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公开(公告)号：US10962707B2
公开(公告)日：2021-03-30
申请号：US16427540
申请日：2019-05-31
IPC分类号： C03B37/027 , G02B6/02 , C03B37/012 , C03C13/04
摘要： A method includes drawing a fiber from a set of substances that includes an elastomer having a first thermal expansion coefficient. The set of substances also includes a glassy polymer having a second thermal expansion coefficient that is higher than the first thermal expansion coefficient. The method also includes extending and then releasing, under ambient temperature conditions, the fiber to increase elastic responsiveness of the fiber to thermal actuation.
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2.发明申请公开(公告)号：US20200001104A1
公开(公告)日：2020-01-02
申请号：US16427911
申请日：2019-05-31
IPC分类号： A61N2/06 , A61K41/00 , C12N5/079 , C12N5/0793 , C12N13/00
摘要： The present invention provides novel methods and devices for the remote stimulation of mechanosensitive cells using magnetically-induced forces that are significantly lower in magnitude than currently possible. Novel biocompatible anisotropic magnetic nanodiscs allow for remote magnetomechanical stimulation of cell signaling in mechanosensitive cells at scale without compromising cell viability. The methods and devices of the present invention allow for investigation of mechanoreception in general, and in particular, for studies in neurological, neurodegenerative; and neuromuscular diseases.
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公开(公告)号：US11672888B2
公开(公告)日：2023-06-13
申请号：US16695932
申请日：2019-11-26
CPC分类号： A61L27/56 , A61L27/16 , A61L27/26 , A61L27/3675 , A61L27/3687 , A61L27/3691 , A61L2430/32
摘要： Methods for generating porous scaffolds may include tuning a porogen/crystallite's particle size to a desired range and mixing the crystallite particles with a polymer solution. The mixture is then cast to form films. The films are rolled and consolidated around another inner material to create a preform, which is then thermally drawn. The inner material and the porogen can be selectively removed to obtain porous constructs/fibers. The structures can be fuse-printed to produce complex tissue scaffolds with dimensions up to several centimeters and beyond.
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公开(公告)号：US09681979B2
公开(公告)日：2017-06-20
申请号：US14556787
申请日：2014-12-01
摘要： A predetermined spatial locale is selectively operationally stimulated through local heating by exposing magnetic particle(s) associated with such local to alternating magnetic field parameters of which are chosen to generate hysteretic losses in magnetic particle(s). When different types of particles are associated with different locales such as different biological cells, different cells can be accessed and stimulated independently from one another. Switching between stimulation of first and second types of cells is carried out by changing parameters of stimulating magnetic field, while optionally maintaining the field strength-frequency product substantially constant. Embodiments facilitate multiplexed release of chemical payloads, triggering changes in electrical polarization, and changing a shape of a unit placed at the chosen locale.
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公开(公告)号：US20170143854A1
公开(公告)日：2017-05-25
申请号：US15359606
申请日：2016-11-22
IPC分类号： A61K49/18
CPC分类号： A61K49/1818 , A61K49/1833 , C01G49/0018 , C01G49/0063 , C01G49/04 , C01G49/06 , C01G49/08 , C01P2002/72 , C01P2004/04 , C01P2004/64 , C01P2006/42
摘要： Magnetic nanoparticles and synthesis of synthesis are described.
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公开(公告)号：US20150150714A1
公开(公告)日：2015-06-04
申请号：US14556787
申请日：2014-12-01
IPC分类号： A61F7/00
摘要： A predetermined spatial locale is selectively operationally stimulated through local heating by exposing magnetic particle(s) associated with such local to alternating magnetic field parameters of which are chosen to generate hysteretic losses in magnetic particle(s). When different types of particles are associated with different locales such as different biological cells, different cells can be accessed and stimulated independently from one another. Switching between stimulation of first and second types of cells is carried out by changing parameters of stimulating magnetic field, while optionally maintaining the field strength-frequency product substantially constant. Embodiments facilitate multiplexed release of chemical payloads, triggering changes in electrical polarization, and changing a shape of a unit placed at the chosen locale.
摘要翻译： 选择性地操作地通过局部加热来激励预定的空间区域，通过暴露与其选择的磁性粒子相关联的磁性粒子来产生磁性颗粒中的滞后损失。 当不同类型的颗粒与诸如不同生物细胞的不同区域相关联时，可以彼此独立地访问和刺激不同的细胞。 在第一和第二类型的细胞的刺激之间的切换是通过改变刺激磁场的参数来实现的，同时可选地保持场强频率乘积基本恒定。 实施例有助于化学有效载荷的多路复用，触发电极化的变化，以及改变放置在所选区域的单元的形状。
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