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    CELL-ADHERING LIGHT-CONTROLLABLE SUBSTRATE
    1.
    发明申请
    CELL-ADHERING LIGHT-CONTROLLABLE SUBSTRATE 审中-公开
    细胞附着的光控基材

    公开(公告)号：US20140099695A1

    公开(公告)日：2014-04-10

    申请号：US14111150

    申请日：2012-04-11

    申请人： Toshiaki Furuta ,  Akinobu Suzuki ,  Hisashi Sugiyama ,  Satoshi Ozawa ,  Hiroko Tada

    发明人： Toshiaki Furuta ,  Akinobu Suzuki ,  Hisashi Sugiyama ,  Satoshi Ozawa ,  Hiroko Tada

    IPC分类号： C12N11/08 ,  C12M1/00

    CPC分类号： C12N11/08 ,  C12M25/06 ,  C12M33/00 ,  C12M41/36 ,  C12M47/02 ,  C12N1/02 ,  C12N5/0068 ,  C12N11/06 ,  C12N2529/10 ,  C12N2539/10

    摘要： An object of the present invention is to enable simpler operation in real time and culture while removing unnecessary cells from cultured cells for purification in analyzing, fractionating, and culturing the cells alive and to analyze and fractionate desired cells from the cultured cells to increase the purity, recovery rate, and viability of the cells. The present invention employs a cell-adhesive photocontrollable base material, wherein light irradiation causes the bond dissociation of a photolabile group comprising a coumarinylmethyl skeleton to produce the separation of a cell-adhesive material to leave a non-cell-adhesive material. As a result, cell images can be detected and analyzed to obtain the positional information of desired cells. Based on the positional information thus obtained, the cells can be analyzed and fractionated alive.

    摘要翻译： 本发明的目的是使得能够实时和培养更简单的操作，同时从培养细胞中除去不需要的细胞以进行分析，分级和培养细胞，并从培养的细胞中分析和分离所需细胞以增加纯度 ，回收率和细胞存活率。 本发明采用细胞粘合剂可光控制的基材，其中光照射导致包含香豆素甲基骨架的光不稳定基团的键解离以产生细胞粘合剂材料的分离以留下非细胞粘合剂材料。 结果，可以检测和分析细胞图像以获得所需细胞的位置信息。 基于这样获得的位置信息，可以对细胞进行分析和分离。

    PROTEIN CROSS-LINKING INHIBITOR
    2.
    发明申请
    PROTEIN CROSS-LINKING INHIBITOR 有权
    蛋白交联抑制剂

    公开(公告)号：US20110212919A1

    公开(公告)日：2011-09-01

    申请号：US13058647

    申请日：2009-08-11

    申请人： Katsuhiko Mikoshiba ,  Nobuyuki Nukina ,  Shoichiro Ozaki ,  Kouzo Hamada ,  Jun-Ichi Goto ,  Akinobu Suzuki ,  Etsuko Ebisui ,  Akiko Terauchi

    发明人： Katsuhiko Mikoshiba ,  Nobuyuki Nukina ,  Shoichiro Ozaki ,  Kouzo Hamada ,  Jun-Ichi Goto ,  Akinobu Suzuki ,  Etsuko Ebisui ,  Akiko Terauchi

    IPC分类号： A61K31/69 ,  C07F5/02 ,  C07F5/04 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61P27/12 ,  A61P3/00 ,  A61P17/00 ,  A61P7/00

    CPC分类号： C07F5/025 ,  A61K31/69

    摘要： The present invention provides a protein cross-linking inhibitor containing a compound represented by any of the following formulas (1)-(13), or a pharmaceutically acceptable salt thereof: R3—[—X—B(ZR1)—Y—B(ZR2)—W—]n—R4,  (1) R3—[—X—B(ZR1)—Y—]n—R4,  (2) R3—[—B(ZR1)—Y—B(ZR2)—W—]n—R4,  (3) R3—[—X—B(ZR1)—]n—R4,  (4) R3—[—B(ZR2)—W—]n—R4,  (5) R3—X—B(ZR1)-T[B(ZR2)—W—R4]2,  (6) R3—B(OH)2,  (7) R3—B(ZR1)—X—B(ZR2)—R4,  (8) R3—B(R1)—O—B(R2)—R4,  (9) R3—[—X—B(ZR1)—Y—B(ZR2)—]n—R4,  (10) R3—[—X—B(ZR1)—Y—B(ZR2)—W-Q-]n—R4,  (11) R3—[—P—X—B(ZR1)—Y—B(ZR2)—W—]n—R4,  (12) [R3—X—B(ZR1)—Y]2B(ZR2),  (13) wherein each symbol is as defined in the DESCRIPTION.

    摘要翻译： 本发明提供一种蛋白质交联抑制剂，其含有下述式（1） - （13）中任一项所示的化合物或其药学上可接受的盐：R3 - [ - X-B（ZR1）-Y-B ZR2）-W-] n-R4，（1）R3 - [ - X-B（ZR1）-Y-] n-R4，（2）R3 - [ - B（ZR1）-Y-B（ZR2） - W - ] n-R4，（3）R3 - [ - X-B（ZR1） - ] n-R4，（4）R3 - [ - B（ZR2）-W-] n-R4，（5） X-B（ZR1）-T [B（ZR2）-W-R4] 2，（6）R3-B（OH）2，（7）R3-B（ZR1）-X-B（ZR2）-R4， （8）R3-B（R1）-O-B（R2）-R4，（9）R3 - [ - X-B（ZR1）-Y-B（ZR2） - ] n-R4，（10） [-X-B（ZR1）-Y-B（ZR2）-WQ-] n-R4，（11）R3 - [ - P-X-B（ZR1）-Y-B（ZR2）-W-] n -R4，（12）[R3-X-B（ZR1）-Y] 2B（ZR2），（13）其中每个符号如说明书中所定义。

    Optical semiconductor module using dummy ferrule
    3.
    发明授权
    Optical semiconductor module using dummy ferrule 失效
    光学半导体模块采用虚拟套圈

    公开(公告)号：US4875752A

    公开(公告)日：1989-10-24

    申请号：US155517

    申请日：1988-02-12

    申请人： Akinobu Suzuki

    发明人： Akinobu Suzuki

    IPC分类号： G02B6/38 ,  G02B6/42 ,  G02B6/36

    CPC分类号： G02B6/4292 ,  G02B6/3877

    摘要： An optical semiconductor module comprises an optical semiconductor assembly having a light transmitting aperture, a housing having a joint surface at its one end to be joined to the optical semiconductor assembly, an outer male screw portion and a first hole for receiving an optical fiber supporter at its other end, a lens held in a second hole formed in the housing so as to be in communicatively alignment with the light transmitting aperture and the first hole, wherein a slitted sleeve is placed in a hole communicated with the first hole and a dummy ferrule with an axially extendly central bore for passing light is placed between the first hole and the lens so that one end portion of the dummy ferrule is inserted in the slitted sleeve so as to be in contact with the optical fiber supporter when it is fitted.

    NOVEL BISBORON COMPOUND
    6.
    发明申请
    NOVEL BISBORON COMPOUND 有权
    新颖的BISBONON化合物

    公开(公告)号：US20100087645A1

    公开(公告)日：2010-04-08

    申请号：US12094968

    申请日：2006-11-24

    申请人： Katsuhiko Mikoshiba ,  Shoichiro Ozaki ,  Akinobu Suzuki ,  Takeshi Nakamura

    发明人： Katsuhiko Mikoshiba ,  Shoichiro Ozaki ,  Akinobu Suzuki ,  Takeshi Nakamura

    IPC分类号： C07F5/02

    CPC分类号： C07F5/025

    摘要： A bisboron compound represented by the general formula (I): wherein B represents a boron atom, Y represents an oxygen or sulfur atom, R1 and R2 independently represent a monocyclic aromatic group, a polycyclic aromatic group, or a heterocyclic group containing at least one heteroatom selected from oxygen, nitrogen and sulfur atoms, R3 represents a hydrogen atom; —(CH2)m—NR4R5; —CO—(CH2)m—NR4R5; —COCH(NH2)R6; —CHR7R8; —CH2CH(NH2)—R9; quinolyl substituted with C1-C4 alkyl group; or C1-C4 alkyl substituted with pyridyl, piperidino or pyrrolidinyl group, and X represents a monocyclic aromatic group, a polycyclic aromatic group or a heterocyclic group, which may be the same as or different from R1 and R2, or a bifunctional group having a monocyclic aromatic group, polycyclic aromatic group or heterocyclic group bonded to each side of a group selected from the group consisting of a single bond, O, CH2, S, SO2, CH2OCH2, OCH2, OCH2CH2OCH2, OCH2OCH2CH2 and CH2OCH2CH2, or a salt thereof, and a composition for controlling the intracellular calcium concentration, which comprises the compound or salt thereof as an active ingredient.

    摘要翻译： 由通式（I）表示的双硼化合物：其中B表示硼原子，Y表示氧或硫原子，R1和R2独立地表示单环芳基，多环芳基或含有至少一个 选自氧，氮和硫原子的杂原子，R 3表示氢原子; - （CH 2）m -NR 4 R 5; -CO-（CH 2）m -NR 4 R 5; -COCH（NH 2）R 6; -CHR7R8; -CH 2 CH（NH 2）-R 9; 被C1-C4烷基取代的喹啉基; 或被吡啶基，哌啶子基或吡咯烷基取代的C1-C4烷基，X表示可以与R1和R2相同或不同的单环芳基，多环芳基或杂环基，或具有 或选自由单键，O，CH2，S，SO2，CH2OCH2，OCH2，OCH2CH2OCH2，OCH2OCH2CH2和CH2OCH2CH2组成的组中的一个基团键合的单环芳基，多环芳基或杂环基，或其盐， 以及用于控制细胞内钙浓度的组合物，其包含其化合物或其盐作为活性成分。

    Electronic device with coaxial connectors for high-frequency circuit board
    7.
    发明授权
    Electronic device with coaxial connectors for high-frequency circuit board 失效
    具有高频电路板同轴连接器的电子设备

    公开(公告)号：US06373710B1

    公开(公告)日：2002-04-16

    申请号：US09497160

    申请日：2000-02-03

    申请人： Akinobu Suzuki

    发明人： Akinobu Suzuki

    IPC分类号： H05K500

    CPC分类号： H05K7/142 ,  H01R24/52

    摘要： Electronic devices are provided with a high-frequency circuit board and a coaxial connector connected to external high-frequency signals to the circuit board. The lead terminal of the coaxial connector is directly soldered to a land on the circuit board to enable high-frequency signal transmission. The fixing portion, which is on one side of the circuit board and apart from the coaxial connector, has a structure such that the horizontal tension of the circuit board is relaxed. In this mounting method, repetitive tension due to differences in linear expansion coefficient does not act on the soldered portion.

    摘要翻译： 电子设备配有高频电路板和连接到电路板的外部高频信号的同轴连接器。 同轴连接器的引线端子直接焊接到电路板上的焊盘，以实现高频信号传输。 位于电路板的一侧并且与同轴连接器分离的固定部分具有使电路板的水平张力松弛的结构。 在这种安装方法中，由于线膨胀系数的差异引起的重复张力不会对焊接部分起作用。

    Bisboron compound
    8.
    发明授权
    Bisboron compound 有权
    Bisboron化合物

    公开(公告)号：US08017809B2

    公开(公告)日：2011-09-13

    申请号：US12094968

    申请日：2006-11-24

    申请人： Katsuhiko Mikoshiba ,  Shoichiro Ozaki ,  Akinobu Suzuki ,  Takeshi Nakamura ,  Kyoko Nakamura, legal representative ,  Aiko Nakamura, legal representative

    发明人： Katsuhiko Mikoshiba ,  Shoichiro Ozaki ,  Akinobu Suzuki ,  Takeshi Nakamura

    IPC分类号： C07F5/02 ,  A61K31/69

    CPC分类号： C07F5/025

    摘要： A bisboron compound represented by the general formula (I): wherein B represents a boron atom, Y represents an oxygen or sulfur atom, R1 and R2 independently represent a monocyclic aromatic group, a polycyclic aromatic group, or a heterocyclic group containing at least one heteroatom selected from oxygen, nitrogen and sulfur atoms, R3 represents a hydrogen atom; —(CH2)m—NR4R5; —CO—(CH2)m—NR4R5; —COCH(NH2)R6; —CHR7R8; —CH2CH(NH2)—R9; quinolyl substituted with C1-C4 alkyl group; or C1-C4 alkyl substituted with pyridyl, piperidino or pyrrolidinyl group, and X represents a monocyclic aromatic group, a polycyclic aromatic group or a heterocyclic group, which may be the same as or different from R1 and R2, or a bifunctional group having a monocyclic aromatic group, polycyclic aromatic group or heterocyclic group bonded to each side of a group selected from the group consisting of a single bond, O, CH2, S, SO2, CH2OCH2, OCH2, OCH2CH2OCH2, OCH2OCH2CH2 and CH2OCH2CH2, or a salt thereof, and a composition for controlling the intracellular calcium concentration, which comprises the compound or salt thereof as an active ingredient.

    摘要翻译： 由通式（I）表示的双硼化合物：其中B表示硼原子，Y表示氧或硫原子，R1和R2独立地表示单环芳基，多环芳基或含有至少一个 选自氧，氮和硫原子的杂原子，R 3表示氢原子; - （CH 2）m -NR 4 R 5; -CO-（CH 2）m -NR 4 R 5; -COCH（NH 2）R 6; -CHR7R8; -CH 2 CH（NH 2）-R 9; 被C1-C4烷基取代的喹啉基; 或被吡啶基，哌啶子基或吡咯烷基取代的C1-C4烷基，X表示可以与R1和R2相同或不同的单环芳基，多环芳基或杂环基，或具有 或选自由单键，O，CH2，S，SO2，CH2OCH2，OCH2，OCH2CH2OCH2，OCH2OCH2CH2和CH2OCH2CH2组成的组中的一个基团键合的单环芳基，多环芳基或杂环基，或其盐， 以及用于控制细胞内钙浓度的组合物，其包含其化合物或其盐作为活性成分。

    Method of fabricating an optical package
    10.
    发明授权
    Method of fabricating an optical package 失效
    制造光学包装的方法

    公开(公告)号：US5127074A

    公开(公告)日：1992-06-30

    申请号：US651757

    申请日：1991-02-07

    申请人： Hideki Watanabe ,  Yuji Sakazaki ,  Akinobu Suzuki

    发明人： Hideki Watanabe ,  Yuji Sakazaki ,  Akinobu Suzuki

    IPC分类号： G02B6/42 ,  H01L31/0232

    CPC分类号： G02B6/4292 ,  G02B6/4225 ,  G02B6/4237

    摘要： An optical package includes a housing composed of two sections, a first section and a second section connectable to the first section. A laser holder is connected to the first section of the housing and adapted to hold a laser assembly. A fiber holder is connected to the second section of the housing and includes a ferrule by which an optical fiber is held. A rod lens is mounted within the housing to focus optical emission from the laser assembly on the optical fiber. The laser assembly includes a semiconductor element. Radial alignment of the semiconductor element and the laser holder is performed before the laser holder is secured to the first section of the housing. Axial alignment of the rod lens and the semiconductor element takes place while the laser holder is being fit in the first section of the housing. The second section of the housing is then moved in a radial direction relative to the optical axis of the semiconductor element and is, then, laser welded to the first section of the housing.