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    Antibodies Against Amyloid Beta 4 With Glycosylated in the Variable Region
    7.
    发明申请
    Antibodies Against Amyloid Beta 4 With Glycosylated in the Variable Region 有权
    抗变性区域中抗糖蛋白β4的抗体

    公开(公告)号：US20090252724A1

    公开(公告)日：2009-10-08

    申请号：US12086309

    申请日：2006-12-11

    申请人： Hansruedi Loetscher ,  Walter Huber ,  Diana Schuhbauer ,  Karl Weyer ,  Manfred Brockhaus ,  Bernd Bohrmann ,  Hans Koll ,  Andreas Schaubmar ,  Kurt Lang

    发明人： Hansruedi Loetscher ,  Walter Huber ,  Diana Schuhbauer ,  Karl Weyer ,  Manfred Brockhaus ,  Bernd Bohrmann ,  Hans Koll ,  Andreas Schaubmar ,  Kurt Lang

    IPC分类号： A61K39/395 ,  C07K16/00 ,  A61P25/28

    CPC分类号： A61K39/3955 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/77

    摘要： The present invention relates to a purified antibody molecule preparation being characterized in that at least one antigen binding site comprises a glycosylated asparagine (Asn) in the variable region of the heavy chain (VH). More specifically, a pharmaceutical and a diagnostic composition comprising said antibody molecule and antibody mixtures are provided which is/are capable of specifically recognizing the β-A4 peptide/Aβ4. The present invention relates in particular to a mixture of antibodies comprising one or two glycosylated antigen binding sites with a glycosylated asparagine (Asn) in the variable region of the heavy chain, i.e. mixtures of isoforms of antibodies which comprise a glycosylated Asn in the variable region of the heavy chain (VH). Also disclosed are compositions or antibody preparations comprising the specifically glycosylated antibody isoforms. Furthermore, the pharmaceutical and diagnostic uses for these antibodies are provided. The antibody isoforms may for example be used in the pharmaceutical intervention of amyloidogenesis or amyloid-plaque formation and/or in the diagnosis of the same.

    摘要翻译： 本发明涉及纯化的抗体分子制剂，其特征在于至少一个抗原结合位点包含重链可变区（VH）中的糖基化天冬酰胺（Asn）。 更具体地，提供了包含所述抗体分子和抗体混合物的药物和诊断组合物，其能够特异性识别β-A4肽/Aβ4。 本发明特别涉及包含一个或两个糖基化抗原结合位点与重链可变区中的糖基化天冬酰胺（Asn）的抗体的混合物，即包含可变区中的糖基化Asn的抗体同种型的混合物 的重链（VH）。 还公开了包含特异性糖基化抗体同种型的组合物或抗体制剂。 此外，提供了这些抗体的药物和诊断用途。 抗体同种型可以例如用于淀粉样变形或淀粉样蛋白斑形成的药物干预和/或其诊断。

    Antibodies against amyloid beta 4 with glycosylation in the variable region
    8.
    发明授权
    Antibodies against amyloid beta 4 with glycosylation in the variable region 有权
    在可变区域中具有糖基化的淀粉样蛋白β4的抗体

    公开(公告)号：US08906370B2

    公开(公告)日：2014-12-09

    申请号：US12086309

    申请日：2006-12-11

    申请人： Hansruedi Loetscher ,  Walter Huber ,  Diana Schuhbauer ,  Karl Weyer ,  Manfred Brockhaus ,  Bernd Bohrmann ,  Hans Koll ,  Andreas Schaubmar ,  Kurt Lang

    发明人： Hansruedi Loetscher ,  Walter Huber ,  Diana Schuhbauer ,  Karl Weyer ,  Manfred Brockhaus ,  Bernd Bohrmann ,  Hans Koll ,  Andreas Schaubmar ,  Kurt Lang

    IPC分类号： A61K39/395 ,  C07K16/18 ,  A61P25/28 ,  A61K39/00

    CPC分类号： A61K39/3955 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/77

    摘要： The present invention relates to a purified antibody molecule preparation being characterized in that at least one antigen binding site comprises a glycosylated asparagine (Asn) in the variable region of the heavy chain (VH). More specifically, a pharmaceutical and a diagnostic composition comprising said antibody molecule and antibody mixtures are provided which is/are capable of specifically recognizing the β-A4 peptide/Aβ4. The present invention relates in particular to a mixture of antibodies comprising one or two glycosylated antigen binding sites with a glycosylated asparagine (Asn) in the variable region of the heavy chain, i.e. mixtures of isoforms of antibodies which comprise a glycosylated Asn in the variable region of the heavy chain (VH). Also disclosed are compositions or antibody preparations comprising the specifically glycosylated antibody isoforms. Furthermore, the pharmaceutical and diagnostic uses for these antibodies are provided. The antibody isoforms may for example be used in the pharmaceutical intervention of amyloidogenesis or amyloid-plaque formation and/or in the diagnosis of the same.

    摘要翻译： 本发明涉及纯化的抗体分子制剂，其特征在于至少一个抗原结合位点包含重链可变区（VH）中的糖基化天冬酰胺（Asn）。 更具体地，提供了包含所述抗体分子和抗体混合物的药物和诊断组合物，其能够特异性识别Aβ-4肽/ A＆bgr; 4。 本发明特别涉及包含一个或两个糖基化抗原结合位点与重链可变区中的糖基化天冬酰胺（Asn）的抗体的混合物，即包含可变区中的糖基化Asn的抗体同种型的混合物 的重链（VH）。 还公开了包含特异性糖基化抗体同种型的组合物或抗体制剂。 此外，提供了这些抗体的药物和诊断用途。 抗体同种型可以例如用于淀粉样变形或淀粉样蛋白斑形成的药物干预和/或其诊断。

    Human TNF receptor
    9.
    发明授权
    Human TNF receptor 失效
    人类TNF受体

    公开(公告)号：US08163522B1

    公开(公告)日：2012-04-24

    申请号：US08444791

    申请日：1995-05-19

    申请人： Manfred Brockhaus ,  Reiner Gentz ,  Dembic Zlatko ,  Werner Lesslauer ,  Hansruedi Lotscher ,  Ernst-Jurgen Schlaeger

    发明人： Manfred Brockhaus ,  Reiner Gentz ,  Dembic Zlatko ,  Werner Lesslauer ,  Hansruedi Lotscher ,  Ernst-Jurgen Schlaeger

    IPC分类号： C12N15/12 ,  C12N15/63 ,  C12N5/10 ,  C12P21/00

    CPC分类号： C07K14/7151 ,  C07K16/2866 ,  C12N2799/026 ,  Y10S930/144

    摘要： The present invention is concerned with non-soluble proteins and soluble or insoluble fragments thereof, which bind TNF, in homogeneous form, as well as their physiologically compatible salts, especially those proteins having a molecular weight of about 55 or 75 kD (non-reducing SDS-PAGE conditions), a process for the isolation of such proteins, antibodies against such proteins, DNA sequences which code for non-soluble proteins and soluble or non-soluble fragments thereof, which bind TNF, as well as those which code for proteins comprising partly of a soluble fragment, which binds TNF, and partly of all domains except the first of the constant region of the heavy chain of human immunoglobulins and the recombinant proteins coded thereby as well as a process for their manufacture using transformed pro- and eukaryotic host cells.

    摘要翻译： 本发明涉及不溶性蛋白质及其可溶性或不溶性片段，其以均质形式结合TNF，以及它们的生理相容性盐，特别是分子量为约55或75kD的蛋白质（非还原型 SDS-PAGE条件），分离这些蛋白质的方法，针对这些蛋白质的抗体，编码结合TNF的不溶性蛋白质的DNA序列和可溶性或非可溶性片段，以及编码蛋白质的蛋白质 其部分包含结合TNF的可溶性片段，以及部分除了人免疫球蛋白重链的恒定区域的第一个区域以外的所有结构域，以及由此编码的重组蛋白质以及其使用转化的真核和真核生物的方法 宿主细胞。

    Human TNF receptor fusion protein
    10.
    发明授权
    Human TNF receptor fusion protein 失效
    人TNF受体融合蛋白

    公开(公告)号：US08063182B1

    公开(公告)日：2011-11-22

    申请号：US08444790

    申请日：1995-05-19

    申请人： Manfred Brockhaus ,  Reiner Gentz ,  Dembic Zlatko ,  Werner Lesslauer ,  Hansruedi Lotscher ,  Ernst-Jurgen Schlaeger

    发明人： Manfred Brockhaus ,  Reiner Gentz ,  Dembic Zlatko ,  Werner Lesslauer ,  Hansruedi Lotscher ,  Ernst-Jurgen Schlaeger

    IPC分类号： C07K14/715 ,  A61P29/00 ,  A61K38/17 ,  C07K19/00 ,  C07H21/04

    CPC分类号： C07K14/7151 ,  C07K16/2866 ,  C12N2799/026 ,  Y10S930/144

    摘要： The present invention is concerned with non-soluble proteins and soluble or insoluble fragments thereof, which bind TNF, in homogeneous form, as well as their physiologically compatible salts, especially those proteins having a molecular weight of about 55 or 75 kD (non-reducing SDS-PAGE conditions), a process for the isolation of such proteins, antibodies against such proteins, DNA sequences which code for non-soluble proteins and soluble or non-soluble fragments thereof, which bind TNF, as well as those which code for proteins comprising partly of a soluble fragment, which binds TNF, and partly of all domains except the first of the constant region of the heavy chain of human immunoglobulins and the recombinant proteins coded thereby as well as a process for their manufacture using transformed pro- and eukaryotic host cells.

    摘要翻译： 本发明涉及不溶性蛋白质及其可溶性或不溶性片段，其以均质形式结合TNF，以及它们的生理相容性盐，特别是分子量为约55或75kD的蛋白质（非还原型 SDS-PAGE条件），分离这些蛋白质的方法，针对这些蛋白质的抗体，编码结合TNF的不溶性蛋白质的DNA序列和可溶性或非可溶性片段，以及编码蛋白质的蛋白质 其部分包含结合TNF的可溶性片段，以及部分除了人免疫球蛋白重链的恒定区域的第一个区域以外的所有结构域，以及由此编码的重组蛋白质以及其使用转化的真核和真核生物的方法 宿主细胞。