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36 条记录 (耗时 0.03 秒)

    Rat CNP complementary DNA and precursor protein
    9.
    发明授权
    Rat CNP complementary DNA and precursor protein 失效
    大鼠CNP互补DNA和前体蛋白

    公开(公告)号：US5973134A

    公开(公告)日：1999-10-26

    申请号：US757606

    申请日：1991-09-11

    申请人： Hisayuki Matsuo ,  Masayasu Kojima ,  Kenji Kangawa ,  Naoto Minamito

    发明人： Hisayuki Matsuo ,  Masayasu Kojima ,  Kenji Kangawa ,  Naoto Minamito

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/22 ,  A61P7/10 ,  A61P9/12 ,  C07H21/04 ,  C07K14/00 ,  C07K14/575 ,  C07K14/58 ,  C12N15/12 ,  C12P21/02 ,  C07H17/00

    CPC分类号： C07K14/58 ,  A61K38/00

    摘要： A cDNA coding for a rat derived CNP (rCNP: C-type natriuretic pepteide), and a rat derived CNP precursor protein and derivatives thereof are disclosed.The rat derived CNP precursor is represented by the following amino acid sequence.Met His Leu Ser Gln Leu Ile Ala Cys Ala Leu Leu Leu Ala Leu Leu Ser Leu Arg Pro Ser Glu Ala Lys Pro Gly Thr Pro Pro Lys Val Pro Arg Thr Pro Pro Gly Glu Glu Leu Ala Glu Pro Gln Ala Ala Gly Gly Asn Gln Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg Leu Leu Arg Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu His Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly CysThe rCNP precursor and its derivatives are novel and have natriuretic and hypotensive activities.

    摘要翻译： 公开了编码大鼠衍生的CNP（rCNP：C型利尿钠蛋白酶）的cDNA和大鼠衍生的CNP前体蛋白及其衍生物。 大鼠衍生的CNP前体由以下氨基酸序列表示。 Met His Leu Ser Gln Leu Ile Ala Cys Ala Leu Leu Leu Ala Leu Leu Ser Leu Arg Pro Ser Glu Ala Lys Pro Gly Thr Pro Pro Lys Val Pro Arg Thr Pro Pro Gly Glu Glu Leu Ala Glu Pro Gln Ala Ala Gly Gly Asn Gln Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg Leu Leu Arg Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu His Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys rCNP前体及其衍生物是新颖的，具有钠尿和降血压活性。

    CNP analog peptides and their use
    10.
    发明授权
    CNP analog peptides and their use 失效
    CNP类似物及其用途

    公开(公告)号：US5434133A

    公开(公告)日：1995-07-18

    申请号：US828450

    申请日：1992-01-31

    申请人： Shoji Tanaka ,  Yoshiharu Minamitake ,  Yasuo Kitajima ,  Mayumi Furuya ,  Hisayuki Matsuo

    发明人： Shoji Tanaka ,  Yoshiharu Minamitake ,  Yasuo Kitajima ,  Mayumi Furuya ,  Hisayuki Matsuo

    IPC分类号： A61K38/22 ,  A61K38/00 ,  A61P43/00 ,  C07K7/08 ,  C07K14/575 ,  C07K14/58 ,  C12N15/16 ,  C07K14/00 ,  A61K38/16 ,  A61K38/17 ,  C07K14/435

    CPC分类号： C07K14/58 ,  A61K38/00 ,  Y02P20/55

    摘要： Novel peptides represented by the general formula: ##STR1## and physiologically acceptable acid addition salts thereof; where (A) represents H-, H-Gly, H-Lys-Gly, H-Ser-Lys-Gly, H-Leu-Ser-Lys-Gly, H-Gly-Leu-Ser-Lys-Gly, H-ser, H-Ser-Ser, H-Arg-Ser-Ser, H-Arg-Arg-Ser-Ser, H-Leu-Arg-Arg-Ser-Ser, H-Ser-Leu-Arg-Arg-Ser-Ser;(B) represents H-Cys or Pmp;(C) represents Phe-, pCl-Phe, pF-Phe, pNO.sub.2 -Phe or Cha;(D) represents Ile, Val, Aib, tLeu, Gly or Leu;(E) represents Lys or Arg;(F) represents Ile, Leu or Met;(G) represents Ser or Ala;(H) represents Met or Gln;(I) represents --OH, -Asn-OH, -Asn-Ser-OH, -Asn-Ser-Phe-OH, -Asn-Ser-Phe-Arg-OH or -Asn-Ser-Phe-Arg-Tyr-OH; and the symbol " . . . " represents a disulfide bond;provided that 1) .alpha.-hANP, 2) .alpha.-hANP (7-28) and 3) CNP-22 are excluded from the scope of that general formula.Also disclosed are agents for suppressing the growth of vascular smooth muscle cells that contains those peptides as effective ingredients.

    摘要翻译： 由通式表示的新肽：其加成盐; 其中（A）表示H，H-Gly，H-Lys-Gly，H-Ser-Lys-Gly，H-Leu-Ser-Lys-Gly，H-Gly-Leu-Ser-Lys-Gly， Ser，H-Ser-Ser，H-Arg-Ser-Ser，H-Arg-Arg-Ser-Ser，H-Leu-Arg-Arg-Ser-Ser，H-Ser-Leu-Arg-Arg- 塞尔 （B）代表H-Cys或Pmp; （C）表示Phe-，pCl-Phe，pF-Phe，pNO2-Phe或Cha; （D）代表Ile，Val，Aib，tLeu，Gly或Leu; （E）表示Lys或Arg; （F）表示Ile，Leu或Met; （G）表示Ser或Ala; （H）表示Met或Gln; （I）表示-OH，-Asn-OH，-Asn-Ser-OH，-Asn-Ser-Phe-OH，-Asn-Ser-Phe-Arg-OH或-Asn-Ser-Phe-Arg-Tyr- 哦; 符号“......”代表二硫键; 条件是1）α-hANP，2）α-hANP（7-28）和3）CNP-22被排除在该通式的范围之外。 还公开了抑制含有那些肽作为有效成分的血管平滑肌细胞生长的药剂。