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1.发明授权公开(公告)号：US06440657B1
公开(公告)日：2002-08-27
申请号：US09478492
申请日：2000-01-06
申请人： Luc Montangnier , Bernard Krust , Solange Chamaret , François Clavel , Jean-Claude Chermann , Françoise Barre-Sinoussi , Marc Alizon , Pierre Sonigo , Stewart Cole , Olivier Danos , Simon Wain-Hobson
发明人： Luc Montangnier , Bernard Krust , Solange Chamaret , François Clavel , Jean-Claude Chermann , Françoise Barre-Sinoussi , Marc Alizon , Pierre Sonigo , Stewart Cole , Olivier Danos , Simon Wain-Hobson
IPC分类号： C12Q170
CPC分类号： C07K14/005 , C12N2740/16122 , C12N2740/16222 , C12Q1/703
摘要： The molecular cloning and characterization of a novel human retrovirus, designated lymphadenopathy-associated virus, or LAV, is disclosed. LAV was originally isolated from a patient with acquired immune deficiency syndrome (AIDS). A cloned LAV complementary DNA (cDNA) was used to screen a library of recombinant phages constructed from the genomic DNA of LAV-infected T lymphocytes. The nucleotide sequence of an insert obtained from the recombinant phage clone &lgr;J19 was ascertained through M13 shotgun cloning and the dideoxy chain termination sequencing method. The env coding region was identified and various hydrophilic peptides obtained therefrom. These peptides correspond to amino acids 551-577, 594-603, 621-630, 657-679, and 719-758 of the LAV envelope glycoprotein. These peptides should provide suitable diagnostic reagents for the detection LAV-specific antibodies and for the generation of LAV-specific immunological reagents.
摘要翻译： 公开了一种新型人类逆转录病毒（称为淋巴结病相关病毒）或LAV的分子克隆和表征。 LAV最初与获得性免疫缺陷综合征（AIDS）的患者分离。 使用克隆的LAV互补DNA（cDNA）筛选由LAV感染的T淋巴细胞的基因组DNA构建的重组噬菌体文库。 通过M13霰弹枪克隆和双脱氧链终止测序方法确定从重组噬菌体克隆lambdJ19获得的插入物的核苷酸序列。 鉴定了env编码区，并由其获得各种亲水性肽。 这些肽对应于LAV包膜糖蛋白的氨基酸551-577,594-603,621-630,657-679和719-758。 这些肽应为检测LAV特异性抗体和产生LAV特异性免疫试剂提供合适的诊断试剂。
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2.发明授权Nucleic acids and pepties of human immunodeficiency virus type-1 (HIV-1). 失效人类免疫缺陷病毒1型（HIV-1）的核酸和肽。
公开(公告)号：US5843638A
公开(公告)日：1998-12-01
申请号：US468387
申请日：1995-06-06
申请人： Luc Montagnier , Bernard Krust , Solange Chamaret , Fran.cedilla.ois Clavel , Jean-Claude Chermann , Fran.cedilla.oise Barre-Sinoussi , Marc Alizon , Pierre Sonigo , Stewart Cole , Olivier Danos , Simon Wain-Hobson
发明人： Luc Montagnier , Bernard Krust , Solange Chamaret , Fran.cedilla.ois Clavel , Jean-Claude Chermann , Fran.cedilla.oise Barre-Sinoussi , Marc Alizon , Pierre Sonigo , Stewart Cole , Olivier Danos , Simon Wain-Hobson
CPC分类号： C07K14/005 , C12Q1/703 , C12N2740/16122 , C12N2740/16222
摘要： This invention is directed to nucleic acids derived from the pol region of the genome of human immunodeficiency virus type 1 (HIV-1). The nucleic acids are useful as probes for the detection of HIV-1. More particularly, this invention is directed to nucleic acids encoding a pol region of HIV-1 extending from about nucleotide 1856 to about 1906 and extending from about nucleotide 2048 to about nucleotide 2797.
摘要翻译： 本发明涉及从人类免疫缺陷病毒1型（HIV-1）的基因组的pol区衍生的核酸。 核酸可用作检测HIV-1的探针。 更具体地，本发明涉及编码HIV-1的pol区的核酸，其延伸自约核苷酸1856至约1906并从约核苷酸2048延伸至约核苷酸2797。
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3.发明授权Cloned DNA sequences hybridizable with genomic RNA of lymphadenopathy associated virus (LAV) 失效与淋巴结病相关病毒（LAV）的基因组RNA杂交的克隆DNA序列公开(公告)号：US08329396B1
公开(公告)日：2012-12-11
申请号：US08052728
申请日：1993-04-27
申请人： Marc Alizon , Francoise Barre Sinoussi , Pierre Sonigo , Pierre Tiollais , Jean-Claude Chermann , Luc Montagnier , Simon Wain-Hobson
发明人： Marc Alizon , Francoise Barre Sinoussi , Pierre Sonigo , Pierre Tiollais , Jean-Claude Chermann , Luc Montagnier , Simon Wain-Hobson
CPC分类号： C07K14/005 , C12N2740/16022 , C12Q1/703
摘要： This invention is in the field of lymphadenopathy virus. This invention relates to a diagnostic means and method of detecting lymphadenopathy associated virus or related viruses or DNA pro-viruses with cloned DNA sequences which are hybridizable to genomic RNA and DNA of lymphadenopathy associated virus. It further relates to the cloned DNA sequences and a process for their preparation.
摘要翻译： 本发明在淋巴结病毒病毒领域。 本发明涉及用克隆的DNA序列检测淋巴结病毒相关病毒或相关病毒或DNA前病毒的诊断方法和方法，其可与基因组RNA和淋巴结病病毒相关病毒的DNA杂交。 它还涉及克隆的DNA序列及其制备方法。
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公开(公告)号：US07626013B1
公开(公告)日：2009-12-01
申请号：US08466921
申请日：1995-06-06
申请人： Marc Alizon , Francoise Barre Sinoussi , Pierre Sonigo , Pierre Tiollais , Jean-Claude Chermann , Luc Montagnier , Simon Wain-Hobson
发明人： Marc Alizon , Francoise Barre Sinoussi , Pierre Sonigo , Pierre Tiollais , Jean-Claude Chermann , Luc Montagnier , Simon Wain-Hobson
CPC分类号： C07K14/005 , C12N2740/16022 , C12Q1/703
摘要： The inventors have isolated cloned cDNA encoding the RNA genome of Human Immunodeficiency Virus type 1 (HIV-1). Various clones are described, which encode different regions of the genome, including those regions encoding viral antigens or proteins. Hybridization results indicate the difference between the HIV-1 clones and those of HTLV-I and HTLV-II. The inventors have also produced a restriction map of the entire cloned genomic sequence in order to facilitate further subcloning and using the restriction fragments in other hybridization tests and in methods to express encoded sequences.
摘要翻译： 发明人分离了编码人类免疫缺陷病毒1型（HIV-1）的RNA基因组的克隆cDNA。 描述了编码基因组的不同区域的各种克隆，包括编码病毒抗原或蛋白质的那些区域。 杂交结果表明HIV-1克隆与HTLV-I和HTLV-II的克隆之间的差异。 本发明人还制备了克隆的整个克隆基因组序列的限制图谱，以促进进一步的亚克隆，并在其它杂交试验和表达编码序列的方法中使用限制性片段。
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5.发明授权Nucleic acid probe of human immunodeficiency virus type 1 (HIV-1), and a method and kit employing this probe for detecting the presence of nucleic acid of HIV-1 失效人类免疫缺陷病毒1型（HIV-1）的核酸探针，以及采用该探针检测HIV-1核酸存在的方法和试剂盒公开(公告)号：US08507196B1
公开(公告)日：2013-08-13
申请号：US08051226
申请日：1993-04-23
申请人： Marc Alizon , Francoise Barre Sinoussi , Pierre Sonigo , Pierre Tiollais , Jean-Claude Chermann , Luc Montagnier , Simon Wain-Hobson
发明人： Marc Alizon , Francoise Barre Sinoussi , Pierre Sonigo , Pierre Tiollais , Jean-Claude Chermann , Luc Montagnier , Simon Wain-Hobson
IPC分类号： C07H21/02
CPC分类号： C07K14/005 , C12N2740/16022 , C12Q1/703
摘要： This invention is in the field of lymphadenopathy virus. This invention relates to a diagnostic means and method to detect the presence of DNA, RNA, or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates to the DNA fragments, vectors comprising them, and the proteins expressed.
摘要翻译： 本发明在淋巴结病毒病毒领域。 本发明涉及通过使用DNA片段或由所述DNA片段编码的肽来检测与所获得的免疫缺陷综合征或淋巴结病综合征相关的淋巴结病变逆转录病毒的DNA，RNA或抗体的存在的诊断方法和方法 。 本发明还涉及DNA片段，包含它们的载体和表达的蛋白质。
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6.发明授权Method for detecting human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) activity 失效检测人类免疫缺陷病毒1型（HIV-1）逆转录酶（RT）活性的方法公开(公告)号：US07585619B1
公开(公告)日：2009-09-08
申请号：US08384248
申请日：1995-02-06
申请人： Marc Alizon , Francoise Barre Sinoussi , Pierre Sonigo , Pierre Tiollais , Jean-Claude Chermann , Luc Montagnier , Simon Wain-Hobson
发明人： Marc Alizon , Francoise Barre Sinoussi , Pierre Sonigo , Pierre Tiollais , Jean-Claude Chermann , Luc Montagnier , Simon Wain-Hobson
CPC分类号： C07K14/005 , C12N2740/16022 , C12Q1/703
摘要： This invention is in the field of lymphadenopathy virus. This invention relates to a diagnostic means and method of detecting lymphadenopathy associated virus or related viruses or DNA pro-viruses with cloned DNA sequences which are hybridizable to genomic RNA and DNA of lymphadenopathy associated virus. It further relates to the cloned DNA sequences and a process for their preparation.
摘要翻译： 本发明在淋巴结病毒病毒领域。 本发明涉及用克隆的DNA序列检测淋巴结病毒相关病毒或相关病毒或DNA前病毒的诊断方法和方法，其可与基因组RNA和淋巴结病病毒相关病毒的DNA杂交。 它还涉及克隆的DNA序列及其制备方法。
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公开(公告)号：US07341731B2
公开(公告)日：2008-03-11
申请号：US10180460
申请日：2002-06-27
申请人： Luc Montagnier , Solange Chamaret , Denise Guetard , Marc Alizon , François Clavel , Mireille Guyader , Pierre Sonigo , Françoise Brun-Vezinet , Marianne Rey , Christine Rouzioux , Christine Katlama
发明人： Luc Montagnier , Solange Chamaret , Denise Guetard , Marc Alizon , François Clavel , Mireille Guyader , Pierre Sonigo , Françoise Brun-Vezinet , Marianne Rey , Christine Rouzioux , Christine Katlama
IPC分类号： A61K39/21
CPC分类号： C07K7/06 , A61K38/00 , A61K39/00 , C07K14/005 , C12N7/00 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , C12Q1/703 , G01N33/56988 , G01N2333/162 , G01N2469/20
摘要： The invention relates to a composition comprising at least one antigen, wherein the antigen is a protein or glycoprotein of a HIV-2 virus, wherein the HIV-2 virus has infectious properties with respect to human T4 lymphocytes and the essential morphological or immunological property of at least one of the retroviruses deposited at the CNCM under No. I-502, I-532, I-642, and I-643. It also relates to a process for the production of HIV-2 retrovirus antigens by lysing cells infected with the virus or lysing purified virus and recovering the antigens.
摘要翻译： 本发明涉及包含至少一种抗原的组合物，其中所述抗原是HIV-2病毒的蛋白质或糖蛋白，其中所述HIV-2病毒相对于人T4淋巴细胞具有感染性质，以及所述HIV-2病毒的基本形态学或免疫学性质 至少有一种在CNCM下存放在I-502，I-532，I-642和I-643下的逆转录病毒。 它还涉及通过裂解感染病毒的细胞或裂解纯化的病毒并回收抗原来生产HIV-2逆转录病毒抗原的方法。
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8.发明授权In vitro diagnostic methods and kits for the detection of HIV-2-specific antibodies 失效用于检测HIV-2特异性抗体的体外诊断方法和试剂盒公开(公告)号：US06265149B1
公开(公告)日：2001-07-24
申请号：US08470491
申请日：1995-06-06
申请人： Luc Montagnier , Solange Chamaret , Denise Guetard , Marc Alizon , François Clavel , Mireille Guyader , Pierre Sonigo , Françoise Brun-Vezinet , Marianne Rey , Christine Rouzioux , Christine Katlama
发明人： Luc Montagnier , Solange Chamaret , Denise Guetard , Marc Alizon , François Clavel , Mireille Guyader , Pierre Sonigo , Françoise Brun-Vezinet , Marianne Rey , Christine Rouzioux , Christine Katlama
IPC分类号： C12Q170
CPC分类号： C07K7/06 , A61K38/00 , A61K39/00 , C07K14/005 , C12N7/00 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , C12Q1/703 , G01N33/56988 , G01N2333/162 , G01N2469/20
摘要： The claimed invention is directed toward in vitro methods for the detection of human immunodeficiency virus type 2 (HIV-2) antibodies employing polypeptide fragments of HIV-2 Gag.
摘要翻译： 所要求保护的发明涉及使用HIV-2Gag的多肽片段检测使用HIV-2抗体的人类免疫缺陷病毒的体外方法。
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9.发明授权Retrovirus capable of causing AIDS, means and methods for detecting it in vitro 失效能够引起艾滋病的逆转录病毒，体外检测方法和方法公开(公告)号：US07115363B1
公开(公告)日：2006-10-03
申请号：US08470489
申请日：1995-06-06
申请人： Luc Montagnier , Solange Chamaret , Denise Guetard , Marc Alizon , François Clavel , Mireille Guyader , Pierre Sonigo , Francoise Brun-Vezinet , Marianne Rey , Christine Rouzioux , Christine Katlama
发明人： Luc Montagnier , Solange Chamaret , Denise Guetard , Marc Alizon , François Clavel , Mireille Guyader , Pierre Sonigo , Francoise Brun-Vezinet , Marianne Rey , Christine Rouzioux , Christine Katlama
IPC分类号： C12Q1/70
CPC分类号： C07K7/06 , A61K38/00 , A61K39/00 , C07K14/005 , C12N7/00 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , C12Q1/703 , G01N33/56988 , G01N2333/162 , G01N2469/20
摘要： The invention relates to a new class of retroviruses, designated by HIV-2, of which samples have been deposited to the ECACC under numbers 87.01.1001 and 87.01.1002 and to the NCIB under numbers 12.398 and 12.399.It relates also to antigens capable to be obtained from this virus, particularly proteins p12, p16, p26 and gp140. These various antigens can be used for the diagnosis of the disease, especially by contacting these antigens with a serum of a patient submitted to the diagnosis.It relates to immunogenic compositions containing more particularly the glycoprotein gp140. Finally it concerns nucleotidic sequences, which can be used especially as hybridization probes, derived from the RNA of HIV-2.
摘要翻译： 本发明涉及由HIV-2指定的一类新的逆转录病毒，其中样品已经按照号码87.01.1001和87.01.1002保藏在ECACC，编号为12.398和12.399的NCIB。 它还涉及能够从该病毒获得的抗原，特别是蛋白质p12，p16，p26和gp140。 这些各种抗原可以用于疾病的诊断，特别是通过将这些抗原与患者的血清接触进行诊断。 本发明涉及更具体地包含糖蛋白gp140的免疫原性组合物。 最后，它涉及核苷酸序列，其可以特别用作衍生自HIV-2的RNA的杂交探针。
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公开(公告)号：US06664041B2
公开(公告)日：2003-12-16
申请号：US09862511
申请日：2001-05-23
申请人： Luc Montagnier , Solange Chamaret , Denise Guetard , Marc Alizon , François Clavel , Mireille Guyader , Pierre Sonigo , Françoise Brun-Vezinet , Marianne Rey , Christine Rouzioux , Christine Katlama
发明人： Luc Montagnier , Solange Chamaret , Denise Guetard , Marc Alizon , François Clavel , Mireille Guyader , Pierre Sonigo , Françoise Brun-Vezinet , Marianne Rey , Christine Rouzioux , Christine Katlama
IPC分类号： C12Q170
CPC分类号： C07K7/06 , A61K38/00 , A61K39/00 , C07K14/005 , C12N7/00 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , C12Q1/703 , G01N33/56988 , G01N2333/162 , G01N2469/20
摘要： The invention relates to a new class of retroviruses, designated by HIV-2, of which samples have been deposited to the ECACC under numbers 87.01.1001 and 87.01.1002 and to the NCIB under numbers 12.398 and 12.399. It relates also to antigens capable to be obtained from this virus, particularly proteins p12, p16, p26 and gp140. These various antigens can be used for the diagnosis of the disease, especially by contacting these antigens with a serum of a patient submitted to the diagnosis. It relates to immunogenic compositions containing more particularly the glycoprotein gp140. Finally it concerns nucleotidic sequences, which can be used especially as hybridization probes, derived from the RNA of HIV-2.
摘要翻译： 本发明涉及由HIV-2指定的一类新的逆转录病毒，其中样品已经以数字87.01.1001和87.01.1002保藏在ECACC中，并且编号为12.398和12.399的NCIB。还涉及抗原能力 从该病毒获得，特别是蛋白质p12，p16，p26和gp140。 这些各种抗原可以用于疾病的诊断，特别是通过使这些抗原与患者的血清接触进行诊断。其涉及包含更特别是糖蛋白gp140的免疫原性组合物。 最后，它涉及核苷酸序列，其可以特别用作衍生自HIV-2的RNA的杂交探针。
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