公开(公告)号：US20050169925A1

公开(公告)日：2005-08-04

申请号：US10505313

申请日：2003-02-20

申请人： Michael Bardroff ,  Bernd Bohrmann ,  Manfred Brockhaus ,  Walter Huber ,  Titus Kretzschmar ,  Hansruedi Loetscher ,  Corinna Lohning ,  Christer Nordstedt ,  Christine Rothe

发明人： Michael Bardroff ,  Bernd Bohrmann ,  Manfred Brockhaus ,  Walter Huber ,  Titus Kretzschmar ,  Hansruedi Loetscher ,  Corinna Lohning ,  Christer Nordstedt ,  Christine Rothe

IPC分类号： C12N15/09 ,  A61K39/00 ,  A61K39/395 ,  A61P25/00 ,  A61P25/28 ,  C07K14/47 ,  C07K16/18 ,  C07K16/46 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/08 ,  G01N33/68 ,  C07K16/40

CPC分类号： C07K16/18 ,  A61K39/0007 ,  A61K2039/505 ,  C07K14/4711 ,  G01N33/6896

摘要： The present invention relates to antibody molecules capable of specifically recognizing two regions of the R-A4 peptide, wherein the first region comprises the amino acid sequence ABFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.

摘要翻译： 本发明涉及能够特异性识别R-A4肽的两个区域的抗体分子，其中第一区域包含如SEQ ID NO：1所示的氨基酸序列ABFRHDSGY或其片段，其中第二区域包含氨基酸 酸序列VHHQKLVFFAEDVG，如SEQ ID NO：2所示或其片段。 此外，公开了编码本发明抗体分子的核酸分子和包含所述核酸分子的载体和宿主。 此外，本发明提供包含本发明化合物以及本发明的抗体分子，核酸分子，载体或宿主的特定用途的组合物，优选药物或诊断组合物。

公开(公告)号：US20100172907A1

公开(公告)日：2010-07-08

申请号：US12462119

申请日：2009-07-28

申请人： Michael Bardroff ,  Bernd Bohrmann ,  Manfred Brockhaus ,  Walter Huber ,  Titus kretzschmar ,  Hansruedi Loetscher ,  Corinna Lohning ,  Christer Nordstedt ,  Christine Rothe

发明人： Michael Bardroff ,  Bernd Bohrmann ,  Manfred Brockhaus ,  Walter Huber ,  Titus kretzschmar ,  Hansruedi Loetscher ,  Corinna Lohning ,  Christer Nordstedt ,  Christine Rothe

IPC分类号： A61K39/395 ,  C07K16/00 ,  C07H21/04 ,  C12N15/63 ,  C12N1/21 ,  C12N1/15 ,  C12N1/19 ,  C12N5/10 ,  C12P21/00

CPC分类号： C07K16/18 ,  A61K39/0007 ,  A61K2039/505 ,  C07K14/4711 ,  G01N33/6896

摘要： The present invention relates to antibody molecules capable of specifically recognizing two regions of the β-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.

摘要翻译： 本发明涉及能够特异性识别β-A4肽的两个区域的抗体分子，其中第一区域包含如SEQ ID NO：1所示的氨基酸序列AEFRHDSGY或其片段，其中第二区域包含 如SEQ ID NO：2所示的氨基酸序列VHHQKLVFFAEDVG或其片段。 此外，公开了编码本发明抗体分子的核酸分子和包含所述核酸分子的载体和宿主。 此外，本发明提供包含本发明化合物以及本发明的抗体分子，核酸分子，载体或宿主的特定用途的组合物，优选药物或诊断组合物。

公开(公告)号：US20120225478A1

公开(公告)日：2012-09-06

申请号：US13472781

申请日：2012-05-16

申请人： Michael Bardroff ,  Bernd Bohrmann ,  Manfred Brockhaus ,  Walter Huber ,  Titus Kretzschmar ,  Hansruedi Loetscher ,  Corinna Löhning ,  Christer Nordstedt ,  Christine Rothe

发明人： Michael Bardroff ,  Bernd Bohrmann ,  Manfred Brockhaus ,  Walter Huber ,  Titus Kretzschmar ,  Hansruedi Loetscher ,  Corinna Löhning ,  Christer Nordstedt ,  Christine Rothe

IPC分类号： C12N5/10 ,  C12N15/63 ,  C12N15/64 ,  C12N15/13

CPC分类号： C07K16/18 ,  A61K39/0007 ,  A61K2039/505 ,  C07K14/4711 ,  G01N33/6896

摘要： The present invention relates to antibody molecules capable of specifically recognizing two regions of the β-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.

摘要翻译： 本发明涉及能够特异性识别β-A4肽的两个区域的抗体分子，其中第一区域包含如SEQ ID NO：1所示的氨基酸序列AEFRHDSGY或其片段，其中第二区域包含 如SEQ ID NO：2所示的氨基酸序列VHHQKLVFFAEDVG或其片段。 此外，公开了编码本发明抗体分子的核酸分子和包含所述核酸分子的载体和宿主。 此外，本发明提供包含本发明化合物以及本发明的抗体分子，核酸分子，载体或宿主的特定用途的组合物，优选药物或诊断组合物。

公开(公告)号：US08216577B2

公开(公告)日：2012-07-10

申请号：US12462119

申请日：2009-07-28

申请人： Michael Bardroff ,  Bernd Bohrmann ,  Manfred Brockhaus ,  Walter Huber ,  Titus Kretzschmar ,  Hansruedi Loetscher ,  Corinna Löhning ,  Christer Nordstedt ,  Christine Rothe

发明人： Michael Bardroff ,  Bernd Bohrmann ,  Manfred Brockhaus ,  Walter Huber ,  Titus Kretzschmar ,  Hansruedi Loetscher ,  Corinna Löhning ,  Christer Nordstedt ,  Christine Rothe

IPC分类号： A61K39/395 ,  C07K16/18

CPC分类号： C07K16/18 ,  A61K39/0007 ,  A61K2039/505 ,  C07K14/4711 ,  G01N33/6896

摘要： The present invention relates to antibody molecules capable of specifically recognizing two regions of the β-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.

摘要翻译： 本发明涉及能够特异性识别β-A4肽的两个区域的抗体分子，其中第一区域包含如SEQ ID NO：1所示的氨基酸序列AEFRHDSGY或其片段，其中第二区域包含 如SEQ ID NO：2所示的氨基酸序列VHHQKLVFFAEDVG或其片段。 此外，公开了编码本发明抗体分子的核酸分子和包含所述核酸分子的载体和宿主。 此外，本发明提供包含本发明化合物以及本发明的抗体分子，核酸分子，载体或宿主的特定用途的组合物，优选药物或诊断组合物。

公开(公告)号：US07794719B2

公开(公告)日：2010-09-14

申请号：US10505313

申请日：2003-02-20

申请人： Michael Bardroff ,  Bernd Bohrmann ,  Manfred Brockhaus ,  Walter Huber ,  Titus Kretzschmar ,  Hansruedi Loetscher ,  Corinna Löhning ,  Christer Nordstedt ,  Christine Rothe

发明人： Michael Bardroff ,  Bernd Bohrmann ,  Manfred Brockhaus ,  Walter Huber ,  Titus Kretzschmar ,  Hansruedi Loetscher ,  Corinna Löhning ,  Christer Nordstedt ,  Christine Rothe

IPC分类号： A61K39/395 ,  C07K16/18

CPC分类号： C07K16/18 ,  A61K39/0007 ,  A61K2039/505 ,  C07K14/4711 ,  G01N33/6896

摘要： The present invention relates to antibody molecules capable of specifically recognizing two regions of the R-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.

摘要翻译： 本发明涉及能够特异性识别R-A4肽的两个区域的抗体分子，其中第一区域包含如SEQ ID NO：1所示的氨基酸序列AEFRHDSGY或其片段，其中第二区域包含氨基酸 酸序列VHHQKLVFFAEDVG，如SEQ ID NO：2所示或其片段。 此外，公开了编码本发明抗体分子的核酸分子和包含所述核酸分子的载体和宿主。 此外，本发明提供包含本发明化合物以及本发明的抗体分子，核酸分子，载体或宿主的特定用途的组合物，优选药物或诊断组合物。

公开(公告)号：US08329886B2

公开(公告)日：2012-12-11

申请号：US13472781

申请日：2012-05-16

申请人： Michael Bardroff ,  Bernd Bohrmann ,  Manfred Brockhaus ,  Walter Huber ,  Titus Kretzschmar ,  Hansruedi Loetscher ,  Corinna Löhning ,  Christer Nordstedt ,  Christine Rothe

发明人： Michael Bardroff ,  Bernd Bohrmann ,  Manfred Brockhaus ,  Walter Huber ,  Titus Kretzschmar ,  Hansruedi Loetscher ,  Corinna Löhning ,  Christer Nordstedt ,  Christine Rothe

IPC分类号： C07H21/00

CPC分类号： C07K16/18 ,  A61K39/0007 ,  A61K2039/505 ,  C07K14/4711 ,  G01N33/6896

摘要： The present invention relates to antibody molecules capable of specifically recognizing two regions of the β-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.

摘要翻译： 本发明涉及能够特异性识别β-A4肽的两个区域的抗体分子，其中第一区域包含如SEQ ID NO：1所示的氨基酸序列AEFRHDSGY或其片段，其中第二区域包含 如SEQ ID NO：2所示的氨基酸序列VHHQKLVFFAEDVG或其片段。 此外，公开了编码本发明抗体分子的核酸分子和包含所述核酸分子的载体和宿主。 此外，本发明提供包含本发明化合物以及本发明的抗体分子，核酸分子，载体或宿主的特定用途的组合物，优选药物或诊断组合物。

公开(公告)号：US08273688B2

公开(公告)日：2012-09-25

申请号：US12158181

申请日：2006-12-15

申请人： Markus Enzelberger ,  Stefanie Thiel ,  Josef Prassler ,  Stefanie Urlinger ,  Christine Rothe

发明人： Markus Enzelberger ,  Stefanie Thiel ,  Josef Prassler ,  Stefanie Urlinger ,  Christine Rothe

IPC分类号： C40B40/08 ,  C40B40/10 ,  C40B50/00

CPC分类号： C07K16/00 ,  C07K2317/565

摘要： The present invention is directed to the preparation and use of a collection of antibody heavy chain complementarity determining region 3 (HCDR3) members, where diversity of the collection is a function of the length of the HCDR3 members. The diversity of the collection of HCDR3 regions substantially represents the natural amino acid distribution of HCDR3 in the human repertoire. This natural amino acid distribution can be represented by biasing the complete random distribution of amino acids, accordingly, in the HCDR3 encoding DNA sequence by using trinucleotide mutagenesis (TRIM) technology. A collection of HCDR3 members of the invention each can be comprised within a variable region of an antibody (or fragment thereof) to form a library of synthetic antibodies or antibody fragments. The invention also provides nucleic acid molecules encoding such diverse collection and methods of making and using the same.

摘要翻译： 本发明涉及抗体重链互补决定区3（HCDR3）成员的集合的制备和使用，其中集合的多样性是HCDR3成员的长度的函数。 HCDR3区域的多样性基本上代表HCDR3在人体内的天然氨基酸分布。 通过使用三核苷酸诱变（TRIM）技术，通过偏置氨基酸的完全随机分布，因此在编码DNA序列的HCDR3中可以表示天然氨基酸分布。 本发明的HCDR3成员的集合各自可以包含在抗体（或其片段）的可变区内，以形成合成抗体或抗体片段的文库。 本发明还提供了编码这种不同收集物的核酸分子及其制备和使用方法。