公开(公告)号：US09864846B2

公开(公告)日：2018-01-09

申请号：US14018069

申请日：2013-09-04

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Charles Sugnet ,  Simon Cawley ,  Mohit Gupta ,  Iztok Marjanovic ,  Mark Beauchemin ,  Todd Rearick

IPC: G06F19/10 ,  G11C17/00 ,  H03M7/30 ,  G06F19/00

CPC classification number: G06F19/702 ,  G06F19/709 ,  H03M7/30

Abstract: A compression method includes: measuring a waveform associated with a chemical event occurring on a sensor array, wherein the waveform comprises a plurality of measured values and the chemical event is indicative of a number of nucleotide incorporations in a genetic sequencing reaction; applying a first compression process to the waveform, the first compression process including a truncating of data corresponding to a portion of the waveform that is not related to nucleotide incorporations in the genetic sequencing reaction; and applying a second compression process to the waveform, the second compression process including a data substitution process that replaces at least a portion of the waveform with a plurality of coefficients representative of the portion of the waveform.

公开(公告)号：US09515676B2

公开(公告)日：2016-12-06

申请号：US13754566

申请日：2013-01-30

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Charles Sugnet ,  Simon Cawley ,  Mohit Gupta ,  Iztok Marjanovic ,  Todd Rearick ,  Mark Beauchemin ,  Earl Hubbell

IPC: G06F19/24 ,  G11C17/00 ,  H03M7/30

CPC classification number: H03M7/30 ,  G06F19/24

Abstract: A compression method includes measuring a waveform associated with a chemical event occurring on a sensor array, wherein the waveform comprises at least one region associated with expected measured values and at least one region associated with unpredictable measured values; applying a first compression process to the waveform, the first compression process including an averaging of one or more frames in one or more portions of the waveform; and applying a second compression process to the waveform, the second compression process including a truncating of data corresponding to a portion of the waveform that is not related to a nucleotide incorporation component of the waveform.

Abstract translation: 压缩方法包括测量与传感器阵列上发生的化学事件相关联的波形，其中所述波形包括与预期测量值相关联的至少一个区域和与不可预测的测量值相关联的至少一个区域; 对所述波形应用第一压缩处理，所述第一压缩处理包括所述波形的一个或多个部分中的一个或多个帧的平均值; 以及对所述波形应用第二压缩处理，所述第二压缩处理包括对应于与所述波形的核苷酸掺入成分无关的所述波形的一部分的数据的截断。

公开(公告)号：US20140093881A1

公开(公告)日：2014-04-03

申请号：US14018069

申请日：2013-09-04

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Charles Sugnet ,  Simon Cawley ,  Mohit Gupta ,  Iztok Marjanovic

IPC: G06F19/00

CPC classification number: G06F19/702 ,  G06F19/709 ,  H03M7/30

Abstract: A compression method includes: measuring a waveform associated with a chemical event occurring on a sensor array, wherein the waveform comprises a plurality of measured values and the chemical event is indicative of a number of nucleotide incorporations in a genetic sequencing reaction; applying a first compression process to the waveform, the first compression process including a truncating of data corresponding to a portion of the waveform that is not related to nucleotide incorporations in the genetic sequencing reaction; and applying a second compression process to the waveform, the second compression process including a data substitution process that replaces at least a portion of the waveform with a plurality of coefficients representative of the portion of the waveform.

Abstract translation: 压缩方法包括：测量与传感器阵列上发生的化学事件相关联的波形，其中所述波形包括多个测量值，并且所述化学事件指示遗传测序反应中的核苷酸结合数量; 对波形应用第一压缩过程，第一压缩过程包括对应于与遗传测序反应中的核苷酸掺入无关的一部分波形的数据截断; 以及对所述波形应用第二压缩处理，所述第二压缩处理包括用代表所述波形部分的多个系数代替所述波形的至少一部分的数据替换处理。

公开(公告)号：US20170194985A1

公开(公告)日：2017-07-06

申请号：US15368765

申请日：2016-12-05

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Charles Sugnet ,  Simon CAWLEY ,  Mohit GUPTA ,  Iztok MARJANOVIC ,  Todd REARICK ,  Mark BEAUCHEMIN ,  Earl HUBBELL

IPC: H03M7/30 ,  G06F19/24

CPC classification number: H03M7/30 ,  G16B40/00

Abstract: A compression method includes measuring a waveform associated with a chemical event occurring on a sensor array, wherein the waveform comprises at least one region associated with expected measured values and at least one region associated with unpredictable measured values; applying a first compression process to the waveform, the first compression process including an averaging of one or more frames in one or more portions of the waveform; applying a keyframe delta compression to the frame-averaged data; forming a compressed data structure including a keyframe and calculated differences subsequent to the keyframe; and storing one or more compressed data structures in memory.