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    Methods and apparatus for measuring analytes
    2.
    发明授权
    Methods and apparatus for measuring analytes 有权

    公开(公告)号：US11768171B2

    公开(公告)日：2023-09-26

    申请号：US17063621

    申请日：2020-10-05

    Applicant: Life Technologies Corporation

    Inventor： Todd Rearick ,  Melville Davey ,  Mark Beauchemin

    IPC: G01N27/416 ,  G16B30/00 ,  G01N27/414

    CPC classification number: G01N27/4165 ,  G01N27/4145 ,  G16B30/00

    Abstract: A method, computer program product, and system are provided to calibrate a sensor array with a plurality of sensors. The method can include sweeping a voltage of a reference electrode from a first voltage to a second voltage, where the reference electrode is in fluid communication with the sensor array. The output voltage of each of the plurality of sensors can be monitored at one or more voltages within the first and second voltages. An overall average gain of the plurality of sensors can be calculated at each of the one or more voltages. Further, an acquisition window for the sensor array can be determined. The acquisition window can include a maximum distribution of sensors that provides a maximal overall average gain at a particular reference electrode voltage.

    Models for analyzing data from sequencing-by-synthesis operations
    3.
    发明授权
    Models for analyzing data from sequencing-by-synthesis operations 有权

    公开(公告)号：US11657893B2

    公开(公告)日：2023-05-23

    申请号：US15929565

    申请日：2020-05-11

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Todd Rearick

    IPC: G01N33/48 ,  G01N33/50 ,  G16B5/00 ,  C12Q1/6874 ,  G16B25/00 ,  G16B30/00

    CPC classification number: G16B5/00 ,  C12Q1/6874 ,  G16B25/00 ,  G16B30/00 ,  C12Q1/6874 ,  C12Q2537/165 ,  C12Q2563/113 ,  C12Q2563/116

    Abstract: A method of modeling a background signal when sequencing a polynucleotide strand using sequencing-by-synthesis includes: flowing a series of nucleotide flows onto a reactor array having multiple reaction confinement regions, one or more copies of the polynucleotide strand being located in a loaded reaction confinement region of the reactor array, the loaded reaction confinement region being located in a vicinity of one or more neighboring reaction confinement regions that may or may not be loaded; receiving output signals from the reactor array; and modeling a background signal for the loaded reaction confinement region using the received output signals and a model adapted to account at least for an exchange of ions between the one or more neighboring reaction confinement regions and a headspace adjacent the loaded reaction confinement region and the one or more neighboring reaction confinement regions.

    MODELS FOR ANALYZING DATA FROM SEQUENCING-BY-SYNTHESIS OPERATIONS
    4.
    发明申请
    MODELS FOR ANALYZING DATA FROM SEQUENCING-BY-SYNTHESIS OPERATIONS 审中-公开

    公开(公告)号：US20200342952A1

    公开(公告)日：2020-10-29

    申请号：US15929565

    申请日：2020-05-11

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Todd Rearick

    IPC: G16B5/00 ,  C12Q1/6874 ,  G16B25/00 ,  G16B30/00

    Abstract: A method of modeling a background signal when sequencing a polynucleotide strand using sequencing-by-synthesis includes: flowing a series of nucleotide flows onto a reactor array having multiple reaction confinement regions, one or more copies of the polynucleotide strand being located in a loaded reaction confinement region of the reactor array, the loaded reaction confinement region being located in a vicinity of one or more neighboring reaction confinement regions that may or may not be loaded; receiving output signals from the reactor array; and modeling a background signal for the loaded reaction confinement region using the received output signals and a model adapted to account at least for an exchange of ions between the one or more neighboring reaction confinement regions and a headspace adjacent the loaded reaction confinement region and the one or more neighboring reaction confinement regions.

    Windowed sequencing
    5.
    发明授权
    Windowed sequencing 有权

    公开(公告)号：US10100357B2

    公开(公告)日：2018-10-16

    申请号：US15043296

    申请日：2016-02-12

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Todd Rearick ,  Mark James Milgrew ,  Jonathan Schultz ,  Chris Papalias ,  Kim L. Johnson

    IPC: C12Q1/68 ,  G06F19/22 ,  C12Q1/6874

    Abstract: In one implementation, a method is described. The method includes determining an operational characteristic of sensors of a sensor array. The method further includes selecting a group of sensors in the array based on the operational characteristic of sensors in the group. The method further includes enabling readout of the sensors in the selected group. The method further includes receiving output signals from the enabled sensors, the output signals indicating chemical reactions occurring proximate to the sensors of the sensor array.

    Apparatuses, methods, systems, and computer-readable media for fluid potential artifact correction in reagent delivery systems
    7.
    发明授权
    Apparatuses, methods, systems, and computer-readable media for fluid potential artifact correction in reagent delivery systems 有权

    公开(公告)号：US12050196B2

    公开(公告)日：2024-07-30

    申请号：US17499676

    申请日：2021-10-12

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Chiu Tai Andrew Wong ,  Todd Rearick ,  John Donohue

    IPC: G01N27/414 ,  G16B30/00

    CPC classification number: G01N27/4145 ,  G16B30/00

    Abstract: A method for correcting nucleotide incorporation signals for fluid potential effects or disturbances arising in nucleic acid sequencing-by-synthesis includes: disposing a plurality of template polynucleotide strands in a plurality of defined spaces disposed on a sensor array, the template polynucleotide strands having a sequencing primer and a polymerase bound therewith; exposing the template polynucleotide strands to a series of flows of nucleotide species flowed through a fluid manifold, the fluid manifold comprising passages for flowing nucleotide species and a branch passage for flowing a solution, the branch passage comprising a reference electrode and a sensing electrode; obtaining a plurality of nucleotide incorporation signals corresponding to the plurality of defined spaces, the nucleotide incorporation signals having a signal intensity related to a number of nucleotide incorporations; and correcting at least some of the plurality of nucleotide incorporation signals for fluid potential effects or disturbances.

    Methods and apparatus for measuring analytes
    9.
    发明授权
    Methods and apparatus for measuring analytes 有权

    公开(公告)号：US10809226B2

    公开(公告)日：2020-10-20

    申请号：US15920387

    申请日：2018-03-13

    Applicant: Life Technologies Corporation

    Inventor： Todd Rearick ,  Melville Davey ,  Mark Beauchemin

    IPC: G01N27/416 ,  G16B30/00 ,  G01N27/414

    Abstract: A method, computer program product, and system are provided to calibrate a sensor array with a plurality of sensors. The method can include sweeping a voltage of a reference electrode from a first voltage to a second voltage, where the reference electrode is in fluid communication with the sensor array. The output voltage of each of the plurality of sensors can be monitored at one or more voltages within the first and second voltages. An overall average gain of the plurality of sensors can be calculated at each of the one or more voltages. Further, an acquisition window for the sensor array can be determined. The acquisition window can include a maximum distribution of sensors that provides a maximal overall average gain at a particular reference electrode voltage.

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