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公开(公告)号：US07964211B2
公开(公告)日：2011-06-21
申请号：US12793217
申请日：2010-06-03
申请人： Modesto Erneta , Zhangwen Wu
发明人： Modesto Erneta , Zhangwen Wu
摘要： The present invention is directed to absorbable microspheres comprising a copolymer formed from greater than 88 to about 99 mole percent ε-caprolactone or p-dioxanone, and about 1 to less than 12 mole percent of a different second monomer selected from the group consisting of glycolide, p-dioxanone, trimethylene carbonate and the lactides and combinations thereof, said microspheres having a particle size ranging from about 5 to 2,000 microns. Also described herein are a method for making such microspheres and formulations comprising such absorbable microspheres.
摘要翻译： 本发明涉及可吸收微球，其包含由大于88至约99摩尔％的ε-己内酯或对二恶烷酮形成的共聚物和约1至小于12摩尔％的选自下组的不同的第二单体： 乙交酯，对二恶烷酮，三亚甲基碳酸酯和丙交酯及其组合，所述微球具有约5至2,000微米的粒度。 本文还描述了制备这种微球体和包含这种可吸收微球体的制剂的方法。
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公开(公告)号：US09119902B2
公开(公告)日：2015-09-01
申请号：US11472777
申请日：2006-06-22
申请人： Modesto Erneta , Zhangwen Wu
发明人： Modesto Erneta , Zhangwen Wu
摘要： The present invention is directed to absorbable microspheres comprising a copolymer formed from greater than 88 to about 99 mole percent ε-caprolactone or p-dioxanone, and about 1 to less than 12 mole percent of a different second monomer selected from the group consisting of glycolide, p-dioxanone, trimethylene carbonate and the lactides and combinations thereof, said microspheres having a particle size ranging from about 5 to 2,000 microns. Also described herein are a method for making such microspheres and formulations comprising such absorbable microspheres.
摘要翻译： 本发明涉及可吸收微球，其包含由大于88至约99摩尔％的ε-己内酯或对二恶烷酮形成的共聚物和约1至小于12摩尔％的选自下组的不同的第二单体： 乙交酯，对二恶烷酮，三亚甲基碳酸酯和丙交酯及其组合，所述微球具有约5至2,000微米的粒度。 本文还描述了制备这种微球体和包含这种可吸收微球体的制剂的方法。
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公开(公告)号：US20070298113A1
公开(公告)日：2007-12-27
申请号：US11472777
申请日：2006-06-22
申请人： Modesto Erneta , Zhangwen Wu
发明人： Modesto Erneta , Zhangwen Wu
摘要： The present invention is directed to absorbable microspheres comprising a copolymer formed from greater than 88 to about 99 mole percent ε-caprolactone or p-dioxanone, and about 1 to less than 12 mole percent of a different second monomer selected from the group consisting of glycolide, p-dioxanone, trimethylene carbonate and the lactides and combinations thereof, said microspheres having a particle size ranging from about 5 to 2,000 microns. Also described herein are a method for making such microspheres and formulations comprising such absorbable microspheres.
摘要翻译： 本发明涉及可吸收的微球，其包含由大于88至约99摩尔％的ε-己内酯或对二恶烷酮形成的共聚物和约1至小于12摩尔％的选自乙交酯的不同的第二单体 ，对二恶烷酮，三亚甲基碳酸酯和丙交酯及其组合，所述微球具有约5至2,000微米的粒度。 本文还描述了制备这种微球体和包含这种可吸收微球体的制剂的方法。
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公开(公告)号：US20100240859A1
公开(公告)日：2010-09-23
申请号：US12793217
申请日：2010-06-03
申请人： Modesto Erneta , Zhangwen Wu
发明人： Modesto Erneta , Zhangwen Wu
IPC分类号： C08G63/78
摘要： The present invention is directed to absorbable microspheres comprising a copolymer formed from greater than 88 to about 99 mole percent ε-caprolactone or p-dioxanone, and about 1 to less than 12 mole percent of a different second monomer selected from the group consisting of glycolide, p-dioxanone, trimethylene carbonate and the lactides and combinations thereof, said microspheres having a particle size ranging from about 5 to 2,000 microns. Also described herein are a method for making such microspheres and formulations comprising such absorbable microspheres.
摘要翻译： 本发明涉及可吸收微球，其包含由大于88至约99摩尔％的ε-己内酯或对二恶烷酮形成的共聚物和约1至小于12摩尔％的选自下组的不同的第二单体： 乙交酯，对二恶烷酮，三亚甲基碳酸酯和丙交酯及其组合，所述微球具有约5至2,000微米的粒度。 本文还描述了制备这种微球体和包含这种可吸收微球体的制剂的方法。
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公开(公告)号：US08580307B2
公开(公告)日：2013-11-12
申请号：US11472830
申请日：2006-06-22
IPC分类号： A61K9/14
CPC分类号： A61K8/025 , A61K8/85 , A61K9/1647 , A61K2800/412 , A61L27/18 , A61L27/50 , A61L27/58 , Y10T428/2982 , C08L67/04
摘要： Absorbable microspheres comprising a copolymer formed from greater than 80 to about 99 mole percent D,L-lactide, L(−)-lactide, D(+)-lactide, or meso-lactide and combinations thereof, and about 1 to less than 20 mole percent of a different second monomer selected from the group consisting of p-dioxanone and trimethylene carbonate and combinations thereof, said microspheres having a particle size ranging from about 5 to 2000 microns. Also described herein are formulations comprising such absorbable microspheres.
摘要翻译： 可吸收的微球包含由大于80-约99摩尔％的D，L-丙交酯，L（ - ） - 丙交酯，D（+） - 丙交酯或内消旋丙交酯及其组合形成的共聚物和约1至小于20 摩尔百分比的选自对二恶烷酮和三亚甲基碳酸酯及其组合的不同的第二单体，所述微球具有约5至2000微米的粒度。 本文还描述了包含这种可吸收微球体的制剂。
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6.发明授权Absorbable copolyesters of poly(ethoxyethylene diglycolate) and glycolide 有权聚（乙氧基乙二醇二乙酸酯）和乙交酯的可吸收共聚酯公开(公告)号：US07868127B2
公开(公告)日：2011-01-11
申请号：US11693118
申请日：2007-03-29
申请人： Sasa Andjelic , Modesto Erneta , Michel Gensini
发明人： Sasa Andjelic , Modesto Erneta , Michel Gensini
CPC分类号： A61L17/12 , A61L31/06 , C08G63/664 , Y10T442/626 , C08L67/04
摘要： A semi-crystalline, absorbable copolyester composition comprising the reaction product of a polycondensation polyester and at least one lactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and diethylene glycol; and the copolyester comprises about 30 to 60% by weight of the polycondensation polyester based on the total weight of the copolyester. Also medical devices such as absorbable sutures comprising such copolyesters and absorbable microspheres comprising such copolyesters and methods of making of such absorbable microspheres.
摘要翻译： 包含缩聚聚酯和至少一种内酯的反应产物的半结晶可吸收的共聚酯组合物，其中所述缩聚聚酯包括二甘醇酸和/或其衍生物与二甘醇的反应产物; 共聚聚酯包含基于共聚酯总重量的约30至60重量％的缩聚聚酯。 还可以使用包括这种共聚酯和包含这种共聚酯的可吸收微球的可吸收缝合线的医疗装置和制造这种可吸收的微球的方法。
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7.发明授权Monomer addition techniques to control manufacturing of bioabsorbable copolymers 有权用于控制生物可吸收性共聚物制造的单体添加技术公开(公告)号：US07148315B2
公开(公告)日：2006-12-12
申请号：US10278494
申请日：2002-10-23
申请人： Modesto Erneta , Terry E. Lawler
发明人： Modesto Erneta , Terry E. Lawler
IPC分类号： C08G63/06
摘要： Monomer addition methodology is provided to adjust monomer addition rates to a polymerization reactor. Advantages of the invention include control of bioabsorbable copolymer structure, improvement of monomer conversion, control of reaction temperature, and reduced reaction time. The overall result is an improved process and enhanced product performance. The technology is particularly useful in the copolymerization of monomers with different reactivity ratios, such as glycolide/lactide copolymers and glycolide/caprolactone copolymers. Monomer reactivity ratios and reaction kinetics are utilized to adjust monomer addition rates.
摘要翻译： 提供单体添加方法以调节单体加入聚合反应器的速率。 本发明的优点包括生物可吸收共聚物结构的控制，单体转化率的提高，反应温度的控制以及反应时间的缩短。 总体结果是改进的过程和增强的产品性能。 该技术在具有不同反应性比例的单体如乙交酯/丙交酯共聚物和乙交酯/己内酯共聚物的共聚中是特别有用的。 单体反应活性比和反应动力学被用于调节单体添加速率。
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公开(公告)号：US4085198A
公开(公告)日：1978-04-18
申请号：US641428
申请日：1975-12-17
申请人： Modesto Erneta
发明人： Modesto Erneta
IPC分类号： C01F5/34
CPC分类号： C01F5/34
摘要： Hydrous magnesium chloride in the form of spray dried particulate material of relatively high density is predried, initially using a dry gas at elevated temperature and for a period of time sufficient to partially hydrolyze the magnesium chloride and reduce the chemically combined water to at least as low as about 3.0%, and thereafter hydrochlorinated to reduce the oxides of Mg to at least as low as about 0.6% as MgO.
摘要翻译： 预先干燥具有较高密度的喷雾干燥颗粒材料的氯化镁水溶液，最初在高温下使用干燥气体并在足以部分水解氯化镁的时间内将化学结合的水降至至少一样 约3.0％，然后氢氯化以将Mg的氧化物还原为至少低至约0.6％作为MgO。
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公开(公告)号：US08394755B2
公开(公告)日：2013-03-12
申请号：US13075362
申请日：2011-03-30
申请人： Sasa Andjelic , Modesto Erneta , Michael J. Fevola , Frank C. Sun
发明人： Sasa Andjelic , Modesto Erneta , Michael J. Fevola , Frank C. Sun
IPC分类号： C11D3/20 , C11D1/68 , C11D3/22 , C11D7/26 , C07D307/00 , C07D309/00
CPC分类号： A61K8/39 , A61K8/604 , A61K2800/48 , A61Q19/10
摘要： Provided are compositions comprising one or more compounds having a structure comprising a node structure with from four to twelve carbon atoms, one or more (poly)glyceryl groups, and one or more hydrophobic moieties, wherein each of the one or more (poly)glyceryl groups is linked to the node structure by a first primary linking group, the one or more hydrophobic moieties are each independently linked either to the node structure by a primary linking group or to one of the (poly)glyceryl groups by a secondary linking group, and wherein the polyglyceryl thickener has an average degree of glyceryl polymerization of from greater than 3 to less than about 11 and an average number of hydrophobic groups per primary linking group of about 0.35 or greater. Also provided are polyglyceryl compounds, compositions comprising water, a surfactant, and a polyglyceryl thickener, as well as, methods of making polyglyceryl compounds and compositions of the present invention.
摘要翻译： 提供的是包含一种或多种具有包含具有四至十二个碳原子的结构结构，一个或多个（多）甘油基和一个或多个疏水部分的结构的化合物的组合物，其中所述一种或多种（聚）甘油基 基团通过第一个主要连接基团与节点结构连接，所述一个或多个疏水性部分各自独立地通过第一连接基团连接到节点结构，或者通过次连接基团连接到（聚）甘油基之一， 并且其中所述聚甘油增稠剂的平均甘油聚合度为大于3至小于约11，并且每个连接基团的疏水基团的平均数为约0.35或更大。 还提供了聚甘油化合物，包含水，表面活性剂和聚甘油增稠剂的组合物，以及制备本发明的聚甘油化合物和组合物的方法。
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公开(公告)号：US20120123104A1
公开(公告)日：2012-05-17
申请号：US13075388
申请日：2011-03-30
申请人： Sasa Andjelic , Modesto Erneta , Michael J. Fevola , Frank C. Sun
发明人： Sasa Andjelic , Modesto Erneta , Michael J. Fevola , Frank C. Sun
IPC分类号： C07H15/10 , C07C69/604 , C07D307/20
CPC分类号： A61K8/39 , A61K8/604 , A61K2800/48 , A61Q19/10
摘要： Provided are compositions comprising one or more compounds having a structure comprising a node structure with from four to twelve carbon atoms, one or more (poly)glyceryl groups, and one or more hydrophobic moieties, wherein each of the one or more (poly)glyceryl groups is linked to the node structure by a first primary linking group, the one or more hydrophobic moieties are each independently linked either to the node structure by a primary linking group or to one of the (poly)glyceryl groups by a secondary linking group, and wherein the polyglyceryl thickener has an average degree of glyceryl polymerization of from greater than 3 to less than about 11 and an average number of hydrophobic groups per primary linking group of about 0.35 or greater. Also provided are polyglyceryl compounds, compositions comprising water, a surfactant, and a polyglyceryl thickener, as well as, methods of making polyglyceryl compounds and compositions of the present invention.
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