公开(公告)号：US20050090442A1

公开(公告)日：2005-04-28

申请号：US10921065

申请日：2004-08-18

申请人： Perry Bartlett ,  Elizabeth Coulson ,  Katrina Fieldew ,  Manuel Baca ,  Trevor Kilpatrick ,  Cheema Surindar

发明人： Perry Bartlett ,  Elizabeth Coulson ,  Katrina Fieldew ,  Manuel Baca ,  Trevor Kilpatrick ,  Cheema Surindar

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C12N15/12 ,  A61K38/17 ,  C12N5/00

CPC分类号： C07K14/70571 ,  A61K38/00 ,  A61K48/00

摘要： The present invention relates generally to a method for modulating cell survival. Modulation of cell survival includes inducing, enhancing or otherwise promoting cell survival such as the survival of neural cells as well as facilitating cell death such as the death of targeted cancer cells. The modulation of cell survival is mediated by a region identified on the p75 neurotrophin receptor (p75NTR) required for death signalling. The present invention further provides genetic molecules which encode the death signalling region of p75NTR which are useful in antagonising death signal function as well as promoting cell death when expressed in targeted cells. The present invention also contemplates recombinant peptides, polypeptides and proteins s well as chemical equivalents, derivatives and homologues thereof which comprise the death signalling portion of p75NTR. Particularly useful molecules of the present invention comprise peptides corresponding to soluble forms of the death signalling portion of p75NTR. These molecules antagonise p75NTR-mediated cell death.

摘要翻译： 本发明一般涉及调节细胞存活的方法。 细胞存活的调节包括诱导，增强或以其他方式促进细胞存活，例如神经细胞的存活以及促进细胞死亡，例如靶向癌细胞的死亡。 细胞存活的调节由死亡信号传导所需的p75神经营养因子受体（p75 NTR）鉴定的区域介导。 本发明进一步提供编码p75 NTR的死亡信号传导区的遗传分子，其可用于拮抗死亡信号功能以及当在靶细胞中表达时促进细胞死亡。 本发明还考虑重组肽，多肽和蛋白质以及其包含p75 NTR的死亡信号传导部分的化学等同物，衍生物和同系物。 本发明特别有用的分子包含对应于p75 NTR的死亡信号传导部分的可溶形式的肽。 这些分子拮抗p75 NTR介导的细胞死亡。

公开(公告)号：US07919471B2

公开(公告)日：2011-04-05

申请号：US10921065

申请日：2004-08-18

申请人： Perry Francis Bartlett ,  Elizabeth Jane Coulson ,  Katrina Fieldew ,  Manuel Baca ,  Trevor Kilpatrick ,  Cheema Surindar

发明人： Perry Francis Bartlett ,  Elizabeth Jane Coulson ,  Katrina Fieldew ,  Manuel Baca ,  Trevor Kilpatrick ,  Cheema Surindar

IPC分类号： A61K48/00

CPC分类号： C07K14/70571 ,  A61K38/00 ,  A61K48/00

摘要： The present invention relates generally to a method for modulating cell survival. Modulation of cell survival includes inducing, enhancing or otherwise promoting cell survival such as the survival of neural cells as well as facilitating cell death such as the death of targeted cancer cells. The modulation of cell survival is mediated by a region identified on the p75 neurotrophin receptor (p75NTR) required for death signalling. The present invention further provides genetic molecules which encode the death signalling region of p75NTR which are useful in antagonising death signal function as well as promoting cell death when expressed in targeted cells. The present invention also contemplates recombinant peptides, polypeptides and proteins s well as chemical equivalents, derivatives and homologues thereof which comprise the death signalling portion of p75NTR. Particularly useful molecules of the present invention comprise peptides corresponding to soluble forms of the death signalling portion of p75NTR. These molecules antagonise p75NTR-mediated cell death.

摘要翻译： 本发明一般涉及调节细胞存活的方法。 细胞存活的调节包括诱导，增强或以其他方式促进细胞存活，例如神经细胞的存活以及促进细胞死亡，例如靶向癌细胞的死亡。 细胞存活的调节由死亡信号传导所需的p75神经营养因子受体（p75NTR）鉴定的区域介导。 本发明还提供编码p75NTR的死亡信号传导区的遗传分子，其可用于拮抗死亡信号功能以及当在靶细胞中表达时促进细胞死亡。 本发明还考虑重组肽，多肽和蛋白质以及其包含p75NTR的死亡信号传导部分的化学等同物，衍生物和同系物。 本发明特别有用的分子包含对应于p75NTR的死亡信号传导部分的可溶形式的肽。 这些分子拮抗p75NTR介导的细胞死亡。

公开(公告)号：US08299027B2

公开(公告)日：2012-10-30

申请号：US12885194

申请日：2010-09-17

申请人： Perry Francis Bartlett ,  Elizabeth Jane Coulson ,  Katrina Fieldew ,  Manuel Baca ,  Trevor Kilpatrick ,  Cheema Surindar

发明人： Perry Francis Bartlett ,  Elizabeth Jane Coulson ,  Katrina Fieldew ,  Manuel Baca ,  Trevor Kilpatrick ,  Cheema Surindar

IPC分类号： A61K38/18

CPC分类号： C07K14/70571 ,  A61K38/00 ,  A61K48/00

摘要： The present invention relates generally to a method for modulating cell survival. Modulation of cell survival includes inducing, enhancing or otherwise promoting cell survival such as the survival of neural cells as well as facilitating cell death such as the death of targeted cancer cells. The modulation of cell survival is mediated by a region identified on the p75 neurotrophin receptor (p75NTR) required for death signalling. The present invention further provides genetic molecules which encode the death signalling region of p75NTR which are useful in antagonising death signal function as well as promoting cell death when expressed in targeted cells. The present invention also contemplates recombinant peptides, polypeptides and proteins as well as chemical equivalents, derivatives and homologues thereof which comprise the death signalling portion of p75NTR. Particularly useful molecules of the present invention comprise peptides corresponding to soluble forms of the death signalling portion of p75NTR. These molecules antagonise p75NTR-mediated cell death.

摘要翻译： 本发明一般涉及调节细胞存活的方法。 细胞存活的调节包括诱导，增强或以其他方式促进细胞存活，例如神经细胞的存活以及促进细胞死亡，例如靶向癌细胞的死亡。 细胞存活的调节由死亡信号传导所需的p75神经营养因子受体（p75NTR）鉴定的区域介导。 本发明还提供编码p75NTR的死亡信号传导区的遗传分子，其可用于拮抗死亡信号功能以及当在靶细胞中表达时促进细胞死亡。 本发明还考虑了重组肽，多肽和蛋白质以及其包含p75NTR的死亡信号传导部分的化学等同物，衍生物和同系物。 本发明特别有用的分子包含对应于p75NTR的死亡信号传导部分的可溶形式的肽。 这些分子拮抗p75NTR介导的细胞死亡。

公开(公告)号：US20110172143A1

公开(公告)日：2011-07-14

申请号：US12885194

申请日：2010-09-17

申请人： Perry Francis Bartlett ,  Elizabeth Jane Coulson ,  Katrina Fieldew ,  Manuel Baca ,  Trevor Kilpatrick ,  Cheema Surindar

发明人： Perry Francis Bartlett ,  Elizabeth Jane Coulson ,  Katrina Fieldew ,  Manuel Baca ,  Trevor Kilpatrick ,  Cheema Surindar

IPC分类号： A61K38/00 ,  A61K38/16 ,  A61P25/28 ,  A61P25/00 ,  A61P25/02 ,  A61P13/12 ,  A61P31/22 ,  A61P25/16 ,  A61P35/00 ,  A61P31/12 ,  A61P31/18

CPC分类号： C07K14/70571 ,  A61K38/00 ,  A61K48/00

摘要： The present invention relates generally to a method for modulating cell survival. Modulation of cell survival includes inducing, enhancing or otherwise promoting cell survival such as the survival of neural cells as well as facilitating cell death such as the death of targeted cancer cells. The modulation of cell survival is mediated by a region identified on the p75 neurotrophin receptor (p75NTR) required for death signalling. The present invention further provides genetic molecules which encode the death signalling region of p75NTR which are useful in antagonising death signal function as well as promoting cell death when expressed in targeted cells. The present invention also contemplates recombinant peptides, polypeptides and proteins as well as chemical equivalents, derivatives and homologues thereof which comprise the death signalling portion of p75NTR. Particularly useful molecules of the present invention comprise peptides corresponding to soluble forms of the death signalling portion of p75NTR. These molecules antagonise p75NTR-mediated cell death.

摘要翻译： 本发明一般涉及调节细胞存活的方法。 细胞存活的调节包括诱导，增强或以其他方式促进细胞存活，例如神经细胞的存活以及促进细胞死亡，例如靶向癌细胞的死亡。 细胞存活的调节由死亡信号传导所需的p75神经营养因子受体（p75NTR）鉴定的区域介导。 本发明还提供编码p75NTR的死亡信号传导区的遗传分子，其可用于拮抗死亡信号功能以及当在靶细胞中表达时促进细胞死亡。 本发明还考虑了重组肽，多肽和蛋白质以及其包含p75NTR的死亡信号传导部分的化学等同物，衍生物和同系物。 本发明特别有用的分子包含对应于p75NTR的死亡信号传导部分的可溶形式的肽。 这些分子拮抗p75NTR介导的细胞死亡。

公开(公告)号：US20130079280A1

公开(公告)日：2013-03-28

申请号：US13640057

申请日：2011-04-12

申请人： Manuel Baca ,  Thomas Thisted ,  Jeffrey Swers

发明人： Manuel Baca ,  Thomas Thisted ,  Jeffrey Swers

IPC分类号： C07K19/00

CPC分类号： C07K19/00 ,  A61K2039/505 ,  C07K14/001 ,  C07K14/78 ,  C07K16/1027 ,  C07K16/2878 ,  C07K16/468 ,  C07K2317/73 ,  C07K2317/90 ,  C07K2318/20 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/33 ,  C07K2319/70 ,  C07K2319/74

摘要： The present invention provides fibronectin type III (Fn3)-based multimeric scaffolds that specifically bind to one or more specific target antigen. The invention further provides bispecific Fn3-derived binding molecules that bind to two or more target antigens simultaneously, fusions, conjugates, and methods to increase the stability of Fn3-based binding molecules. Furthermore, the present invention is related to a prophylactic, therapeutic or diagnostic agent, which contains Fn3-based multimeric scaffolds.

摘要翻译： 本发明提供了特异性结合一种或多种特异性靶抗原的基于纤连蛋白III（Fn3）的多聚体支架。 本发明还提供了同时结合两种或多种靶抗原的双特异性Fn3衍生结合分子，融合物，缀合物和增加Fn3基结合分子稳定性的方法。 此外，本发明涉及含有Fn3的多聚体支架的预防，治疗或诊断试剂。

公开(公告)号：US20100285035A1

公开(公告)日：2010-11-11

申请号：US12774966

申请日：2010-05-06

申请人： Andrew Donald Nash ,  Manuel Baca ,  Louis Jerry Fabri ,  Dennis Zaller ,  William R. Strohl ,  Zhiqiang An

发明人： Andrew Donald Nash ,  Manuel Baca ,  Louis Jerry Fabri ,  Dennis Zaller ,  William R. Strohl ,  Zhiqiang An

IPC分类号： A61K39/395 ,  C07K16/28 ,  C07H21/04 ,  A61P35/00 ,  A61P1/00 ,  A61P17/06 ,  A61P11/06 ,  A61P37/08 ,  A61P29/00 ,  A61P17/00 ,  C12N15/60 ,  C12N5/10

CPC分类号： C07K16/2866 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/43 ,  C12P21/005

摘要： High affinity antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are effective in the inhibition of IL-13Rα1-mediated activities and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with hIL-13Rα1 activity. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing IL-13Rα1-mediated activities are also disclosed.

摘要翻译： 公开了人白细胞介素-13受体α1的高亲和力抗体拮抗剂。 抗体分子在抑制IL-13Rα1介导的活性中是有效的，因此，在治疗与hIL-13Rα1活性相关的病症中使用所需的拮抗剂。 本发明还公开了编码所述抗体分子，载体，宿主细胞和包含抗体分子的组合物的核酸。 还公开了使用抗体分子抑制或拮抗IL-13Rα1介导的活性的方法。

公开(公告)号：US07683213B2

公开(公告)日：2010-03-23

申请号：US10558023

申请日：2004-05-25

申请人： Jean-Luc Dubois ,  Manuel Baca ,  Jean-Marc Millet

发明人： Jean-Luc Dubois ,  Manuel Baca ,  Jean-Marc Millet

IPC分类号： C07C51/16

CPC分类号： B01J23/28 ,  B01J23/002 ,  B01J23/18 ,  B01J23/20 ,  B01J27/0576 ,  B01J35/0006 ,  B01J2523/00 ,  C07C51/215 ,  C07C57/04 ,  B01J2523/55 ,  B01J2523/56 ,  B01J2523/64 ,  B01J2523/68 ,  B01J2523/53

摘要： The invention relates to a method for the production of acrylic acid from propane, in which a gas mixture comprising propane, water vapour and, optionally, an inert gas and/or molecular oxygen is passed over a catalyst, comprising a crystalline catalyst phase of formula (I) or (I′) TeaMolVbNbcOx (I) Sba Mol VbOy (I′), associated with a crystalline catalyst phase for activating the propane.

摘要翻译： 本发明涉及一种从丙烷生产丙烯酸的方法，其中将包含丙烷，水蒸汽和任选的惰性气体和/或分子氧的气体混合物通过催化剂，该催化剂包含式 （I）或（I'）TeaMolVbNbcOx（I）Sba Mol VbOy（I'），与用于活化丙烷的结晶催化剂相关。

公开(公告)号：US07517959B2

公开(公告)日：2009-04-14

申请号：US11598212

申请日：2006-11-09

申请人： Raymond Stanley Norton ,  Jeffrey James Babon ,  Sandra Elaine Nicholson ,  Nicos Anthony Nicola ,  Edward James McManus ,  Manuel Baca ,  Shenggen Yao

发明人： Raymond Stanley Norton ,  Jeffrey James Babon ,  Sandra Elaine Nicholson ,  Nicos Anthony Nicola ,  Edward James McManus ,  Manuel Baca ,  Shenggen Yao

IPC分类号： C07K14/46 ,  A61K38/17

CPC分类号： C07K14/4703 ,  A61K38/17

摘要： The present invention relates to the identification of a PEST motif in Suppressor of Cytokine Signalling (SOCS) proteins, the deletion/inactivation of which has been found to increase the stability of the protein whilst maintaining at least one biological activity of the protein. Such SOCS proteins with deleted/inactivated PEST motifs can be used in gene and protein therapy procedures to provide a more stable SOCS protein when compared to the native protein. The present invention also relates to the characterization of the structure of SOCS proteins, and methods of using this structural information to identify compounds which modulate the activity of SOCS.

摘要翻译： 本发明涉及鉴定细胞因子信号传导抑制因子（SOCS）蛋白质的抑制因子的PEST基序，已经发现其缺失/失活增加了蛋白质的稳定性，同时保持蛋白质的至少一种生物学活性。 具有缺失/失活的PEST基序的这种SOCS蛋白质可用于基因和蛋白质治疗程序，以便与天然蛋白质相比提供更稳定的SOCS蛋白质。 本发明还涉及SOCS蛋白质结构的表征，以及使用该结构信息鉴定调节SOCS活性的化合物的方法。

公开(公告)号：US20080166343A1

公开(公告)日：2008-07-10

申请号：US11875017

申请日：2007-10-19

申请人： Andrew Donald Nash ,  Manuel Baca ,  Louis Jerry Fabri ,  Dennis Zaller ,  William R. Strohl ,  Zhiqiang An

发明人： Andrew Donald Nash ,  Manuel Baca ,  Louis Jerry Fabri ,  Dennis Zaller ,  William R. Strohl ,  Zhiqiang An

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  A61P43/00

CPC分类号： C07K16/2866 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/43 ,  C12P21/005

摘要： High affinity antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are effective in the inhibition of IL-13Rα1-mediated activities and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with hIL-13Rα1 activity. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing IL-13Rα1-mediated activities are also disclosed.

摘要翻译： 公开了人白细胞介素-13受体α1的高亲和力抗体拮抗剂。 抗体分子在抑制IL-13Rα1介导的活性中是有效的，因此，在治疗与hIL-13Rα1活性相关的病症中使用所需的拮抗剂。 本发明还公开了编码所述抗体分子，载体，宿主细胞和包含抗体分子的组合物的核酸。 还公开了使用抗体分子抑制或拮抗IL-13Rα1介导的活性的方法。

公开(公告)号：US06884879B1

公开(公告)日：2005-04-26

申请号：US08908469

申请日：1997-08-06

申请人： Manuel Baca ,  James A. Wells

发明人： Manuel Baca ,  James A. Wells

IPC分类号： C12N15/02 ,  A61K38/00 ,  C07K16/18 ,  C07K16/22 ,  C12P21/08 ,  C07H21/04

CPC分类号： C07K16/22 ,  A61K38/00 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/73

摘要： Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.

摘要翻译： 公开了人源化和变异的抗VEGF抗体及其各种用途。 抗VEGF抗体对VEGF具有很强的结合亲和力; 体外抑制VEGF诱导的内皮细胞增殖; 并在体内抑制肿瘤生长。