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    Method and Apparatus for Identifying Defects in a Chemical Sensor Array
    3.
    发明申请
    Method and Apparatus for Identifying Defects in a Chemical Sensor Array 有权
    用于识别化学传感器阵列缺陷的方法和装置

    公开(公告)号：US20130143221A1

    公开(公告)日：2013-06-06

    申请号：US13690959

    申请日：2012-11-30

    Applicant: Life Technologies Corporation

    Inventor： Mark Beauchemin

    IPC: G01N27/416

    CPC classification number: G01R31/2851 ,  G01N27/414 ,  G01N27/4145 ,  G01N27/416 ,  G01R31/2621

    Abstract: In one implementation, a method for operating an apparatus is described. The method includes applying a bias voltage to place a transistor of a reference sensor in a known state. The reference sensor is in an array of sensors that further includes a chemical sensor coupled to a reaction region for receiving at least one reactant. The method further includes acquiring an output signal from the reference sensor in response to the applied bias voltage. The method further includes determining a defect associated with the array if the output signal does not correspond to the known state.

    Abstract translation: 在一个实现中，描述了一种用于操作设备的方法。 该方法包括施加偏置电压以将参考传感器的晶体管置于已知状态。 参考传感器是传感器阵列，其还包括耦合到用于接收至少一种反应物的反应区域的化学传感器。 该方法还包括响应于施加的偏置电压从参考传感器获取输出信号。 该方法还包括如果输出信号不对应于已知状态，则确定与阵列相关联的缺陷。

    Methods and apparatus for measuring analytes
    4.
    发明授权
    Methods and apparatus for measuring analytes 有权

    公开(公告)号：US11768171B2

    公开(公告)日：2023-09-26

    申请号：US17063621

    申请日：2020-10-05

    Applicant: Life Technologies Corporation

    Inventor： Todd Rearick ,  Melville Davey ,  Mark Beauchemin

    IPC: G01N27/416 ,  G16B30/00 ,  G01N27/414

    CPC classification number: G01N27/4165 ,  G01N27/4145 ,  G16B30/00

    Abstract: A method, computer program product, and system are provided to calibrate a sensor array with a plurality of sensors. The method can include sweeping a voltage of a reference electrode from a first voltage to a second voltage, where the reference electrode is in fluid communication with the sensor array. The output voltage of each of the plurality of sensors can be monitored at one or more voltages within the first and second voltages. An overall average gain of the plurality of sensors can be calculated at each of the one or more voltages. Further, an acquisition window for the sensor array can be determined. The acquisition window can include a maximum distribution of sensors that provides a maximal overall average gain at a particular reference electrode voltage.

    Method and apparatus for identifying defects in a chemical sensor array
    5.
    发明授权
    Method and apparatus for identifying defects in a chemical sensor array 有权

    公开(公告)号：US10598723B2

    公开(公告)日：2020-03-24

    申请号：US14830559

    申请日：2015-08-19

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Mark Beauchemin

    IPC: G01R31/28 ,  G01N27/416 ,  G01R31/26 ,  G01N27/414

    Abstract: In one implementation, a method for operating an apparatus is described. The method includes applying a bias voltage to place a transistor of a reference sensor in a known state, the reference sensor in an array of sensors that further includes a chemical sensor coupled to a reaction region for receiving at least one reactant. The method further includes acquiring an output signal from the reference sensor in response to the applied bias voltage, and determining a defect associated with the array if the output signal does not correspond to the known state.

    SYSTEM AND METHOD FOR AUTOMATED REPEAT SEQUENCING
    7.
    发明公开
    SYSTEM AND METHOD FOR AUTOMATED REPEAT SEQUENCING 审中-公开

    公开(公告)号：US20240263168A1

    公开(公告)日：2024-08-08

    申请号：US18636580

    申请日：2024-04-16

    Applicant: Life Technologies Corporation

    Inventor： Chiu Tai Andrew Wong ,  Mark Beauchemin ,  Shanti Shankar ,  Kylan Szeto

    IPC: C12N15/10 ,  C12Q1/6825 ,  C12Q1/6874 ,  G01N35/10

    CPC classification number: C12N15/1065 ,  C12Q1/6825 ,  C12Q1/6874 ,  G01N35/1081

    Abstract: A method for sequencing a target polynucleotide includes detecting a first series of nucleotide incorporations complementary to at least a portion of the target polynucleotide. The first series of nucleotide incorporations forms a first complementary polynucleotide. The target nucleotide is secured to a substrate disposed in a sequencing zone of an assembly. The method further includes moving the substrate to which the target nucleotide is secured to a templating zone of the assembly; removing the first complementary polynucleotide when the substrate is disposed at the templating zone of the assembly, the target polynucleotide remaining secured to the substrate; following the removing, moving the substrate to which the target polynucleotide is secured to the sequencing zone; and detecting a second series of nucleotide incorporations complementary to at least a portion of the target polynucleotide, the second series of nucleotide incorporations forming a second complementary polynucleotide.

    System and method for automated repeat sequencing
    8.
    发明授权
    System and method for automated repeat sequencing 有权

    公开(公告)号：US11959074B2

    公开(公告)日：2024-04-16

    申请号：US17525737

    申请日：2021-11-12

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Chiu Tai Andrew Wong ,  Kylan Szeto ,  Shanti Shankar ,  Mark Beauchemin

    IPC: C12N15/10 ,  C12Q1/6825 ,  C12Q1/6874 ,  G01N35/10

    CPC classification number: C12N15/1065 ,  C12Q1/6825 ,  C12Q1/6874 ,  G01N35/1081

    Abstract: A method for sequencing a target polynucleotide includes detecting a first series of nucleotide incorporations complementary to at least a portion of the target polynucleotide. The first series of nucleotide incorporations forms a first complementary polynucleotide. The target nucleotide is secured to a substrate disposed in a sequencing zone of an assembly. The method further includes moving the substrate to which the target nucleotide is secured to a templating zone of the assembly; removing the first complementary polynucleotide when the substrate is disposed at the templating zone of the assembly, the target polynucleotide remaining secured to the substrate; following the removing, moving the substrate to which the target polynucleotide is secured to the sequencing zone; and detecting a second series of nucleotide incorporations complementary to at least a portion of the target polynucleotide, the second series of nucleotide incorporations forming a second complementary polynucleotide.

    Methods and apparatus for measuring analytes
    9.
    发明授权
    Methods and apparatus for measuring analytes 有权

    公开(公告)号：US10451585B2

    公开(公告)日：2019-10-22

    申请号：US14926264

    申请日：2015-10-29

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Todd Rearick ,  Mark Beauchemin

    IPC: G01N33/48 ,  G01N33/50 ,  G01N27/414 ,  G01N27/27 ,  C12Q1/6869 ,  G16B30/00

    Abstract: A method is provided to sample a sensor array. The method can include measuring a waveform associated with a chemical event occurring on the sensor array. The waveform can include at least one region associated with expected measured values and at least one region associated with unpredictable measured values. The method can also include applying a first frame averaging to the at least one region associated with the expected measured values. Here, a first number of frames can be included in the first frame averaging. Further, the method can include applying a second frame averaging to the at least one region associated with the unpredictable measured values, where a second number of frames can be included in the second frame averaging. The second number of frames can be less than the first number of frames.

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