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公开(公告)号：US12054701B2
公开(公告)日：2024-08-06
申请号：US17224591
申请日：2021-04-07
发明人： Tomoro Dan , Hiroaki Kii , Takayuki Uozumi , Yoshiko Sato , Shinsuke Yoshida
摘要： A passage timing calculation device includes a processor and a memory encoded with instructions executed by the processor, wherein the instructions causing the processor to perform operations comprising calculating a time change in an area occupied by an extraction target region that is a region in which a striated pattern appears from a plurality of images of pluripotent stem cells captured at different times, detecting a change point of the time change in an area occupied by the extraction target region, and calculating a passage timing of the pluripotent stem cells on the basis of the change point.
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公开(公告)号：US11953498B2
公开(公告)日：2024-04-09
申请号：US17227967
申请日：2021-04-12
申请人： NIKON CORPORATION
发明人： Tomoro Dan , Hiroaki Kii , Takayuki Uozumi , Yasujiro Kiyota
CPC分类号： G01N33/5073 , C12M41/36 , C12Q1/04 , G06T7/0016 , G06T7/11 , G06T2207/10056 , G06T2207/30024 , G06T2207/30242
摘要： An image processing device includes: a processor; and a memory encoded with instructions executed by the processor, including: imaging pluripotent stem cells with time in a culture process and acquiring a plurality of images, extracting a colony region of the cells from the image, extracting a high luminance region on the basis of a group of pixels with larger luminance values than a standard value from among pixels constituting the image, extracting an extraction target region with relatively high contrast in the colony region on the basis of the colony and high luminance regions, and outputting the extraction target region as an extraction result, wherein as a relationship among the colony, high luminance, and extraction target regions, the colony region is formed, the high luminance region is then formed therein, and the extraction target region is then formed in the high luminance region in the culture process of the cells.
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