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公开(公告)号：US5498529A
公开(公告)日：1996-03-12
申请号：US162506
申请日：1993-12-03
申请人： Thomas R. Berka , James A. Fornwald , Joselina G. Gorniak , Martin Rosenberg , James E. Strickler , Dean P. Taylor
发明人： Thomas R. Berka , James A. Fornwald , Joselina G. Gorniak , Martin Rosenberg , James E. Strickler , Dean P. Taylor
CPC分类号： C07K14/811 , C07K14/36 , C12N15/76 , C07K2319/02
摘要： This invention relates to a process for producing a heterologous polypeptide in Streptomyces which involves transforming a Streptomyces organism with a recombinant DNA molecule comprising an LEP-10 of LTl sequence selected from the group consisting of a sequence encoding a gene expression unit, a promoter sequence or an export control encoding sequence each operatively linked to a heterologous coding sequence and then culturing the transformed Streptomyces such that the heterologous polypeptide is expressed.
摘要翻译： 本发明涉及在链霉菌中生产异源多肽的方法，其涉及用包含LT1序列的LEP-10的重组DNA分子转化链霉菌生物体，所述重组DNA分子选自编码基因表达单位的序列，启动子序列或 一个出口控制编码序列，每一个可操作地连接到异源编码序列，然后培养转化的链霉菌，使得表达异源多肽。
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公开(公告)号：US5279939A
公开(公告)日：1994-01-18
申请号：US894167
申请日：1992-06-03
申请人： Thomas R. Berka , James A. Fornwald , Joselina G. Gorniak , Martin Rosenberg , James E. Strickler , Dean P. Taylor
发明人： Thomas R. Berka , James A. Fornwald , Joselina G. Gorniak , Martin Rosenberg , James E. Strickler , Dean P. Taylor
IPC分类号： C07K14/36 , C07K14/81 , C12N15/76 , C12Q1/68 , C07K13/00 , C07K15/04 , C12N15/00 , C12N15/10 , C12N15/11 , C12N15/31
CPC分类号： C07K14/811 , C07K14/36 , C12N15/76 , C07K2319/02
摘要： This invention relates to novel protein protease inhibitors as well as DNAs encoding same and vectors and transformed host cells useful for the recombinant production of the inhibitors.
摘要翻译： 本发明涉及新的蛋白质蛋白酶抑制剂以及编码它们的DNA，以及用于重组产生抑制剂的载体和转化的宿主细胞。
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公开(公告)号：US06444208B1
公开(公告)日：2002-09-03
申请号：US09213011
申请日：1998-12-16
IPC分类号： C12N922
CPC分类号： C12N9/22 , A61K38/00 , A61K39/00 , Y10S530/82 , Y10S530/825
摘要： The invention provides rnc polypeptides and DNA (RNA) encoding rnc polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing rnc polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了rnc多肽和编码rnc多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还提供了利用rnc多肽筛选抗菌化合物的方法。
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公开(公告)号：US06348582B1
公开(公告)日：2002-02-19
申请号：US08936165
申请日：1997-09-23
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto
IPC分类号： C07H2100
CPC分类号： C12N9/0006 , A61K38/00 , A61K39/00 , C07K14/31 , C07K2319/00 , C12N9/00 , C12N9/1205 , C12N9/88 , Y10S435/883
摘要： The invention provides novel polypeptides and polynucleotides encoding such polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了编码这种多肽的新型多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用这些多肽筛选抗菌化合物的方法。
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公开(公告)号：US06274376B1
公开(公告)日：2001-08-14
申请号：US08923511
申请日：1997-09-04
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Andrew Fosberry , Elizabeth J Lawlor
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Andrew Fosberry , Elizabeth J Lawlor
IPC分类号： C12N1500
CPC分类号： C07K16/1275 , A61K39/00 , C07K14/31 , C12N9/78 , C12Y305/04025
摘要： The invention provides clpL polypeptides and DNA (RNA) encoding clpL polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing clpL polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了clpL多肽和编码clpL多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还提供了利用clpL多肽筛选抗菌化合物的方法。
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公开(公告)号：US06274361B1
公开(公告)日：2001-08-14
申请号：US09080662
申请日：1998-05-18
申请人： Sanjoy Biswas , Martin K. R. Burnham , Andrew P. Fosberry , John E Hodgson , Elizabeth J Lawlor , Tong Li , Damien McDevitt , Christopher Michael Traini , Martin Rosenberg , Judith Ward , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , Martin K. R. Burnham , Andrew P. Fosberry , John E Hodgson , Elizabeth J Lawlor , Tong Li , Damien McDevitt , Christopher Michael Traini , Martin Rosenberg , Judith Ward , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C12N916
CPC分类号： C12N9/18
摘要： The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供第p多肽和编码第p多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用第p多肽筛选抗菌化合物的方法。
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公开(公告)号：US06264955B1
公开(公告)日：2001-07-24
申请号：US09224502
申请日：1998-12-31
申请人： Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham
发明人： Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham
IPC分类号： A61K3902
CPC分类号： C07K16/1275 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K14/31 , C12N9/78 , C12Y305/04025
摘要： The invention provides Ferrichrome transport ATP-Binding Protein polypeptides and DNA (RNA) encoding Ferrichrome transport ATP-Binding Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Ferrichrome transport ATP-Binding Protein polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了Ferrichrome转运ATP结合蛋白多肽和编码Ferrichrome转运ATP结合蛋白多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还提供了利用Ferrichrome转运ATP结合蛋白多肽筛选抗菌化合物的方法。
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公开(公告)号：US6165462A
公开(公告)日：2000-12-26
申请号：US345603
申请日：1999-06-29
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号： G01N33/50 , A61K31/70 , A61K38/00 , A61K38/04 , A61K38/44 , A61K38/55 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/04 , A61P35/00 , A61P37/00 , A61P37/04 , A61P43/00 , C07K14/31 , C07K16/12 , C12N1/00 , C12N1/21 , C12N9/00 , C12N9/04 , C12N9/12 , C12N9/14 , C12N9/88 , C12N15/00 , C12N15/09 , C12N15/31 , C12N15/53 , C12N15/54 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/19 , C12R1/44 , C12R1/445 , G01N33/15 , G01N33/53 , G01N33/569 , G01N33/573 , A61K38/51 , C07H21/04 , C12N1/20
CPC分类号： C12N9/0006 , A61K38/00 , A61K39/00 , C07K14/31 , C07K2319/00 , C12N9/00 , C12N9/1205 , C12N9/88 , Y10S435/883
摘要： The invention provides sugar kinase polypeptides and DNA (RNA) encoding sugar kunase polypepties and methods for producing such polypeptides by recombinant techniques. Also provided are methods or utlizng sugar kinase polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供糖激酶多肽和编码糖kunase多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了筛选抗菌化合物的方法或使用糖激酶多肽。
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公开(公告)号：US6107071A
公开(公告)日：2000-08-22
申请号：US910505
申请日：1997-08-04
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号： G01N33/50 , A61K31/70 , A61K38/00 , A61K38/04 , A61K38/44 , A61K38/55 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/04 , A61P35/00 , A61P37/00 , A61P37/04 , A61P43/00 , C07K14/31 , C07K16/12 , C12N1/00 , C12N1/21 , C12N9/00 , C12N9/04 , C12N9/12 , C12N9/14 , C12N9/88 , C12N15/00 , C12N15/09 , C12N15/31 , C12N15/53 , C12N15/54 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/19 , C12R1/44 , C12R1/445 , G01N33/15 , G01N33/53 , G01N33/569 , G01N33/573 , C07H21/04 , C12N1/20
CPC分类号： C12N9/0006 , C07K14/31 , C12N9/00 , C12N9/1205 , C12N9/88 , A61K38/00 , A61K39/00 , C07K2319/00 , Y10S435/883
摘要： The invention provides histidinol dehydrogenase polypeptides and DNA (RNA) encoding histidinol dehydrogenase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidinol dehydrogenase polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供组氨醇脱氢酶多肽和编码组氨醇脱氢酶多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用组氨醇脱氢酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US6008030A
公开(公告)日：1999-12-28
申请号：US918249
申请日：1997-08-25
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号： G01N33/50 , A61K31/70 , A61K38/00 , A61K38/04 , A61K38/44 , A61K38/55 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/04 , A61P35/00 , A61P37/00 , A61P37/04 , A61P43/00 , C07K14/31 , C07K16/12 , C12N1/00 , C12N1/21 , C12N9/00 , C12N9/04 , C12N9/12 , C12N9/14 , C12N9/88 , C12N15/00 , C12N15/09 , C12N15/31 , C12N15/53 , C12N15/54 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/19 , C12R1/44 , C12R1/445 , G01N33/15 , G01N33/53 , G01N33/569 , G01N33/573 , C12N1/20 , C12P21/06
CPC分类号： C12N9/0006 , C07K14/31 , C12N9/00 , C12N9/1205 , C12N9/88 , A61K38/00 , A61K39/00 , C07K2319/00 , Y10S435/883
摘要： The invention provides sugar kinase polypeptides and DNA (RNA) encoding sugar kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing sugar kinase polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了糖激酶多肽和编码糖激酶多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用糖激酶多肽筛选抗菌化合物的方法。
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