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    WINDOWED SEQUENCING
    1.
    发明申请
    WINDOWED SEQUENCING 审中-公开

    公开(公告)号：US20190106745A1

    公开(公告)日：2019-04-11

    申请号：US16153898

    申请日：2018-10-08

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Todd Rearick ,  Mark MILGREW ,  Jonathan SCHULTZ ,  Chris PAPALIAS ,  Kim JOHNSON

    IPC: C12Q1/6874 ,  G06F19/22

    Abstract: In one implementation, a method is described. The method includes determining an operational characteristic of sensors of a sensor array. The method further includes selecting a group of sensors in the array based on the operational characteristic of sensors in the group. The method further includes enabling readout of the sensors in the selected group. The method further includes receiving output signals from the enabled sensors, the output signals indicating chemical reactions occurring proximate to the sensors of the sensor array.

    METHODS AND APPARATUS FOR TESTING ISFET ARRAYS
    2.
    发明申请
    METHODS AND APPARATUS FOR TESTING ISFET ARRAYS 审中-公开

    公开(公告)号：US20190033363A1

    公开(公告)日：2019-01-31

    申请号：US15979439

    申请日：2018-05-14

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Jarie BOLANDER ,  Keith FIFE ,  Mark MILGREW

    IPC: G01R31/26 ,  G01R31/28 ,  G01N27/414

    Abstract: The invention provides testing of a chemically-sensitive transistor device, such as an ISFET device, without exposing the device to liquids. In one embodiment, the invention performs a first test to calculate a resistance of the transistor. Based on the resistance, the invention performs a second test to transition the testing transistor among a plurality of modes. Based on corresponding measurements, a floating gate voltage is then calculated with little or no circuitry overhead. In another embodiment, the parasitic capacitance of at least either the source or drain is used to bias the floating gate of an ISFET. A driving voltage and biasing current are applied to exploit the parasitic capacitance to test the functionality of the transistor.

    WINDOWED SEQUENCING
    4.
    发明申请
    WINDOWED SEQUENCING 审中-公开

    公开(公告)号：US20200332358A1

    公开(公告)日：2020-10-22

    申请号：US16866653

    申请日：2020-05-05

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Todd Rearick ,  Mark MILGREW ,  Jonathan SCHULTZ ,  Chris PAPALIAS ,  Kim JOHNSON

    IPC: C12Q1/6874 ,  G16B30/00

    Abstract: In one implementation, a method is described. The method includes determining an operational characteristic of sensors of a sensor array. The method further includes selecting a group of sensors in the array based on the operational characteristic of sensors in the group. The method further includes enabling readout of the sensors in the selected group. The method further includes receiving output signals from the enabled sensors.

    MICROWELL STRUCTURES FOR CHEMICALLY-SENSITIVE SENSOR ARRAYS
    6.
    发明申请
    MICROWELL STRUCTURES FOR CHEMICALLY-SENSITIVE SENSOR ARRAYS 审中-公开
    用于化学敏感传感器阵列的MICROWELL结构

    公开(公告)号：US20130071915A1

    公开(公告)日：2013-03-21

    申请号：US13675400

    申请日：2012-11-13

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： James BUSTILLO ,  Mark MILGREW

    IPC: C12Q1/68

    CPC classification number: G01N27/4145 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N27/27 ,  G01N27/414 ,  Y10T29/49002

    Abstract: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

    Abstract translation: 与用于监测化学和/或生物反应的FET阵列相关的方法和装置，例如核酸序列合成反应。 本文提供的一些方法涉及在核酸测序反应期间从释放的氢离子改进信号（以及信噪比）。

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