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公开(公告)号：US5270313A
公开(公告)日：1993-12-14
申请号：US869274
申请日：1992-04-15
申请人： Kaspar Burri , Martine Clozel , Walter Fischli , Georges Hirth , Bernd M. Loffler , Henri Ramuz
发明人： Kaspar Burri , Martine Clozel , Walter Fischli , Georges Hirth , Bernd M. Loffler , Henri Ramuz
IPC分类号： A61K31/505 , A61K31/495 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/48 , C07D239/69 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/12
CPC分类号： C07D401/12 , C07D239/69 , C07D405/12 , C07D409/12 , C07D413/10
摘要： Sulfonamides of formula I, in which the symbols R.sup.1 -R.sup.6, X, Y and n have the significance given in the description and which are in part novel compounds, and salts thereof, which can be used as active ingredients for the manufacture of medicaments for the treatment of circulatory disorders, especially hypertension, ischemia, vasospasms and angina pectoris, are described.
摘要翻译： 式I的磺酰胺，其中符号R1-R6，X，Y和n具有在说明书中给出的并且部分新化合物的含义及其盐，其可以用作制备药物的活性成分 描述了循环系统疾病，特别是高血压，局部缺血，血管痉挛和心绞痛的治疗。
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公开(公告)号：US5292740A
公开(公告)日：1994-03-08
申请号：US896015
申请日：1992-06-09
申请人： Kaspar Burri , Martine Clozel , Walter Fischli , Georges Hirth , Bernd-Michael Loffler , Werner Neidhart , Henri Ramuz
发明人： Kaspar Burri , Martine Clozel , Walter Fischli , Georges Hirth , Bernd-Michael Loffler , Werner Neidhart , Henri Ramuz
IPC分类号： A61K31/505 , A61K20060101 , A61K31/18 , A61K31/63 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P25/04 , A61P25/06 , C07C311/15 , C07D20060101 , C07D239/42 , C07D239/46 , C07D239/48 , C07D239/52 , C07D239/56 , C07D239/58 , C07D239/69 , C07D311/20 , C07D401/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D407/14 , C07D409/04 , C07D409/14 , C07D413/12 , C07D403/04 , C07D239/47 , C07D401/14 , C07D403/14 , C07D413/04
CPC分类号： C07D239/47 , C07D239/69 , C07D401/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D407/14 , C07D409/04 , C07D409/14 , C07D413/10
摘要： The novel sulfonamides of formula I, ##STR1## in which the symbols R.sup.1 -R.sup.9, R.sup.a, R.sup.b, X, Y and n have the significance given in the description and salts thereof can be used for the treatment of circulatory disorders, especially hypertension, ischemia, vasopasms and angina pectoris.
摘要翻译： 其中符号R1-R9，Ra，Rb，X，Y和n具有在其描述中给出的含义及其盐的式I的新型磺酰胺，其中符号R1-R9，Ra，Rb，X，Y和n可用于治疗循环系统疾病，特别是高血压 ，缺血，血管扩张和心绞痛。
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公开(公告)号：US20080064740A1
公开(公告)日：2008-03-13
申请号：US11572801
申请日：2005-07-20
申请人： Martin Bolli , Daniel Bur , Martine Clozel , Walter Fischli , David Lehmann , Boris Mathys , Claus Mueller , Oliver Nayler , Michael Scherz , Thomas Weller
发明人： Martin Bolli , Daniel Bur , Martine Clozel , Walter Fischli , David Lehmann , Boris Mathys , Claus Mueller , Oliver Nayler , Michael Scherz , Thomas Weller
IPC分类号： A61K31/381 , A61P37/00 , C07D333/78
CPC分类号： C07D333/78 , C07D409/12
摘要： The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.
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公开(公告)号：US20070244156A1
公开(公告)日：2007-10-18
申请号：US11756008
申请日：2007-05-31
申请人： Hamed Aissaoui , Martine Clozel , Walter Fischli , Ralf Koberstein , Thierry Sifferlen , Thomas Weller
发明人： Hamed Aissaoui , Martine Clozel , Walter Fischli , Ralf Koberstein , Thierry Sifferlen , Thomas Weller
IPC分类号： A61K31/18 , A61K31/4184 , A61K31/44 , A61K31/473
CPC分类号： C07C311/21 , A61K31/18 , A61K31/4184 , A61K31/44 , A61K31/473 , C07C311/13 , C07C311/20 , C07C311/29 , C07C2601/02 , C07C2601/14 , C07D207/323 , C07D209/14 , C07D213/40 , C07D213/53 , C07D213/71 , C07D213/74 , C07D213/75 , C07D215/12 , C07D215/36 , C07D215/38 , C07D217/02 , C07D231/56 , C07D233/64 , C07D277/28 , C07D401/12 , C07D401/14 , C07D417/12
摘要： The invention relates to novel sulfonylamino-acetic acid derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.
摘要翻译： 本发明涉及新型磺酰基氨基 - 乙酸衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备这些化合物的方法，包含一种或多种这些化合物的药物组合物，特别是其作为食欲素受体拮抗剂的用途的相关方面。
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公开(公告)号：US07094781B2
公开(公告)日：2006-08-22
申请号：US10433041
申请日：2001-12-04
申请人： Martin Bolli , Christoph Boss , Walter Fischli , Martine Clozel , Thomas Weller
发明人： Martin Bolli , Christoph Boss , Walter Fischli , Martine Clozel , Thomas Weller
IPC分类号： C07D401/04 , C07D239/47 , A61K31/506
CPC分类号： C07D239/47 , C07D239/52 , C07D239/56 , C07D239/60 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/14
摘要： The invention relates to novel sulfamides and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as endothelin receptor antagonists.
摘要翻译： 本发明涉及新型磺酰胺及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为内皮素受体拮抗剂的用途的相关方面。
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公开(公告)号：US06951856B2
公开(公告)日：2005-10-04
申请号：US10332247
申请日：2001-07-10
申请人： Christoph Boss , Martin Bolli , Martine Clozel , Walter Fischli , Thomas Weller
发明人： Christoph Boss , Martin Bolli , Martine Clozel , Walter Fischli , Thomas Weller
IPC分类号： C07D239/47 , A61K31/505 , A61K31/506 , A61K31/5377 , A61P3/10 , A61P9/10 , A61P9/12 , A61P11/06 , A61P25/06 , A61P29/00 , A61P35/00 , A61P43/00 , C07D239/00 , C07D239/46 , C07D239/52 , C07D239/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , A61K31/535
CPC分类号： C07D239/47 , C07D239/46 , C07D239/52 , C07D239/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D407/14 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The invention relates to novel aryl-ethene-sulfonamides and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as endothelin receptor antagonists.
摘要翻译： 本发明涉及新的芳基 - 乙烯磺酰胺及其作为药物组合物制备中的活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为内皮素受体拮抗剂的用途的相关方面。
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公开(公告)号：US07285549B2
公开(公告)日：2007-10-23
申请号：US11400697
申请日：2006-04-07
申请人： Martin Bolli , Christoph Boss , Walter Fischli , Martine Clozel , Thomas Weller
发明人： Martin Bolli , Christoph Boss , Walter Fischli , Martine Clozel , Thomas Weller
IPC分类号： C07D401/04 , C07D239/47
CPC分类号： C07D239/47 , C07D239/52 , C07D239/56 , C07D239/60 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/14
摘要： The invention relates to novel sulfamides and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as endothelin receptor antagonists.
摘要翻译： 本发明涉及新型磺酰胺及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为内皮素受体拮抗剂的用途的相关方面。
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公开(公告)号：US20070191424A1
公开(公告)日：2007-08-16
申请号：US10598449
申请日：2005-02-23
IPC分类号： A61K31/4709 , A61K31/47 , C07D401/02
CPC分类号： C07D217/18 , C07D401/06
摘要： The invention relates to novel 1,2,3,4-tetrahydroisoquinoline derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, phannaceutical compositions containing one or more of those compounds and methods of treatment comprising administration of said compounds to a mammal.
摘要翻译： 本发明涉及新型1,2,3,4-四氢异喹啉衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物和包括向哺乳动物施用所述化合物的治疗方法的相关方面。
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公开(公告)号：US20070167472A1
公开(公告)日：2007-07-19
申请号：US10537400
申请日：2003-11-10
申请人： Martin Bolli , Christoph Boss , Martine Clozel , Walter Fischli , Thomas Weller
发明人： Martin Bolli , Christoph Boss , Martine Clozel , Walter Fischli , Thomas Weller
IPC分类号： A61K31/513 , C07D403/02 , C07D239/47
CPC分类号： C07D239/47 , C07D239/52 , C07D239/56
摘要： The invention relates to novel sulfamic acid amides of General Formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as endothelin receptor antagonists.
摘要翻译： 本发明涉及通式（I）的新型氨基磺酰胺及其作为制备药物组合物的活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为内皮素受体拮抗剂的用途的相关方面。
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10.发明授权Benzazepines and related heterocyclic derivatives which are useful as orexin receptor antagonists 失效苯并氮杂类和相关杂环衍生物，可用作食欲素受体拮抗剂公开(公告)号：US07192950B2
公开(公告)日：2007-03-20
申请号：US10450420
申请日：2001-12-19
申请人： Hamed Aissaoui , Martine Clozel , Thomas Weller , Ralf Koberstein , Thierry Sifferlen , Walter Fischli
发明人： Hamed Aissaoui , Martine Clozel , Thomas Weller , Ralf Koberstein , Thierry Sifferlen , Walter Fischli
IPC分类号： A61P3/04 , A61K31/55 , C07D223/16
CPC分类号： C07D223/16 , A61K31/55 , C07D243/14 , C07D267/14 , C07D281/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The invention relates to novel benzazepines and related heterocyclic derivatives (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.
摘要翻译： 本发明涉及新的苯并氮杂和相关杂环衍生物（I）及其作为药物组合物制备中的活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为食欲素受体拮抗剂的用途的相关方面。
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