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1.发明授权Aryl and heteroaryl sulfones as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction 有权芳基和杂芳基砜作为mGluR4变构增效剂，组合物和治疗神经功能障碍的方法公开(公告)号：US08912336B2
公开(公告)日：2014-12-16
申请号：US13508535
申请日：2010-11-08
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Yiu-Yin Cheung
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Yiu-Yin Cheung
IPC分类号： C07D401/04 , C07D417/04 , C07D213/81 , C07D239/28 , C07D307/56
CPC分类号： C07D401/04 , C07D213/81 , C07D239/28 , C07D307/56 , C07D417/04
摘要： In one aspect, the invention relates to sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 一方面，本发明涉及可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂的砜化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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2.发明申请MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION 失效MGLUR4 ALLOSTERIC电位器，组合物和治疗神经功能障碍的方法公开(公告)号：US20120245153A1
公开(公告)日：2012-09-27
申请号：US13394309
申请日：2010-09-07
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers , Patrick R. Gentry , Yiu-Yin Cheung , James M. Salovich , Rocco D. Gogliotti
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers , Patrick R. Gentry , Yiu-Yin Cheung , James M. Salovich , Rocco D. Gogliotti
IPC分类号： A61K31/542 , A61K31/4985 , A61K31/506 , A61K31/437 , A61K31/4439 , C07D513/04 , C07D498/04 , C07D487/04 , C07D471/04 , C07D401/12 , A61P25/18 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/16 , A61P25/28 , A61K31/5377
CPC分类号： C07D487/04 , C07D401/10 , C07D471/04 , C07D498/04 , C07D513/04
摘要： Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and use thereof.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂的化合物及其用途。
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3.发明授权MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction 失效MGLUR4变构增强剂，组合物和治疗神经功能障碍的方法公开(公告)号：US08779157B2
公开(公告)日：2014-07-15
申请号：US13394309
申请日：2010-09-07
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M Niswender , Darren W. Engers , Patrick R. Gentry , Yiu-Yin Cheung , James M. Salovich , Rocco D. Gogliotti
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M Niswender , Darren W. Engers , Patrick R. Gentry , Yiu-Yin Cheung , James M. Salovich , Rocco D. Gogliotti
IPC分类号： C07D233/00
CPC分类号： C07D487/04 , C07D401/10 , C07D471/04 , C07D498/04 , C07D513/04
摘要： Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and use thereof.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂的化合物及其用途。
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4.发明申请ARYL AND HETEROARYL SULFONES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION 有权ARYL和HETEROARYL SULFONES作为MGLUR4 ALLOSTERIC电位器，组合物和治疗神经功能障碍的方法公开(公告)号：US20120245185A1
公开(公告)日：2012-09-27
申请号：US13508535
申请日：2010-11-08
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Yiu-Yin Cheung
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Yiu-Yin Cheung
IPC分类号： A61K31/4439 , C07D417/04 , A61K31/427 , C07D213/81 , C12N5/02 , C07D307/68 , A61K31/341 , C07D239/28 , A61K31/505 , C07D401/04 , A61K31/4402
CPC分类号： C07D401/04 , C07D213/81 , C07D239/28 , C07D307/56 , C07D417/04
摘要： In one aspect, the invention relates to sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 一方面，本发明涉及可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂的砜化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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5.发明申请SUBSTITUTED ENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS 审中-公开作为MGLUR4电位的替代的杀伤甾烷酰胺和取代的吲哚磺酰胺公开(公告)号：US20120184556A1
公开(公告)日：2012-07-19
申请号：US13386651
申请日：2010-07-23
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Yiu-Yin Cheung
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Yiu-Yin Cheung
IPC分类号： A61K31/53 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/427 , A61K31/506 , A61K31/422 , A61K31/454 , C07D235/18 , C07D401/04 , C07D409/04 , C07D403/04 , C07D417/04 , C07D413/04 , C07D405/04 , A61K31/404 , A61K31/437 , A61K31/5025 , A61K31/4985 , A61K31/519 , C07D471/04 , C07D209/08 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/22 , A61P3/04 , A61P25/08 , A61P35/00 , A61P3/00 , A61P29/00 , A61P25/28 , C12N5/071 , C07D235/08 , C07D401/12 , C07D405/10 , A61K31/4545 , C07D401/14 , A61K31/4184
CPC分类号： A61K31/415 , A61K31/404 , A61K45/06 , C07D235/06 , C07D235/18 , C07D401/04 , C07D401/12 , C07D403/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D417/04 , A61K2300/00
摘要： Disclosed are substituted benzoimidazolesulfonamides and substituted indolesulfonamides as mGluR4 potentiators.
摘要翻译： 公开了取代的苯并咪唑磺酰胺和取代的吲唑磺酰胺作为mGluR4增效剂。
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6.发明申请SUBSTITUTED DIOXOPIPERIDINES AND DIOXOPYRROLIDINES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION 有权替代二氯吡啶和二氧化吡咯烷酮作为MGLUR4 ALLOSTERIC电位器，组合物和治疗神经功能障碍的方法公开(公告)号：US20110124663A1
公开(公告)日：2011-05-26
申请号：US12952640
申请日：2010-11-23
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers
IPC分类号： A61K31/506 , A61K31/4439 , C07D401/12 , A61K31/4725 , A61K31/438 , C07D403/12 , A61K31/427 , C07D417/12 , A61P25/00 , A61P25/16 , C12N5/071
摘要： In one aspect, the invention relates to compounds having a general structure: wherein the variables are defined herein, which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及具有一般结构的化合物：其中变量在本文中定义，其可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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7.发明授权Substituted dioxopiperidines and dioxopyrrolidines as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction 有权取代的二氧代哌啶和二氧代吡咯烷作为MGLUR4变构增效剂，组合物和治疗神经功能障碍的方法公开(公告)号：US08759377B2
公开(公告)日：2014-06-24
申请号：US12952640
申请日：2010-11-23
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers
IPC分类号： A61K31/4439 , C07D401/12
摘要： In one aspect, the invention relates to compounds having a general structure: wherein the variables are defined herein, which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及具有一般结构的化合物：其中变量在本文中定义，其可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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![Substituted 1,1,3,1-tetraoxidobenzo[D][1,3,2]dithiazoles as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction](/abs-image/US/2014/02/25/US08658650B2/abs.jpg.150x150.jpg)
8.发明授权Substituted 1,1,3,1-tetraoxidobenzo[D][1,3,2]dithiazoles as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction 有权取代的1,1,3,1-四氧化苯并[D] [1,3,2]二噻唑作为MGLUR4变构增效剂，组合物和治疗神经功能障碍的方法公开(公告)号：US08658650B2
公开(公告)日：2014-02-25
申请号：US13146909
申请日：2010-01-28
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Rocco D. Gogliotti , Darren W. Engers
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Rocco D. Gogliotti , Darren W. Engers
IPC分类号： A61K31/41 , A61K31/4439 , A61K31/506 , A61K31/444 , C07D417/12 , C07D419/14 , C07D285/01
CPC分类号： C07D285/01 , C07D403/12 , C07D417/12 , C07D417/14
摘要： Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and methods of using the compounds.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂的化合物和使用该化合物的方法。
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![SUBSTITUTED 1,1,3,1-TETRAOXIDOBENZO[D][1,3,2]DITHIAZOLES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION](/abs-image/US/2011/12/29/US20110319429A1/abs.jpg.150x150.jpg)
9.发明申请SUBSTITUTED 1,1,3,1-TETRAOXIDOBENZO[D][1,3,2]DITHIAZOLES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION 有权取代1,1,3,1-三羟基苯并[D] [1,3,2]二甲氧基硅烷作为MGLUR4不同位置电位，组合物和治疗神经功能障碍的方法公开(公告)号：US20110319429A1
公开(公告)日：2011-12-29
申请号：US13146909
申请日：2010-01-28
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Rocco D. Gogliotti , Darren W. Engers
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Rocco D. Gogliotti , Darren W. Engers
IPC分类号： A61K31/41 , C07D417/12 , C07D419/14 , A61K31/4439 , A61K31/506 , A61K31/444 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/22 , A61P3/04 , A61P3/00 , A61P25/08 , A61P35/00 , A61P29/00 , A61P3/10 , A61P25/14 , C07D285/01
CPC分类号： C07D285/01 , C07D403/12 , C07D417/12 , C07D417/14
摘要： Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and methods of using the compounds.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂的化合物和使用该化合物的方法。
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公开(公告)号：US20120028956A1
公开(公告)日：2012-02-02
申请号：US13269977
申请日：2011-10-10
申请人： P. Jeffrey Conn , Craig W. Lindsley , Charles David Weaver , Alice L. Rodriguez , Colleen M. Niswender , Carrie K. Jones , Richard Williams
发明人： P. Jeffrey Conn , Craig W. Lindsley , Charles David Weaver , Alice L. Rodriguez , Colleen M. Niswender , Carrie K. Jones , Richard Williams
IPC分类号： A61K31/4725 , A61K31/496 , A61K31/4375 , A61K31/472 , C07D413/06 , C07D401/06 , C07D471/04 , C07D217/24 , A61P25/24 , C07D401/12 , A61P25/28 , A61P25/00 , A61P25/18 , A61P25/30 , A61P25/08 , A61P25/06 , A61P3/10 , A61P3/04 , A61P3/00 , A61P25/20 , A61P25/22 , A61K31/5377
CPC分类号： A61K31/397 , A61K31/4704 , A61K31/5377 , C07D209/46 , C07D209/48 , C07D217/24 , C07D401/06
摘要： In one aspect, the invention relates to bicyclic mGluR5 positive allosteric modulators, for example 6-(phenylethynyl)-3,4-dihydroisoquinolin-1(2H)-one, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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