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公开(公告)号:US20080312146A1
公开(公告)日:2008-12-18
申请号:US11751261
申请日:2007-05-21
申请人: Luisa Iruela-Arispe , Gregg A. Hastings , Steven M. Ruben , Zdenka L. Jonak , Stephen H. Trulli , James A. Fornwald , Jonathan A. Terrett
发明人: Luisa Iruela-Arispe , Gregg A. Hastings , Steven M. Ruben , Zdenka L. Jonak , Stephen H. Trulli , James A. Fornwald , Jonathan A. Terrett
CPC分类号: C07K14/4702 , A61K38/00 , A61K48/00 , C07K14/78 , C07K2319/00 , C12N9/6489 , C12N2799/026
摘要: The present invention relates to novel anti-angiogenic proteins, related to thrombospondin. More specifically, isolated nucleic acid molecules are provided encoding human METH1 and METH2. METH1 and METH2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for the prognosis of cancer and therapeutic methods for treating individuals in need of an increased amount of METH1 or METH2. Also provided are methods for inhibiting angiogenesis using METH1 or METH2.
摘要翻译: 本发明涉及与血小板反应蛋白相关的新型抗血管生成蛋白。 更具体地,提供编码人METH1和METH2的分离的核酸分子。 还提供了METH1和METH2多肽,以及载体,宿主细胞和用于制备它们的重组方法。 还提供了用于预测癌症的诊断方法和用于治疗需要增加量的METH1或METH2的个体的治疗方法。 还提供了使用METH1或METH2抑制血管生成的方法。
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公开(公告)号:US06919433B2
公开(公告)日:2005-07-19
申请号:US09853161
申请日:2001-05-11
申请人: Steven M. Ruben , Craig A. Rosen , Yi Li , Zhizhen Zeng , Hla Kyaw , Carrie L. Fischer , Haodong Li , Daniel R. Soppet , Reiner L. Gentz , Ying-Fei Wei , Paul A. Moore , Paul E. Young , John M. Greene , Ann M. Ferrie , Gregg A. Hastings
发明人: Steven M. Ruben , Craig A. Rosen , Yi Li , Zhizhen Zeng , Hla Kyaw , Carrie L. Fischer , Haodong Li , Daniel R. Soppet , Reiner L. Gentz , Ying-Fei Wei , Paul A. Moore , Paul E. Young , John M. Greene , Ann M. Ferrie , Gregg A. Hastings
CPC分类号: C07K14/47 , A61K38/00 , A61K48/00 , A61K2039/53 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N2799/026
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病,病症和/或病症的诊断和治疗方法。
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公开(公告)号:US08372948B2
公开(公告)日:2013-02-12
申请号:US12264040
申请日:2008-11-03
申请人: Jian Ni , Paul E. Young , Joseph J. Kenny , Henrik S. Olsen , Paul A. Moore , Ying-Fei Wei , John M. Greene , Steven M. Ruben , Ding Liu , Paul R. Crocker
发明人: Jian Ni , Paul E. Young , Joseph J. Kenny , Henrik S. Olsen , Paul A. Moore , Ying-Fei Wei , John M. Greene , Steven M. Ruben , Ding Liu , Paul R. Crocker
IPC分类号: C07K5/00
CPC分类号: C12Q1/6883 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C07K14/70546 , C12N9/6424 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要: The present invention relates to 12 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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公开(公告)号:US08211439B2
公开(公告)日:2012-07-03
申请号:US11929939
申请日:2007-10-30
申请人: Craig A. Rosen , Steven M. Ruben , Olivier Blondel
发明人: Craig A. Rosen , Steven M. Ruben , Olivier Blondel
CPC分类号: C07K14/765 , A61K31/155 , A61K31/426 , A61K31/4439 , A61K31/4965 , A61K38/00 , A61K38/04 , A61K38/17 , A61K38/28 , A61K39/21 , C07K7/06 , C07K14/005 , C07K14/435 , C07K14/4713 , C07K14/4723 , C07K14/475 , C07K14/50 , C07K14/505 , C07K14/51 , C07K14/521 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/575 , C07K14/57563 , C07K14/5759 , C07K14/585 , C07K14/59 , C07K14/60 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/655 , C07K14/665 , C07K14/705 , C07K14/7151 , C07K14/82 , C07K16/00 , C07K16/241 , C07K16/26 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/20 , C07K2319/30 , C07K2319/31 , C12N7/00 , C12N9/0006 , C12N9/0008 , C12N15/62 , C12N2501/335 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12Y101/01105 , C12Y102/01 , C12Y207/01095
摘要: The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译: 本发明包括白蛋白融合蛋白。 编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中,载体含有这些核酸,用这些核酸载体转化的宿主细胞,以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法 酸,载体和/或宿主细胞。 另外,本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗,预防或改善疾病,病症或病症的方法。
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公开(公告)号:US08106165B2
公开(公告)日:2012-01-31
申请号:US11745580
申请日:2007-05-08
申请人: Steven M. Ruben , Craig A. Rosen , Guo-Liang Yu , Jian Ni , Ping Feng
发明人: Steven M. Ruben , Craig A. Rosen , Guo-Liang Yu , Jian Ni , Ping Feng
CPC分类号: C07K14/4748 , A61K38/00 , C07K14/47 , G01N33/566 , G01N2800/00
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病,病症和/或病症的诊断和治疗方法。
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公开(公告)号:US20110081360A1
公开(公告)日:2011-04-07
申请号:US12943722
申请日:2010-11-10
申请人: Viktor Roschke , Craig A. Rosen , Steven M. Ruben
发明人: Viktor Roschke , Craig A. Rosen , Steven M. Ruben
IPC分类号: A61K39/395 , C07H21/04 , C07K16/00 , A61P37/04 , A61P9/00 , A61P17/06 , A61P17/00 , A61P11/00
CPC分类号: C07K14/7158 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K16/24 , C07K16/2866 , C07K2319/00 , C12N2799/026
摘要: The present invention relates to a novel human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to this novel human protein and these novel human antibodies.
摘要翻译: 本发明涉及一种称为人G蛋白趋化因子受体(CCR5)HDGNR10的新型人类蛋白质,以及编码该蛋白质的分离的多核苷酸。 本发明还涉及结合人G蛋白趋化因子受体(CCR5)HDGNR10的人抗体和编码那些抗体的多核苷酸。 还提供了用于产生人G蛋白趋化因子受体(CCR5)HDGNR10和人抗人G蛋白趋化因子受体(CCR5)HDGNR10抗体的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与该新型人蛋白质和这些新型人抗体相关的疾病,病症和/或病症的诊断和治疗方法。
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公开(公告)号:US07906634B2
公开(公告)日:2011-03-15
申请号:US12324825
申请日:2008-11-26
IPC分类号: C07H21/04
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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8.
公开(公告)号:US07879328B2
公开(公告)日:2011-02-01
申请号:US11054515
申请日:2005-02-10
申请人: Steven M. Ruben , Gil H. Choi , Tristan Vaughan , David Hilbert
发明人: Steven M. Ruben , Gil H. Choi , Tristan Vaughan , David Hilbert
IPC分类号: C07K16/00 , C12P21/08 , A61K39/395
CPC分类号: C07K16/2875 , A61K35/12 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07K14/52 , C07K14/70575 , C07K2317/21 , C07K2317/622 , G01N33/5008 , G01N33/5011 , G01N33/5052 , G01N33/5091 , G01N33/564 , G01N33/574 , G01N33/68
摘要: The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.
摘要翻译: 本发明涉及免疫特异性结合B淋巴细胞刺激物的抗体和相关分子。 本发明还涉及用于检测或诊断与异常B淋巴细胞刺激物表达或B淋巴细胞刺激因子不适当功能相关的疾病或病症的方法和组合物,其包含免疫特异性结合B淋巴细胞刺激物的抗体或其片段或变体或相关分子。 本发明还涉及用于预防,治疗或改善与异常B淋巴细胞刺激物表达或不适当B淋巴细胞刺激因子功能相关的疾病或病症的方法和组合物,包括向动物施用有效量的一种或多种抗体或其片段或变体 或免疫特异性结合B淋巴细胞刺激物的相关分子。
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公开(公告)号:US07838636B1
公开(公告)日:2010-11-23
申请号:US11760578
申请日:2007-06-08
申请人: Steven M. Ruben , Craig A. Rosen , Ying-Fei Wei
发明人: Steven M. Ruben , Craig A. Rosen , Ying-Fei Wei
CPC分类号: C07K14/47
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病,病症和/或病症的诊断和治疗方法。
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公开(公告)号:US20100143246A1
公开(公告)日:2010-06-10
申请号:US12618178
申请日:2009-11-13
申请人: Yanggu Shi , Steven M. Ruben
发明人: Yanggu Shi , Steven M. Ruben
IPC分类号: A61K51/10 , A61K39/395 , A61P35/00 , A61P25/00 , A61P37/00 , A61P19/02 , A61P19/08 , G01N33/53
CPC分类号: C07K16/2866 , C07K2317/76 , G01N33/6869 , G01N2333/7155 , G01N2800/24 , Y10S435/81 , Y10S436/808
摘要: The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human IL17RLP protein. IL17RLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL17RLP activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating, diagnosing, detecting, and/or preventing immune system-related disorders.
摘要翻译: 本发明涉及作为白介素(IL)-17受体家族成员的新型IL17RLP蛋白。 特别地,提供编码人IL17RLP蛋白的分离的核酸分子。 还提供IL17RLP多肽,载体,宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定IL17RLP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗,诊断,检测和/或预防免疫系统相关疾病的治疗方法。
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