中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

13 records (took 0.022 seconds)

    Methods and computer program products for compression of sequencing data
    1.
    发明授权
    Methods and computer program products for compression of sequencing data 有权
    用于压缩测序数据的方法和计算机程序产品

    公开(公告)号：US09515676B2

    公开(公告)日：2016-12-06

    申请号：US13754566

    申请日：2013-01-30

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Charles Sugnet ,  Simon Cawley ,  Mohit Gupta ,  Iztok Marjanovic ,  Todd Rearick ,  Mark Beauchemin ,  Earl Hubbell

    IPC: G06F19/24 ,  G11C17/00 ,  H03M7/30

    CPC classification number: H03M7/30 ,  G06F19/24

    Abstract: A compression method includes measuring a waveform associated with a chemical event occurring on a sensor array, wherein the waveform comprises at least one region associated with expected measured values and at least one region associated with unpredictable measured values; applying a first compression process to the waveform, the first compression process including an averaging of one or more frames in one or more portions of the waveform; and applying a second compression process to the waveform, the second compression process including a truncating of data corresponding to a portion of the waveform that is not related to a nucleotide incorporation component of the waveform.

    Abstract translation: 压缩方法包括测量与传感器阵列上发生的化学事件相关联的波形，其中所述波形包括与预期测量值相关联的至少一个区域和与不可预测的测量值相关联的至少一个区域; 对所述波形应用第一压缩处理，所述第一压缩处理包括所述波形的一个或多个部分中的一个或多个帧的平均值; 以及对所述波形应用第二压缩处理，所述第二压缩处理包括对应于与所述波形的核苷酸掺入成分无关的所述波形的一部分的数据的截断。

    METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR MAKING BASE CALLS IN NUCLEIC ACID SEQUENCING
    7.
    发明申请
    METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR MAKING BASE CALLS IN NUCLEIC ACID SEQUENCING 审中-公开

    公开(公告)号：US20190170680A1

    公开(公告)日：2019-06-06

    申请号：US16196502

    申请日：2018-11-20

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Marcin Sikora ,  Melville Davey ,  Christian Koller ,  Simon Cawley ,  Alan Williams ,  David Kulp

    IPC: G01N27/414 ,  G16B30/00

    Abstract: A method for nucleic acid sequencing includes receiving a plurality of observed or measured signals indicative of a parameter observed or measured for a plurality of defined spaces; determining, for at least some of the defined spaces, whether the defined space comprises one or more sample nucleic acids; processing, for at least some of the defined spaces, the observed or measured signal to improve a quality of the observed or measured signal; generating, for at least some of the defined spaces, a set of candidate sequences of bases for the defined space using one or more metrics adapted to associate a score or penalty to the candidate sequences of bases; and selecting the candidate sequence leading to a highest score or a lowest penalty as corresponding to the correct sequence for the one or more sample nucleic acids in the defined space.

    METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR NUCLEIC ACID SEQUENCING
    10.
    发明申请
    METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR NUCLEIC ACID SEQUENCING 有权

    公开(公告)号：US20220283117A1

    公开(公告)日：2022-09-08

    申请号：US17650941

    申请日：2022-02-14

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Melville Davey ,  Simon Cawley ,  Alan Williams

    IPC: G01N27/414 ,  G16B30/00 ,  G16B30/10 ,  G16B30/20

    Abstract: A method for nucleic acid sequencing includes receiving a plurality of signals indicative of a parameter measured for a plurality of defined spaces, at least some of the defined spaces including one or more sample nucleic acids, the signals being responsive to a plurality of nucleotide flows introducing nucleotides to the defined spaces; determining, for at least some of the defined spaces, whether the defined space includes a sample nucleic acid; processing, for at least some of the defined spaces determined to include a sample nucleic acid, the received signals to improve a quality of the received signals; and predicting a plurality of nucleotide sequences corresponding to respective sample nucleic acids for the defined spaces based on the processed signals and the nucleotide flows.

Patent Agency Ranking