METHODS OF MAINTAINING GENETIC STABILITY OF INBRED ANIMAL STRAINS
    5.
    发明申请
    METHODS OF MAINTAINING GENETIC STABILITY OF INBRED ANIMAL STRAINS 有权
    维持动植物病原菌遗传稳定性的方法

    公开(公告)号:US20100095389A1

    公开(公告)日:2010-04-15

    申请号:US12536909

    申请日:2009-08-06

    IPC分类号: A01K67/02 A01K67/027

    CPC分类号: A01K67/02 A01K67/00

    摘要: The present invention provides novel methods of maintaining genetic stability of non-human animal inbred strains. In the methods, pedigree-tracked cryopreserved embryos derived from a foundation colony are produced and used to re-establish the foundation colony at appropriate intervals.

    摘要翻译: 本发明提供了维持非人类动物近交系的遗传稳定性的新方法。 在该方法中,产生源自基础菌落的系谱跟踪的低温保存的胚胎并用于以合适的间隔重新建立基础菌落。

    COMPOSITIONS AND METHODS RELATING TO NON-HUMAN ANIMALS MODIFIED TO PROMOTE PRODUCTION OF SELECTED GAMETES
    8.
    发明申请
    COMPOSITIONS AND METHODS RELATING TO NON-HUMAN ANIMALS MODIFIED TO PROMOTE PRODUCTION OF SELECTED GAMETES 有权
    与促进选择游戏生产有关的非人类动物相关的组合物和方法

    公开(公告)号:US20120167242A1

    公开(公告)日:2012-06-28

    申请号:US13337892

    申请日:2011-12-27

    IPC分类号: C12N15/877 C12N5/10

    摘要: Methods and compositions for producing selected non-human mammalian germ cells and gametes and for making non-human animals using the produced germ cells and gametes are provided by the present invention. Methods of generating a non-human embryo and/or animal derived from donor stem cells, methods of generating chimeric non-human animals having substantially all gametes and/or germ cells derived from the donor stem cells, methods of producing a non-human host embryo lacking functional endogenous germ cells and non-human host embryos incapable of developing endogenous gametes of the present invention are described herein.

    摘要翻译: 通过本发明提供用于产生选择的非人哺乳动物生殖细胞和配子以及使用所产生的生殖细胞和配子制备非人动物的方法和组合物。 产生源自供体干细胞的非人胚胎和/或动物的方法,产生具有基本上所有来自供体干细胞的配子和/或生殖细胞的嵌合非人动物的方法,生产非人宿主的方法 本文描述了缺乏功能性内源性生殖细胞的胚胎和不能发育本发明的内源性配子的非人宿主胚胎。