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公开(公告)号：US20080312146A1
公开(公告)日：2008-12-18
申请号：US11751261
申请日：2007-05-21
申请人： Luisa Iruela-Arispe , Gregg A. Hastings , Steven M. Ruben , Zdenka L. Jonak , Stephen H. Trulli , James A. Fornwald , Jonathan A. Terrett
发明人： Luisa Iruela-Arispe , Gregg A. Hastings , Steven M. Ruben , Zdenka L. Jonak , Stephen H. Trulli , James A. Fornwald , Jonathan A. Terrett
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00 , C07K14/78 , C07K2319/00 , C12N9/6489 , C12N2799/026
摘要： The present invention relates to novel anti-angiogenic proteins, related to thrombospondin. More specifically, isolated nucleic acid molecules are provided encoding human METH1 and METH2. METH1 and METH2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for the prognosis of cancer and therapeutic methods for treating individuals in need of an increased amount of METH1 or METH2. Also provided are methods for inhibiting angiogenesis using METH1 or METH2.
摘要翻译： 本发明涉及与血小板反应蛋白相关的新型抗血管生成蛋白。 更具体地，提供编码人METH1和METH2的分离的核酸分子。 还提供了METH1和METH2多肽，以及载体，宿主细胞和用于制备它们的重组方法。 还提供了用于预测癌症的诊断方法和用于治疗需要增加量的METH1或METH2的个体的治疗方法。 还提供了使用METH1或METH2抑制血管生成的方法。
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公开(公告)号：US20080318835A1
公开(公告)日：2008-12-25
申请号：US12040449
申请日：2008-02-29
申请人： Zdenka L. Jonak , Stephen H. Trulli , James A. Fornwald , Jonathan A. Terrett , Gregg A. Hastings
发明人： Zdenka L. Jonak , Stephen H. Trulli , James A. Fornwald , Jonathan A. Terrett , Gregg A. Hastings
IPC分类号： A61K38/02 , C07H21/04 , C07H21/02 , C12N5/10 , C12P21/02 , C12N15/87 , C12Q1/68 , G01N33/567 , C07K14/47 , C07K16/18 , A61K31/711 , A61K48/00
CPC分类号： C12N9/6489 , A61K38/00 , A61K48/00 , C07K14/4702 , C12Q1/37 , G01N33/5011 , G01N33/502 , G01N33/564 , G01N33/57496 , G01N33/6893 , G01N33/6896 , G01N2500/00 , G01N2800/102 , G01N2800/164 , G01N2800/24 , G01N2800/2821 , G01N2800/323
摘要： ITGL-TSP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ITGL-TSP polypeptides and polynucleotides in the design of protocols for the treatment of, angiogenic diseases (cancer, cancer metastasis, chronic inflammatory disorders, rheumatoid arthritis, atherosclerosis, macular degeneration, diabetic retmopathy), restenosis, Alzheimer's, disease and tissue remodeling, among others, and diagnostic assays for such conditions.
摘要翻译： 公开了ITGL-TSP多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗血管生成疾病（癌症，癌症转移，慢性炎症性疾病，类风湿性关节炎，动脉粥样硬化，黄斑变性，糖尿病性视网膜病变），再狭窄，阿尔茨海默氏症等的方案中使用ITGL-TSP多肽和多核苷酸的方法。 疾病和组织重塑等，以及这些病症的诊断测定。
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公开(公告)号：US07220557B2
公开(公告)日：2007-05-22
申请号：US09373658
申请日：1999-08-13
申请人： Gregg A. Hastings , Zdenka L. Jonak , Stephen H. Trulli , James A. Fornwald , Jonathan A. Terrett
发明人： Gregg A. Hastings , Zdenka L. Jonak , Stephen H. Trulli , James A. Fornwald , Jonathan A. Terrett
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00 , C07K14/78 , C07K2319/00 , C12N9/6489 , C12N2799/026
摘要： The present invention relates to novel anti-angiogenic proteins, related to thrombospondin. More specifically, isolated nucleic acid molecules are provided encoding human METH1 and METH2. METH1 and METH2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for the prognosis of cancer and therapeutic methods for treating individuals in need of an increased amount of METH1 or METH2. Also provided are methods for inhibiting angiogenesis using METH1 or METH2.
摘要翻译： 本发明涉及与血小板反应蛋白相关的新型抗血管生成蛋白。 更具体地，提供编码人METH1和METH2的分离的核酸分子。 还提供了METH1和METH2多肽，以及载体，宿主细胞和用于制备它们的重组方法。 还提供了用于预测癌症的诊断方法和用于治疗需要增加量的METH1或METH2的个体的治疗方法。 还提供了使用METH1或METH2抑制血管生成的方法。
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公开(公告)号：US5242809A
公开(公告)日：1993-09-07
申请号：US967949
申请日：1992-10-27
摘要： A recombinant DNA molecule comprising the Streptomyces gal operon galK gene; galE gene; galT gene; P1 promoter, P2 promoter, P2 promoter expression unit; P1 promoter regulated region; or the entire Streptomyces gal operon.
摘要翻译： 包含链霉菌gal操纵子galK基因的重组DNA分子; galE基因; galT基因; P1启动子，P2启动子，P2启动子表达单位; P1启动子调控区; 或整个Streptomyces gal操纵子。
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公开(公告)号：US5498529A
公开(公告)日：1996-03-12
申请号：US162506
申请日：1993-12-03
申请人： Thomas R. Berka , James A. Fornwald , Joselina G. Gorniak , Martin Rosenberg , James E. Strickler , Dean P. Taylor
发明人： Thomas R. Berka , James A. Fornwald , Joselina G. Gorniak , Martin Rosenberg , James E. Strickler , Dean P. Taylor
CPC分类号： C07K14/811 , C07K14/36 , C12N15/76 , C07K2319/02
摘要： This invention relates to a process for producing a heterologous polypeptide in Streptomyces which involves transforming a Streptomyces organism with a recombinant DNA molecule comprising an LEP-10 of LTl sequence selected from the group consisting of a sequence encoding a gene expression unit, a promoter sequence or an export control encoding sequence each operatively linked to a heterologous coding sequence and then culturing the transformed Streptomyces such that the heterologous polypeptide is expressed.
摘要翻译： 本发明涉及在链霉菌中生产异源多肽的方法，其涉及用包含LT1序列的LEP-10的重组DNA分子转化链霉菌生物体，所述重组DNA分子选自编码基因表达单位的序列，启动子序列或 一个出口控制编码序列，每一个可操作地连接到异源编码序列，然后培养转化的链霉菌，使得表达异源多肽。
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公开(公告)号：US5279939A
公开(公告)日：1994-01-18
申请号：US894167
申请日：1992-06-03
申请人： Thomas R. Berka , James A. Fornwald , Joselina G. Gorniak , Martin Rosenberg , James E. Strickler , Dean P. Taylor
发明人： Thomas R. Berka , James A. Fornwald , Joselina G. Gorniak , Martin Rosenberg , James E. Strickler , Dean P. Taylor
IPC分类号： C07K14/36 , C07K14/81 , C12N15/76 , C12Q1/68 , C07K13/00 , C07K15/04 , C12N15/00 , C12N15/10 , C12N15/11 , C12N15/31
CPC分类号： C07K14/811 , C07K14/36 , C12N15/76 , C07K2319/02
摘要： This invention relates to novel protein protease inhibitors as well as DNAs encoding same and vectors and transformed host cells useful for the recombinant production of the inhibitors.
摘要翻译： 本发明涉及新的蛋白质蛋白酶抑制剂以及编码它们的DNA，以及用于重组产生抑制剂的载体和转化的宿主细胞。
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公开(公告)号：US5435730A
公开(公告)日：1995-07-25
申请号：US99979
申请日：1993-07-30
摘要： A recombinant DNA molecule comprising the Streptomyces gal operon galK gene; galE gene; galT gene; P1 promoter; P2 promoter; P2 promoter expression unit; P1 promoter regulated region; or the entire Streptomyces gal operon.
摘要翻译： 包含链霉菌gal操纵子galK基因的重组DNA分子; galE基因; galT基因; P1启动子; P2启动子; P2启动子表达单位; P1启动子调控区; 或整个Streptomyces gal操纵子。
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