公开(公告)号：US20180303941A1

公开(公告)日：2018-10-25

申请号：US15529288

申请日：2015-11-25

Applicant: Northwestern University

Inventor： Guillermo A. AMEER ,  Michele JEN

IPC: A61K47/32 ,  A61K38/50 ,  A61P17/02 ,  A61K9/00 ,  A61K47/10 ,  A61K47/34 ,  A61L15/24 ,  A61L15/44 ,  A61L15/60 ,  A61L15/64 ,  A61L15/62 ,  A61K48/00

CPC classification number: A61K47/32 ,  A61K9/0014 ,  A61K38/50 ,  A61K47/10 ,  A61K47/34 ,  A61K48/0016 ,  A61K48/005 ,  A61L15/24 ,  A61L15/44 ,  A61L15/60 ,  A61L15/62 ,  A61L15/64 ,  A61L2300/412 ,  A61L2300/604 ,  A61L2430/34 ,  A61P17/02 ,  C12N2800/95 ,  C12Y305/01

Abstract: Compositions and methods are provided for improved wound healing. In particular, provided herein are compositions and methods for the direct delivery of Sirtuin-1 (Sirt1) or vectors encoding Sirt1 to the wounds (e.g., of diabetic patients). In some embodiments, provided herein are therapeutic devices comprising: (a) a vector encoding Sirtuin-1 (Sirt 1); and (b) a hydrogel carrier. In some embodiments, the vector comprises a viral vector comprising a polynucleotide sequence encoding Sirt 1. In some embodiments, the vector comprises a non-viral vector comprising a polynucleotide sequence encoding Sirt1.

公开(公告)号：US20240352186A1

公开(公告)日：2024-10-24

申请号：US18640956

申请日：2024-04-19

Applicant: Northwestern University

Inventor： Guillermo A. AMEER ,  Rebecca L. KEATE ,  Jonathan RIVNAY

IPC: C08G63/91 ,  A61L27/18 ,  C08G81/00 ,  C08J5/18

CPC classification number: C08G63/916 ,  A61L27/18 ,  C08G81/00 ,  C08J5/18 ,  C08J2367/02

Abstract: Provided herein are citrate-based elastomeric materials comprising conductive polymers, such as poly(3,4-ethylenedioythiophene) (PEDOT)-poly(1,8-octamethylene-citrate-co-octanol) (POCO), and methods of use therefor for medical applications, such as tissue engineering.

公开(公告)号：US20250129184A1

公开(公告)日：2025-04-24

申请号：US19000075

申请日：2024-12-23

Applicant: Northwestern University

Inventor： Guillermo A. AMEER ,  Yunxiao Zhu

IPC: C07K19/00 ,  A61F2/07 ,  A61K9/08 ,  A61K38/00 ,  A61K47/61 ,  A61K47/62 ,  A61P7/02 ,  C07K7/06 ,  C07K14/745 ,  C08B37/00 ,  G01N33/86

Abstract: Provided herein is technology relating to anticoagulant therapies and particularly, but not exclusively, to anticoagulant compositions for localized and targeted administration and related methods and kits for treatment of a subject with a localized and targeted anticoagulant therapy.

公开(公告)号：US20210008246A1

公开(公告)日：2021-01-14

申请号：US16646848

申请日：2018-09-13

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Guillermo A. AMEER ,  Henry Oliver Tenadooah WARE ,  Cheng SUN ,  Congwen DUAN

IPC: A61L27/16 ,  A61L27/12 ,  A61L27/04 ,  A61L27/10 ,  A61L27/58 ,  B33Y70/00 ,  B29C64/124 ,  B33Y10/00 ,  B29C35/02 ,  B33Y40/20 ,  B29C64/30

Abstract: Provided herein photo-reactive inks, thermal-curable materials and objects (e.g., medical implants, scaffolds, devices, etc.) made therefrom, and methods of preparation and use thereof.