present invention provides a recombinant exosome and uses thereof. More particularly, the present invention privides a recombinant exosome wherein a phagocytosis promoting protein is presented on the surface thereof.

公开(公告)号：US20240189435A1

公开(公告)日：2024-06-13

申请号：US18551271

申请日：2022-12-13

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Yoo Soo YANG ,  Sun Hwa KIM ,  Ick Chan KWON ,  Eun Hye KIM

IPC: A61K47/64 ,  A61K47/54 ,  A61P35/00 ,  C12N15/11

CPC classification number: A61K47/64 ,  A61K47/545 ,  A61P35/00 ,  C12N15/11 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/16 ,  C12N2310/315 ,  C12N2310/3231 ,  C12N2310/351 ,  C12N2310/3529 ,  C12N2310/531 ,  C12N2330/00

Abstract: Disclosed is an agent capable of inhibiting the activity or enhancing expression of various cancer-related RNAs in TAMS and cancer cells. Disclosed is also a dual-targeted drug delivery system capable of binding to both tumor cells and macrophages in which the PD-L1 receptor is overexpressed.

公开(公告)号：US20220251170A1

公开(公告)日：2022-08-11

申请号：US17712155

申请日：2022-04-03

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun-ee KOH ,  Eun Jung LEE ,  Yoo Soo YANG ,  In-San KIM

IPC: C07K14/71 ,  A61P35/00 ,  C12N9/12

Abstract: The present invention provides a recombinant exosome and uses thereof. More particularly, the present invention provides a recombinant exosome wherein a phagocytosis promoting protein is presented on the surface of the exosome.

公开(公告)号：US20180028600A1

公开(公告)日：2018-02-01

申请号：US15650272

申请日：2017-07-14

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Yeon-Sun HONG ,  Yoo Soo YANG ,  Cherl Hyun JEONG ,  In-San KIM

IPC: A61K38/16 ,  A61K45/06 ,  A61K9/127

CPC classification number: A61K38/162 ,  A61K9/1271 ,  A61K45/06 ,  A61P3/10 ,  A61P21/00

Abstract: Provided is a recombinant exosome, and more specifically, to a recombinant exosome obtained from a eukaryotic cell transfected for the expression of a glucose transporter protein (GLUT) and a membrane fusogenic protein, and use thereof.

公开(公告)号：US20240358645A1

公开(公告)日：2024-10-31

申请号：US18652504

申请日：2024-05-01

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Yeon-Sun HONG ,  Yoo Soo YANG ,  In-San KIM

IPC: A61K9/48 ,  A61K31/337 ,  A61K31/407 ,  A61K31/704 ,  A61K38/47 ,  A61K39/395 ,  A61K41/00 ,  A61K45/06 ,  A61N5/10 ,  A61P35/00

CPC classification number: A61K9/48 ,  A61K31/337 ,  A61K31/407 ,  A61K31/704 ,  A61K38/47 ,  A61K39/3955 ,  A61K41/0057 ,  A61K45/06 ,  A61P35/00 ,  C12Y302/01035 ,  A61N5/10 ,  A61N2005/1098

Abstract: The present invention relates to a recombinant exosome containing hyaluronidase and a use thereof, and more particularly to a recombinant exosome that presents hyaluronidase on its surface and use thereof as an anticancer agent.

公开(公告)号：US20210054047A1

公开(公告)日：2021-02-25

申请号：US17013245

申请日：2020-09-04

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Min-Woo KIH ,  Eun Jung LEE ,  Yoo Soo YANG ,  Cherl Hyun JEONG ,  In-San KIM ,  Soyoun KIM

IPC: C07K14/705 ,  A61P35/00

Abstract: The present invention relates to a novel anticancer fusion protein and use thereof, and more particularly, provides a fusion protein in which a tumor necrosis factor (TNF) superfamily protein is linked to a self-assembled protein, which is capable of forming a protein nanocage by self-assembly of the self-assembled protein.