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    METHOD FOR CHARACTERIZATION OF BIOLOGICAL BONDS
    1.
    发明申请
    METHOD FOR CHARACTERIZATION OF BIOLOGICAL BONDS 审中-公开
    生物学特征表征方法

    公开(公告)号：US20120184048A1

    公开(公告)日：2012-07-19

    申请号：US13498635

    申请日：2010-09-07

    申请人： Kim Van Ommering ,  Johannes Joseph Hubertina Barbara Schleipen ,  Jeroen Hans Nieuwenhuis

    发明人： Kim Van Ommering ,  Johannes Joseph Hubertina Barbara Schleipen ,  Jeroen Hans Nieuwenhuis

    IPC分类号： G01N21/49

    CPC分类号： G01N33/54373 ,  G01N21/552 ,  G01N33/54313

    摘要： The invention relates to the field of intensity measurements of a light scattering label bound to a surface of a support using an optical evanescent field. According to the invention, the method comprises the steps: a) Providing an assay comprising at least one light scattering label bound to a surface of a support by at least one bond; b) Measuring the fluctuations in the intensity of scattered light of the label in an optical evanescent field over time while the label is bound to the surface. The method according to the invention allows to identify different bonds and/or to distinguish between different bonds.

    摘要翻译： 本发明涉及使用光学渐逝场结合到支撑体表面的光散射标签的强度测量领域。 根据本发明，该方法包括以下步骤：a）提供包含至少一个光散射标记的测定结合至少一个键的支持物表面; b）当标签与表面结合时，测量随着时间的推移，光学衰减场中标签的散射光强度的波动。 根据本发明的方法允许识别不同的键和/或区分不同的键。

    Detection system and method
    2.
    发明授权
    Detection system and method 有权
    检测系统及方法

    公开(公告)号：US08618508B2

    公开(公告)日：2013-12-31

    申请号：US13119897

    申请日：2009-09-21

    申请人： Reinhold Wimberger-Friedl ,  Jeroen Hans Nieuwenhuis ,  Johannes Joseph Hubertina Barbara Schleipen

    发明人： Reinhold Wimberger-Friedl ,  Jeroen Hans Nieuwenhuis ,  Johannes Joseph Hubertina Barbara Schleipen

    IPC分类号： G01J1/42 ,  G01J1/58 ,  G21K5/00

    CPC分类号： G01N21/6428 ,  G01N21/648

    摘要： A detection system combining an excitation radiation source providing excitation radiation to an analysis region of a sample within a substrate having a detection surface, a detector for detecting radiation collected from the analysis region comprising the detection surface of the sample resulting from the excitation, and a magnet arrangement beneath the analysis region of the sample, and stationary with respect to the excitation radiation source and light coupling arrangement, for attracting magnetic beads within the sample to the substrate surface. The detection radiation is collected from the detection surface of the substrate to give an enhanced surface specificity.

    摘要翻译： 一种检测系统，其将激发辐射源组合到具有检测表面的基底内的样品的分析区域，用于检测从包括由激发产生的样品的检测表面的分析区域收集的辐射的检测器，以及 磁体布置在样品的分析区域下方，并且相对于激发辐射源和光耦合装置固定，用于将样品内的磁珠吸引到基底表面。 从衬底的检测表面收集检测辐射以提供增强的表面特异性。

    DETECTION SYSTEM AND METHOD
    3.
    发明申请
    DETECTION SYSTEM AND METHOD 有权
    检测系统和方法

    公开(公告)号：US20110168918A1

    公开(公告)日：2011-07-14

    申请号：US13119897

    申请日：2009-09-21

    申请人： Reinhold Wimberger-Friedl ,  Jeroen Hans Nieuwenhuis ,  Johannes Joseph Hubertina Barbara Schleipen

    发明人： Reinhold Wimberger-Friedl ,  Jeroen Hans Nieuwenhuis ,  Johannes Joseph Hubertina Barbara Schleipen

    IPC分类号： G01J1/58

    CPC分类号： G01N21/6428 ,  G01N21/648

    摘要： A detection system combines an excitation radiation source (18) providing excitation radiation (10) to an analysis region of a sample (14) within a substrate (16) having a detection surface, a detector (22) for detecting radiation collected from the analysis region comprising the detection surface of the sample resulting from the excitation, and a magnet arrangement (24) beneath the analysis region of the sample, and stationary with respect to the excitation radiation source and light coupling arrangement, for attracting magnetic beads (15) within the sample to the substrate surface The detection radiation is collected from the detection surface of the substrate, to give an enhanced surface specificity The invention combines the advantages of surface detection with a simple low cost magnetic system for bringing the target to the surface

    摘要翻译： 检测系统将提供激发辐射（10）的激发辐射源（18）组合到具有检测表面的衬底（16）内的样品（14）的分析区域，用于检测从分析中收集的辐射的检测器（22） 包括由激发产生的样品的检测表面的区域和在样品的分析区域下方的磁体布置（24），并且相对于激发辐射源和光耦合装置固定，用于吸引在其内部的磁珠（15） 样品到基板表面检测辐射是从基板的检测表面收集的，以提供更好的表面特性本发明将表面检测的优点与简单的低成本磁性系统相结合，使目标达到表面

    MEANS FOR THE SEPARATION OF MAGNETIC PARTICLES
    6.
    发明申请
    MEANS FOR THE SEPARATION OF MAGNETIC PARTICLES 审中-公开
    手段分离磁性颗粒

    公开(公告)号：US20100108578A1

    公开(公告)日：2010-05-06

    申请号：US12525833

    申请日：2008-01-31

    申请人： Wendy Uyen Dittmer ,  Jeroen Hans Nieuwenhuis ,  Peggy De Kievit ,  Kim Van Ommering

    发明人： Wendy Uyen Dittmer ,  Jeroen Hans Nieuwenhuis ,  Peggy De Kievit ,  Kim Van Ommering

    IPC分类号： B03C1/02

    CPC分类号： B03C1/288 ,  B03C1/32

    摘要： The invention relates to an apparatus (300) and a method for the separation of magnetic particles (1, 2) according to their properties, particularly their magnetic susceptibility. The apparatus comprises a magnetic field generator (320) with which magnetic actuation forces (Fm) can be exerted on the magnetic particles (1, 2) that affect a prevailing movement of the particles (1, 2), said movement being caused by non-magnetic influences, e.g. thermal energy or viscous drag (Fh). The magnetic field generator may for example comprise: (i) a wire (321) that crosses the flow of a sample fluid with varying inclination (α); (ii) wires that generate a local minimum of a magnetic potential from which different particles escape by Brownian motion with different rates; or (iii) pairs of particle-attracting wires for which the attraction of one wire is temporarily interrupted to allow the fastest magnetic particles to escape.

    摘要翻译： 本发明涉及一种根据其特性，特别是它们的磁化率分离磁性颗粒（1,2）的装置（300）和方法。 该装置包括磁场发生器（320），通过该磁场发生器可以对影响颗粒（1,2）主要运动的磁性颗粒（1,2）施加磁力驱动力（Fm），所述运动由非磁性元件 磁影响，例如 热能或粘滞阻力（Fh）。 磁场发生器可以例如包括：（i）穿过具有不同倾斜度（α）的样品流体的流动的导线（321）; （ii）产生局部最小磁场的导线，不同的粒子由不同速率的布朗运动逃离; 或（iii）一对引线，其中一根导线的吸引力暂时中断，以允许最快的磁性颗粒逸出。