摘要:
A failure detection protocol is applied so that failure detection requests for the same aggregated link can be processed even when the failure detection requests differ among routing protocols. The failure detection protocol is executed for each of the physical links that form an aggregated link, and a notification is sent to a higher-level application (for example, a routing protocol), which is a requesting source of a communication line failure monitoring request, with a discrimination between a case in which the communication of the aggregated link in its entirety fails and a case in which some physical links of the aggregated link fail.
摘要:
A failure detection protocol is applied so that failure detection requests for the same aggregated link can be processed even when the failure detection requests differ among routing protocols. The failure detection protocol is executed for each of the physical links that form an aggregated link, and a notification is sent to a higher-level application (for example, a routing protocol), which is a requesting source of a communication line failure monitoring request, with a discrimination between a case in which the communication of the aggregated link in its entirety fails and a case in which some physical links of the aggregated link fail.
摘要:
Even when all of usable sessions are in use, a communication can be established for a new session and the interrupted session is automatically restored. Information on degrees of importance of communication sessions and information of restoration requirement are set in advance and stored in a session importance table in association with identifier (URI) of communication initiating terminals and identifier of destinations of communication. When a connection request for a session having a high degree of importance such as an emergency session is received, the session having the lowest degree of importance is selected and interrupted. Information of the interrupted session such as the communication initiator identifier and the communication destination identifier is stored in a session restoration table. The session is automatically restored as soon as a session resource becomes unoccupied according to the communication initiator identifier and the communication destination identifier stored in the session restoration table.
摘要:
Erroneous detection of a failure in spite of the absence of failure on the route on account of a communication delay is to be prevented. A node device detects a failure on the route to a remote node device is detected by a failure to receive a packet from the remote node device after the elapse of a determined detection time. The node device sets “remote system transmission interval x detection multiplier” to be a first detecting time on the basis of a packet transmission interval determined by negotiation with the remote node device. It also sets the sum of “remote system actual transmission interval x detection multiplier” and “tolerable delay time” to be a second detecting time. The first detecting time and the second detecting time are compared, and what is longer is determined as the detecting time to be applied to actual operation.
摘要:
Erroneous detection of a failure in spite of the absence of failure on the route on account of a communication delay is to be prevented. A node device detects a failure on the route to a remote node device is detected by a failure to receive a packet from the remote node device after the elapse of a determined detection time. The node device sets “remote system transmission interval×detection multiplier” to be a first detecting time on the basis of a packet transmission interval determined by negotiation with the remote node device. It also sets the sum of “remote system actual transmission interval ×detection multiplier” and “tolerable delay time” to be a second detecting time. The first detecting time and the second detecting time are compared, and what is longer is determined as the detecting time to be applied to actual operation.
摘要:
The present invention relates to a method for producing a modified foreign chromosome(s) or a fragment(s) thereof, which comprises the steps of: (a) preparing a microcell comprising a foreign chromosome(s) or a fragment(s) thereof, and transferring said foreign chromosome(s) or a fragment(s) into a cell with high homologous recombination efficiency through its fusion with said microcell; (b) in said cell with high homologous recombination efficiency, inserting a targeting vector by homologous recombination into a desired site of said foreign chromosome(s) or a fragment(s) thereof, and/or a desired site of a chromosome(s) derived from said cell with high homologous recombination efficiency, thereby marking said desired site; and (c) in said cell with high homologous recombination efficiency, causing deletion and/or translocation to occur at the marked site of said foreign chromosome(s) or a fragment(s) thereof.
摘要:
The specification relates to a method for producing a chimeric non-human animal, which comprises preparing a microcell containing a foreign chromosome(s) or a fragment(s) thereof and transferring the foreign chromosome(s) or fragment(s) thereof into a pluripotent cell by fusion with the microcell; a chimeric non-human animal which can be produced by the above method and its progeny; tissues and cells derived therefrom; and a method for using the same. Further, a pluripotent cell containing a foreign chromosome(s) or a fragment(s) thereof, a method for producing the same, and a method for using the same are also provided. Moreover, a pluripotent cell in which at least two endogenous genes are disrupted, and a method for producing the same by homologous recombination are provided.
摘要:
The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing an antibody λ light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the non-human animal or an offspring thereof; and a human antibody-producing mouse carrying the human artificial chromosome.
摘要:
The present invention relates to a method for producing a modified foreign chromosome(s) or a fragment(s) thereof, which comprises the steps of: (a) preparing a microcell comprising a foreign chromosome(s) or a fragment(s) thereof, and transferring said foreign chromosome(s) or a fragment(s) into a cell with high homologous recombination efficiency through its fusion with said microcell; (b) in said cell with high homologous recombination efficiency, inserting a targeting vector by homologous recombination into a desired site of said foreign chromosome(s) or a fragment(s) thereof, and/or a desired site of a chromosome(s) derived from said cell with high homologous recombination efficiency, thereby marking said desired site; and (c) in said cell with high homologous recombination efficiency, causing deletion and/or translocation to occur at the marked site of said foreign chromosome(s) or a fragment(s) thereof.
摘要:
The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing an antibody λ light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the nonhuman animal or an offspring thereof; and a human antibody-producing mouse carrying the human artificial chromosome.