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公开(公告)号：US07276582B2
公开(公告)日：2007-10-02
申请号：US11283193
申请日：2005-11-18
申请人： Katsuhiko Mikoshiba , Junji Hirota , Hideaki Ando
发明人： Katsuhiko Mikoshiba , Junji Hirota , Hideaki Ando
CPC分类号： A61K38/1709 , C07K14/4702
摘要： Analysis of substance capable of binding with inositol-1, 4,5-triphosphate (IP3) receptor (IP3R), preferably with a regulation domain of IP3R; analysis of the function of IP3R; and establishing of a method of treatment or diagnosis for various malfunctions and diseases associated with IP3R. In particular, control of the activity of intracellular Ca2+ release. More specifically, a regulator for the activity of inositol-1,4, 5-triphosphate (IP3) receptor (IP3R), comprised of carbonic anhydrase related protein (CARP); a control agent for intracellular calsium release, comprised of carbonic anhydrase related protein (CARP); and a method of control therewith.
摘要翻译： 分析能够与肌醇-1,4,5-三磷酸（IP 3 N 3）受体（IP 3 R R）结合的物质，优选具有IP
3 < 分析IP 3的功能; 以及建立与IP 3 R相关的各种故障和疾病的治疗或诊断方法。 特别地，控制细胞内Ca 2+释放的活性。 更具体地，由碳酸酐酶相关蛋白质（肌醇-1,5,5-三磷酸（IP 3 N 3 R））的肌醇-1,4,5-三磷酸（IP 3 N 3 R）活性调节剂 鲤鱼）; 由碳酸酐酶相关蛋白（CARP）组成的用于细胞内钙离子释放的控制剂; 及其控制方法。 -
公开(公告)号：US07709441B2
公开(公告)日：2010-05-04
申请号：US11811588
申请日：2007-06-11
申请人： Katsuhiko Mikoshiba , Junji Hirota , Hideaki Ando
发明人： Katsuhiko Mikoshiba , Junji Hirota , Hideaki Ando
CPC分类号： A61K38/1709 , C07K14/4702
摘要： Analysis of substance capable of binding with inositol-1,4,5-triphosphate (IP3) receptor (IP3R), preferably with a regulation domain of IP3R; analysis of the function of IP3R; and establishing of a method of treatment or diagnosis for various malfunctions and diseases associated with IP3R. In particular, control of the activity of intracellular Ca2+ release. More specifically, a regulator for the activity of inositol-1,4,5-triphosphate (IP3) receptor (IP3R), comprised of carbonic anhydrase related protein (CARP); a control agent for intracellular calcium release, comprised of carbonic anhydrase related protein (CARP); and a method of control therewith.
摘要翻译： 分析能够与肌醇-1,4,5-三磷酸（IP3）受体（IP3R）结合的物质，优选具有IP3R的调节结构域; 分析IP3R的功能; 并建立与IP3R相关的各种故障和疾病的治疗或诊断方法。 特别是控制细胞内Ca2 +释放的活性。 更具体地，由碳酸酐酶相关蛋白（CARP）组成的肌醇-1,4,5-三磷酸（IP3）受体（IP3R）的活性调节剂; 由碳酸酐酶相关蛋白（CARP）组成的细胞内钙释放控制剂; 及其控制方法。
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公开(公告)号：US20080064082A1
公开(公告)日：2008-03-13
申请号：US11811588
申请日：2007-06-11
申请人： Katsuhiko Mikoshiba , Junji Hirota , Hideaki Ando
发明人： Katsuhiko Mikoshiba , Junji Hirota , Hideaki Ando
IPC分类号： C12N1/00
CPC分类号： A61K38/1709 , C07K14/4702
摘要： Analysis of substance capable of binding with inositol-1,4,5-triphosphate (IP3) receptor (IP3R), preferably with a regulation domain of IP3R; analysis of the function of IP3R; and establishing of a method of treatment or diagnosis for various malfunctions and diseases associated with IP3R. In particular, control of the activity of intracellular Ca2+ release. More specifically, a regulator for the activity of inositol-1,4,5-triphosphate (IP3) receptor (IP3R), comprised of carbonic anhydrase related protein (CARP); a control agent for intracellular calcium release, comprised of carbonic anhydrase related protein (CARP); and a method of control therewith.
摘要翻译： 分析能够与肌醇-1,4,5-三磷酸（IP 3 N 3）受体（IP 3 R R）结合的物质，优选具有IP
3 < 分析IP 3的功能; 以及建立与IP 3 R相关的各种故障和疾病的治疗或诊断方法。 特别地，控制细胞内Ca 2+释放的活性。 更具体地，由碳酸酐酶相关蛋白质（肌醇-1,5,5-三磷酸（IP 3 N 3 R））的肌醇-1,4,5-三磷酸（IP 3 N 3 R）的活性调节剂 鲤鱼）; 由碳酸酐酶相关蛋白（CARP）组成的细胞内钙释放控制剂; 及其控制方法。 -
公开(公告)号：US20060166880A1
公开(公告)日：2006-07-27
申请号：US11283193
申请日：2005-11-18
申请人： Katsuhiko Mikoshiba , Junji Hirota , Hideaki Ando
发明人： Katsuhiko Mikoshiba , Junji Hirota , Hideaki Ando
CPC分类号： A61K38/1709 , C07K14/4702
摘要： Analysis of substance capable of binding with inositol-1,4,5-triphosphate (IP3) receptor (IP3R), preferably with a regulation domain of IP3R; analysis of the function of IP3R; and establishing of a method of treatment or diagnosis for various malfunctions and diseases associated with IP3R. In particular, control of the activity of intracellular Ca2+ release. More specifically, a regulator for the activity of inositol-1,4,5-triphosphate (IP3) receptor (IP3R), comprised of carbonic anhydrase related protein (CARP); a control agent for intracellular calsium release, comprised of carbonic anhydrase related protein (CARP); and a method of control therewith.
摘要翻译： 分析能够与肌醇-1,4,5-三磷酸（IP 3 N 3）受体（IP 3 R R）结合的物质，优选具有IP
3 < 分析IP 3的功能; 以及建立与IP 3 R相关的各种故障和疾病的治疗或诊断方法。 特别地，控制细胞内Ca 2+释放的活性。 更具体地，由碳酸酐酶相关蛋白质（肌醇-1,5,5-三磷酸（IP 3 N 3 R））的肌醇-1,4,5-三磷酸（IP 3 N 3 R）的活性调节剂 鲤鱼）; 由碳酸酐酶相关蛋白（CARP）组成的用于细胞内钙离子释放的控制剂; 及其控制方法。 -
5.发明申请公开(公告)号：US20100167314A1
公开(公告)日：2010-07-01
申请号：US12293681
申请日：2007-03-20
摘要： The present invention provides a composition comprising an IP3 receptor-binding protein (IRBIT), a nucleic acid that controls the expression and translation of IRBIT, or an antibody against IRBIT for controlling at least one intracellular biological function selected from the group consisting of (1) protein synthesis, (2) phosphatidylinositol metabolism, and (3) intracellular pH.
摘要翻译： 本发明提供一种组合物，其包含IP3受体结合蛋白（IRBIT），控制IRBIT的表达和翻译的核酸或针对IRBIT的抗体，用于控制至少一种选自下组的细胞内生物学功能：（1 ）蛋白质合成，（2）磷脂酰肌醇代谢，和（3）细胞内pH。
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6.发明授权In vitro control of protein synthesis in mammalian cells by IP3 receptor-binding protein 有权通过IP3受体结合蛋白体外控制哺乳动物细胞中的蛋白质合成公开(公告)号：US08252547B2
公开(公告)日：2012-08-28
申请号：US12293681
申请日：2007-03-20
IPC分类号： A61K38/00 , A61K31/7088 , C07K14/47 , C12Q1/02 , G01N33/15
摘要： The present invention provides a composition comprising an IP3 receptor-binding protein (IRBIT), a nucleic acid that controls the expression and translation of IRBIT, or an antibody against IRBIT for controlling at least one intracellular biological function selected from the group consisting of (1) protein synthesis, (2) phosphatidylinositol metabolism, and (3) intracellular pH.
摘要翻译： 本发明提供了包含IP3受体结合蛋白（IRBIT），控制IRBIT的表达和翻译的核酸或针对IRBIT的抗体的组合物，用于控制至少一种细胞内生物学功能，所述细胞内生物学功能选自（1 ）蛋白质合成，（2）磷脂酰肌醇代谢，和（3）细胞内pH。
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7.发明申请Novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein and an IP3 indicator 审中-公开新型肌醇1,4,5-三磷酸（IP3）受体结合蛋白和IP3指示剂公开(公告)号：US20050181450A1
公开(公告)日：2005-08-18
申请号：US10683610
申请日：2003-10-10
IPC分类号： G01N33/53 , C07K14/47 , C07K14/705 , C07K16/18 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/02 , G01N21/78 , G01N33/566 , G01N33/58 , C07H21/04 , C12N9/16
CPC分类号： C07K14/47
摘要： The present invention provides a novel IP3 receptor-binding protein that is used as an indicator effective for detecting and quantifying IP3, and a method for detecting and/or quantifying IP3 using the same. Determined is an IP3 receptor-binding protein, particularly a novel IP3 receptor-binding protein, IRBIT, which interacts with an IP3 receptor, and whose interaction is regulated by IP3. IRBIT has the characteristic that it can be dissociated from the IP3 receptor by IP3 at a physiological concentration. Because of this characteristic, IRBIT can be useful as an indicator for detecting IP3 by the FRET method or the like.
摘要翻译： 本发明提供了一种新的IP 3受体结合蛋白，其被用作用于检测和定量IP 3的有效指标，以及用于检测和/或定量IP的方法 3 使用它们。 确定的是IP 3受体结合蛋白，特别是新的IP 3受体结合蛋白IRBIT，其与IP 3受体相互作用 ，并且其相互作用由IP 3限制。 IRBIT具有其生理浓度可以通过IP 3 N 3从IP 3受体分离的特征。 由于该特性，IRBIT可以用作通过FRET方法等检测IP 3的指示符。
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公开(公告)号：US20060019261A1
公开(公告)日：2006-01-26
申请号：US10943015
申请日：2004-09-17
CPC分类号： G01N33/6896 , A61K38/00 , C07K14/47
摘要： The present invention provides Synaptotagmin-binding and yet RNA-binding proteins and genes encoding the proteins. The invention relates to a recombinant protein selected from the group consisting of the following (a) and (b), as well as a gene encoding the protein: (a) a protein comprising the amino acid sequence as shown in SEQ ID NO: 2 (b) a protein which comprises the amino acid sequence as shown in SEQ ID NO: 2 having deletion, substitution or addition of one or several amino acids and which has RNA binding activity.
摘要翻译： 本发明提供了Synaptotagmin结合蛋白和编码蛋白质的RNA结合蛋白和基因。 本发明涉及选自以下（a）和（b）的重组蛋白质，以及编码该蛋白质的基因：（a）包含SEQ ID NO：2所示的氨基酸序列的蛋白质 （b）包含SEQ ID NO：2所示的具有缺失，取代或添加一个或几个氨基酸并具有RNA结合活性的氨基酸序列的蛋白质。
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公开(公告)号：US06921648B2
公开(公告)日：2005-07-26
申请号：US10244367
申请日：2002-09-16
CPC分类号： C07K14/463
摘要： The present invention relates to neurogenesis inducing genes. In particular, the present invention provides neurogenesis inducing genes coding for Zic proteins, vectors containing such genes, host cells containing such vectors, proteins produced by such host cells, antibodies raised to such proteins, and therapeutic agents or agents for gene therapy for nervous diseases.
摘要翻译： 本发明涉及神经发生诱导基因。 特别地，本发明提供了编码Zic蛋白质的神经发生诱导基因，含有这些基因的载体，含有该载体的宿主细胞，由该宿主细胞产生的蛋白质，产生于该蛋白质的抗体，以及用于神经疾病基因治疗的治疗剂或药剂 。
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公开(公告)号：US08853424B2
公开(公告)日：2014-10-07
申请号：US13058647
申请日：2009-08-11
申请人： Katsuhiko Mikoshiba , Nobuyuki Nukina , Shoichiro Ozaki , Kouzo Hamada , Jun-Ichi Goto , Akinobu Suzuki , Etsuko Ebisui , Akiko Terauchi
发明人： Katsuhiko Mikoshiba , Nobuyuki Nukina , Shoichiro Ozaki , Kouzo Hamada , Jun-Ichi Goto , Akinobu Suzuki , Etsuko Ebisui , Akiko Terauchi
IPC分类号： C07D333/00 , A61K31/67 , C07F5/02 , A61K31/69
摘要： The present invention provides a protein cross-linking inhibitor containing a compound represented by any of the following formulas (1)-(13), or a pharmaceutically acceptable salt thereof: R3—[—X—B(ZR1)—Y—B(ZR2)—W—]n—R4, (1) R3—[—X—B(ZR1)—Y—]n—R4, (2) R3—[—B(ZR1)—Y—B(ZR2)—W—]n—R4, (3) R3—[—X—B(ZR1)—]n—R4, (4) R3—[—B(ZR2)—W—]n—R4, (5) R3—X—B(ZR1)-T[B(ZR2)—W—R4]2, (6) R3—B(OH)2, (7) R3—B(ZR1)—X—B(ZR2)—R4, (8) R3—B(R1)—O—B(R2)—R4, (9) R3—[—X—B(ZR1)—Y—B(ZR2)—]n—R4, (10) R3—[—X—B(ZR1)—Y—B(ZR2)—W-Q-]n—R4, (11) R3—[—P—X—B(ZR1)—Y—B(ZR2)—W—]n—R4, (12) [R3—X—B(ZR1)—Y]2B(ZR2), (13) wherein each symbol is as defined in the DESCRIPTION.
摘要翻译： 本发明提供一种蛋白质交联抑制剂，其含有下述式（1） - （13）中任一项所示的化合物或其药学上可接受的盐：R3 - [ - X-B（ZR1）-Y-B ZR2）-W-] n-R4，（1）R3 - [ - X-B（ZR1）-Y-] n-R4，（2）R3 - [ - B（ZR1）-Y-B（ZR2） - W - ] n-R4，（3）R3 - [ - X-B（ZR1） - ] n-R4，（4）R3 - [ - B（ZR2）-W-] n-R4，（5） X-B（ZR1）-T [B（ZR2）-W-R4] 2，（6）R3-B（OH）2，（7）R3-B（ZR1）-X-B（ZR2）-R4， （8）R3-B（R1）-O-B（R2）-R4，（9）R3 - [ - X-B（ZR1）-Y-B（ZR2） - ] n-R4，（10） [-X-B（ZR1）-Y-B（ZR2）-WQ-] n-R4，（11）R3 - [ - P-X-B（ZR1）-Y-B（ZR2）-W-] n -R4，（12）[R3-X-B（ZR1）-Y] 2B（ZR2），（13）其中每个符号如说明书中所定义。
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