公开(公告)号：US11555007B2

公开(公告)日：2023-01-17

申请号：US17073386

申请日：2020-10-18

申请人： Cellix Bio Private Limited

发明人： Mahesh Kandula

IPC分类号： C07C225/28 ,  C07C69/604

摘要： The invention relates to the compounds or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II and formula III and the methods for the treatment of neurological diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, lozenge, spray, intravenous, oral solution, nasal spray, oral solution, suspension, oral spray, buccal mucosal layer tablet, parenteral administration, syrup, or injection. Such compositions may be used to treatment of neurological diseases.

公开(公告)号：US20200308488A1

公开(公告)日：2020-10-01

申请号：US16754409

申请日：2018-11-01

申请人： DIC Corporation

发明人： Kenta Shimizu ,  Masanao Hayashi ,  Yutaka Kadomoto ,  Tetsuo Kusumoto ,  Ayaki Hosono ,  Shinya Yamamoto ,  Masanori Miyamoto ,  Hidetomo Kai

IPC分类号： C09K19/46 ,  C07C69/604 ,  C07D319/06 ,  G02F1/1337

摘要： The compound is represented by general formula (i). In the compound, in a group Ki1, at least two secondary carbon atoms in an alkyl group (a linear alkyl, halogenated alkyl, or cyanogenated alkyl group having 3 to 40 carbon atoms) are replaced with —C(═Xi1)— and/or —CH(—CN)—, where Xi1 is an oxygen atom, a sulfur atom, NH, or NR13; in addition, a group Ai2, a group Ai3, or the group Ki1 includes, as a substituent, at least one Pi1-Spi1- group, where Pi1 is a polymerizable group, and SPi1 is a spacer group or a single bond. The liquid crystal composition including the compound represented by general formula (i) can be adsorbed onto substrates between which a liquid crystal layer is held, and, consequently, without the use of an alignment film, liquid crystal molecules can be maintained in a state in which the liquid crystal molecules are aligned in a vertical direction.

公开(公告)号：US10774059B2

公开(公告)日：2020-09-15

申请号：US16446604

申请日：2019-06-19

申请人： Cellix Bio Private Limited

发明人： Mahesh Kandula

IPC分类号： C07C69/604 ,  C07C69/616 ,  A61K8/37 ,  C07D317/12 ,  A61P29/00

摘要： The disclosures herein provide compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, enantiomers, stereoisomers, solvates, and hydrates thereof. These compounds may be formulated as pharmaceutical compositions. The pharmaceutical compositions may be formulated for oral administration, intravenous, spray, parenteral, lozenge, solution, syrup, sachet, transdermal administration, or injection. Such compositions may be used to treatment of inflammation or its associated complications.

公开(公告)号：US20180244602A9

公开(公告)日：2018-08-30

申请号：US15249061

申请日：2016-08-26

申请人： Massachusetts Institute of Technology

发明人： Timothy M. Swager ,  Yanchuan Zhao ,  Silvia Veleirinho de Oliveira Rocha

IPC分类号： C07C69/604 ,  C07C67/293 ,  B01D53/02 ,  B01J20/26

CPC分类号： C07C69/604 ,  B01D53/02 ,  B01D2253/20 ,  B01D2257/40 ,  B01D2257/7027 ,  B01D2257/704 ,  B01J20/261 ,  C07C67/293

摘要： Methods for mechanochemically synthesizing compositions comprising bridged bicyclic-based compounds such as iptycene-based compounds are generally provided. In some cases, two or more polycyclic aromatic hydrocarbons may be mechanochemically reacted such that the product comprises the bridged bicyclic-based compound. In some embodiments, the product (e.g., the bridged bicyclic compound) may comprise two or more [2.2.2] bicyclic cores. In certain embodiments, the mechanochemical reactions described herein may produce higher order bridged bicyclic-based compounds such as oligoiptcyenes or poly-iptycenes. In certain embodiments, the bridged bicyclic based compound comprises a molecular cage.

公开(公告)号：US20180210114A1

公开(公告)日：2018-07-26

申请号：US15497211

申请日：2017-04-26

申请人： HON HAI PRECISION INDUSTRY CO., LTD.

发明人： HSIU-WEN CHIEN

IPC分类号： G02B1/04 ,  C08G77/04 ,  C07F9/53 ,  C07F7/08 ,  C07D303/16 ,  C07D207/267 ,  C07C245/22 ,  C07C233/09 ,  C07C69/604 ,  C07C69/602 ,  C07C69/54 ,  C07C49/84 ,  C07C49/83 ,  C07C49/82 ,  C07C43/16

CPC分类号： G02B1/043 ,  C07D207/267 ,  C07D303/16 ,  C07F7/0838 ,  C07F7/1804 ,  C07F9/5337 ,  C08G77/04 ,  C08L83/04

摘要： A wetness-retaining ophthalmic lens material comprises an organic monomer, a cross-linking agent, an initiator, a salt, and a solvent. The salt dissolves in the water dissociates a plurality of anions and cations, which bind to water molecules and retard the evaporation of the water molecules, the ophthalmic lens material thus can keep wet for a long time. An ophthalmic lens made of the ophthalmic lens material is also provided.

公开(公告)号：US09969674B2

公开(公告)日：2018-05-15

申请号：US15303939

申请日：2015-04-16

申请人： RATIOPHARM GMBH

发明人： Wolfgang Albrecht ,  Roland Selig ,  Frank Lehmann ,  Richard Guserle ,  Annemarie Maier

IPC分类号： C07C69/60 ,  C07C69/604 ,  A61K31/194 ,  A61K31/22

CPC分类号： C07C69/604 ,  C07C69/60

摘要： The present invention relates to novel compounds, e.g. for use as a medicament. In particular, the present invention relates to novel prodrugs of monomethyl fumarate (MMF) suitable as a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases, for example multiple sclerosis, rheumatoid arthritis and psoriasis.

公开(公告)号：US20180057443A1

公开(公告)日：2018-03-01

申请号：US15249061

申请日：2016-08-26

申请人： Massachusetts Institute of Technology

发明人： Timothy M. Swager ,  Yanchuan Zhao ,  Silvia Veleirinho de Oliveira Rocha

IPC分类号： C07C69/604 ,  C07C67/293 ,  B01D53/02 ,  B01J20/26

CPC分类号： C07C69/604 ,  B01D53/02 ,  B01D2253/20 ,  B01D2257/40 ,  B01D2257/7027 ,  B01D2257/704 ,  B01J20/261 ,  C07C67/293

摘要： Methods for mechanochemically synthesizing compositions comprising bridged bicyclic-based compounds such as iptycene-based compounds are generally provided. In some cases, two or more polycyclic aromatic hydrocarbons may be mechanochemically reacted such that the product comprises the bridged bicyclic-based compound. In some embodiments, the product (e.g., the bridged bicyclic compound) may comprise two or more [2.2.2] bicyclic cores. In certain embodiments, the mechanochemical reactions described herein may produce higher order bridged bicyclic-based compounds such as oligoiptcyenes or poly-iptycenes. In certain embodiments, the bridged bicyclic based compound comprises a molecular cage.

公开(公告)号：US09868690B2

公开(公告)日：2018-01-16

申请号：US14647677

申请日：2013-12-20

申请人： RATIOPHARM GMBH

发明人： Wolfgang Albrecht ,  Roland Selig ,  Sebastian Rabe ,  Richard Guserle ,  Annemarie Maier

IPC分类号： C07C225/22 ,  A61K31/495 ,  A61K31/54 ,  C07C69/604 ,  C07C219/08 ,  C07D295/088 ,  C07D317/40 ,  C07F9/09

CPC分类号： C07C225/22 ,  A61K31/225 ,  A61K31/495 ,  A61K31/54 ,  C07C69/604 ,  C07C219/08 ,  C07D295/088 ,  C07D317/40 ,  C07F9/091

摘要： The present invention relates to novel compounds for use as a medicament. In particular, the present invention relates to novel prodrugs of monomethyl fumarate (MMF) suitable as a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases, for example multiple sclerosis and psoriasis.

公开(公告)号：US09782335B2

公开(公告)日：2017-10-10

申请号：US15133552

申请日：2016-04-20

申请人： ELC Management LLC

发明人： Daniel H. Maes ,  Fatemeh Mohammadi ,  Lisa Qu ,  Anna Czarnota ,  Thomas Mammone ,  Julius R. Zecchino ,  Lieve Declercq

IPC分类号： A61K31/216 ,  A61K8/37 ,  A61K8/34 ,  A61K8/42 ,  A61K8/58 ,  A61K8/60 ,  A61K31/05 ,  A61Q19/00 ,  A61Q1/10 ,  A61Q1/12 ,  A61Q19/08 ,  A61Q1/02 ,  A61Q1/06 ,  A61Q1/08 ,  A61Q17/04 ,  A61K8/97 ,  C07C69/604 ,  A61K8/02 ,  A61K8/06 ,  A61K8/25 ,  C07C69/94 ,  A61K8/891 ,  C07C69/017 ,  C07C69/30

CPC分类号： A61K8/375 ,  A61K8/0241 ,  A61K8/062 ,  A61K8/064 ,  A61K8/066 ,  A61K8/25 ,  A61K8/347 ,  A61K8/37 ,  A61K8/42 ,  A61K8/585 ,  A61K8/60 ,  A61K8/602 ,  A61K8/891 ,  A61K8/97 ,  A61K31/05 ,  A61K2800/31 ,  A61K2800/43 ,  A61K2800/54 ,  A61K2800/591 ,  A61K2800/596 ,  A61Q1/02 ,  A61Q1/06 ,  A61Q1/08 ,  A61Q1/10 ,  A61Q1/12 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08 ,  C07C69/017 ,  C07C69/30 ,  C07C69/604 ,  C07C69/94

摘要： Succinic acid esters of resveratrol and topical compositions containing the esters.

公开(公告)号：US09422226B2

公开(公告)日：2016-08-23

申请号：US14124562

申请日：2012-06-08

申请人： John Guzowski ,  William Kiesman ,  Erwin Irdham

发明人： John Guzowski ,  William Kiesman ,  Erwin Irdham

IPC分类号： C07C67/297 ,  C07C67/52 ,  C07C67/08 ,  C07C69/60 ,  C07C69/604

CPC分类号： C07C67/52 ,  C07B2200/13 ,  C07C67/08 ,  C07C67/297 ,  C07C69/60 ,  C07C69/604

摘要： The present invention describes a process for the preparation of dimethyl fumarate. The process involves the esterification of fumaric acid and methanol in the presence of sulfuric acid as an acid catalyst. The high purity dimethyl fumarate contains no more than trace amounts of dimethyl sulfate. The present invention also provides a process for the preparation of highly pure dimethyl fumarate with a particle size from 20 to 250μπι.

摘要翻译： 本发明描述了制备富马酸二甲酯的方法。 该方法包括在作为酸催化剂的硫酸存在下富马酸和甲醇的酯化。 高纯度富马酸二甲酯含有不超过痕量的硫酸二甲酯。 本发明还提供了制备粒径为20-250μm的高纯度富马酸二甲酯的方法。