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公开(公告)号：US11068695B2
公开(公告)日：2021-07-20
申请号：US16124804
申请日：2018-09-07
申请人： NIKON CORPORATION
发明人： Hiroaki Kii , Yasujiro Kiyota , Takayuki Uozumi , Yoichi Yamazaki
摘要： An image processing device includes an image processing unit that performs image processing on an observed image in which a cell is imaged and an image processing method selector that is configured to determine an observed image processing method for analyzing the imaged cell on the basis of information of a processed image obtained through image processing of the image processing unit.
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公开(公告)号：US09845454B2
公开(公告)日：2017-12-19
申请号：US14031605
申请日：2013-09-19
申请人： NIKON CORPORATION
发明人： Takayuki Uozumi
摘要： A culture apparatus includes a culture unit which cultures cells under a predetermined culture environment, and an imaging unit which captures an inspection image showing a state of a culture container which holds the cells or a state of the cells, further includes a carrying unit and a determining unit. The carrying unit delivers the culture container between at least one peripheral device to be used in a culture operation of the cells and the culture apparatus. The determining unit detects completion of the culture operation of the peripheral device, controls the imaging unit to capture the inspection image, and analyzes the inspection image to determine whether or not the culture operation by the peripheral device is appropriate.
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公开(公告)号：US11953498B2
公开(公告)日：2024-04-09
申请号：US17227967
申请日：2021-04-12
申请人： NIKON CORPORATION
发明人： Tomoro Dan , Hiroaki Kii , Takayuki Uozumi , Yasujiro Kiyota
CPC分类号： G01N33/5073 , C12M41/36 , C12Q1/04 , G06T7/0016 , G06T7/11 , G06T2207/10056 , G06T2207/30024 , G06T2207/30242
摘要： An image processing device includes: a processor; and a memory encoded with instructions executed by the processor, including: imaging pluripotent stem cells with time in a culture process and acquiring a plurality of images, extracting a colony region of the cells from the image, extracting a high luminance region on the basis of a group of pixels with larger luminance values than a standard value from among pixels constituting the image, extracting an extraction target region with relatively high contrast in the colony region on the basis of the colony and high luminance regions, and outputting the extraction target region as an extraction result, wherein as a relationship among the colony, high luminance, and extraction target regions, the colony region is formed, the high luminance region is then formed therein, and the extraction target region is then formed in the high luminance region in the culture process of the cells.
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公开(公告)号：US12054701B2
公开(公告)日：2024-08-06
申请号：US17224591
申请日：2021-04-07
发明人： Tomoro Dan , Hiroaki Kii , Takayuki Uozumi , Yoshiko Sato , Shinsuke Yoshida
摘要： A passage timing calculation device includes a processor and a memory encoded with instructions executed by the processor, wherein the instructions causing the processor to perform operations comprising calculating a time change in an area occupied by an extraction target region that is a region in which a striated pattern appears from a plurality of images of pluripotent stem cells captured at different times, detecting a change point of the time change in an area occupied by the extraction target region, and calculating a passage timing of the pluripotent stem cells on the basis of the change point.
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公开(公告)号：US11222423B2
公开(公告)日：2022-01-11
申请号：US16125064
申请日：2018-09-07
发明人： Hiroaki Kii , Yasujiro Kiyota , Takayuki Uozumi , Miho Furue , Mika Suga
IPC分类号： G06K9/00 , G06T7/00 , C12M1/00 , C12Q1/68 , C12M1/36 , G01N15/14 , G02B21/36 , G16B45/00 , G01N21/64 , C12M1/34
摘要： An evaluation device includes a state determination unit which is configured to determine a state of cells which are an observation target under non-standard conditions on the basis of information acquired from an image of cells under standard conditions.
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公开(公告)号：US10466465B2
公开(公告)日：2019-11-05
申请号：US16163125
申请日：2018-10-17
申请人： NIKON CORPORATION
发明人： Hideo Kuroda , Hirotada Watanabe , Yoichi Wada , Yasujiro Kiyota , Takayuki Uozumi , Ryuji Koshiba
摘要： A biological specimen observation apparatus whereby observation of a biological specimen can be performed accurately. In macro observation, a biological change region is extracted from a macro image, a micro observation point corresponding to an extracted biological change region is registered, and an object for tracking is identified. In micro observation, it is judged from the micro image whether or not biological change has continued in the biological change region at the micro observation point, and the registered micro observation point is updated on the basis of this judgment result. It is possible to carry out both macro observation for detecting a biological change region and micro observation for observing the progress of growth of a partial minute region where biological change has been exhibited, and to carry out accurate observation of a biological specimen.
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公开(公告)号：US20190049713A1
公开(公告)日：2019-02-14
申请号：US16163125
申请日：2018-10-17
申请人： NIKON CORPORATION
发明人： Hideo KURODA , Hirotada Watanabe , Yoichi Wada , Yasujiro Kiyota , Takayuki Uozumi , Ryuji Koshiba
CPC分类号： G02B21/367 , G01N21/6486 , G02B21/16 , G02B21/365 , G06K9/00134 , G06K9/0014
摘要： A biological specimen observation apparatus whereby observation of a biological specimen can be performed accurately. In macro observation, a biological change region is extracted from a macro image, a micro observation point corresponding to an extracted biological change region is registered, and an object for tracking is identified. In micro observation, it is judged from the micro image whether or not biological change has continued in the biological change region at the micro observation point, and the registered micro observation point is updated on the basis of this judgment result. It is possible to carry out both macro observation for detecting a biological change region and micro observation for observing the progress of growth of a partial minute region where biological change has been exhibited, and to carry out accurate observation of a biological specimen.
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公开(公告)号：US10163218B2
公开(公告)日：2018-12-25
申请号：US15022806
申请日：2014-09-12
申请人： NIKON CORPORATION
发明人： Kei Nakagawa , Masafumi Mimura , Takayuki Uozumi
IPC分类号： G06K9/00 , G06T7/20 , C12M1/00 , C12M1/34 , C12N5/077 , G01N33/483 , G06T7/00 , G06T7/215 , G06T7/246
摘要： An image analysis device includes a first calculating part that calculates a magnitude of motion of an image element from time-series images of pulsating myocardial cells, a second calculating part that calculates a feature quantity on the basis of the magnitude of the motion of the image element calculated by the first calculating part, and an identifying part that identifies whether the image element is a predetermined image element on the basis of the feature quantity calculated by the second calculating part.
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公开(公告)号：US10133054B2
公开(公告)日：2018-11-20
申请号：US15220725
申请日：2016-07-27
申请人： NIKON CORPORATION
发明人： Hideo Kuroda , Hirotada Watanabe , Yoichi Wada , Yasujiro Kiyota , Takayuki Uozumi , Ryuji Koshiba
摘要： A biological specimen observation apparatus whereby observation of a biological specimen can be performed accurately. In macro observation, a biological change region is extracted from a macro image, a micro observation point corresponding to an extracted biological change region is registered, and an object for tracking is identified. In micro observation, it is judged from the micro image whether or not biological change has continued in the biological change region at the micro observation point, and the registered micro observation point is updated on the basis of this judgment result. It is possible to carry out both macro observation for detecting a biological change region and micro observation for observing the progress of growth of a partial minute region where biological change has been exhibited, and to carry out accurate observation of a biological specimen.
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