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公开(公告)号：US09212231B2
公开(公告)日：2015-12-15
申请号：US13639381
申请日：2011-04-12
申请人： Manuel Baca , Thomas Thisted , Jeffrey Swers , David Tice
发明人： Manuel Baca , Thomas Thisted , Jeffrey Swers , David Tice
IPC分类号： C07K19/00 , C07K14/47 , C07K14/78 , C07K16/10 , C07K16/28 , C07K16/46 , C07K14/00 , C07K14/715 , A61K39/00
CPC分类号： C07K19/00 , A61K2039/505 , C07K14/001 , C07K14/78 , C07K16/1027 , C07K16/2878 , C07K16/468 , C07K2317/73 , C07K2317/90 , C07K2318/20 , C07K2319/00 , C07K2319/30 , C07K2319/33 , C07K2319/70 , C07K2319/74
摘要： The present invention provides Tenascin-3 FnIII domain-based multimeric scaffolds that specifically bind to TRAIL Receptor 2 (TRAIL R2), a cell membrane receptor involved in apoptosis. The invention further provides engineered variants with increased affinity for the target, increased stability, and reduced immunogenicity. Furthermore, the present invention is related to engineered multivalent scaffolds as prophylactic, diagnostic, or therapeutic agents, and their uses against diseases caused by cells expressing TRAIL R2, in particular to a therapeutic use against cancer.
摘要翻译： 本发明提供特异性结合参与凋亡的细胞膜受体TRAIL受体2（TRAIL R2）的基于腱生蛋白-3 FnIII结构域的多聚体支架。 本发明进一步提供了对目标具有增加的亲和力，增加的稳定性和降低的免疫原性的工程改造的变体。 此外，本发明涉及作为预防，诊断或治疗剂的工程化多价支架，以及它们对由表达TRAIL R2的细胞引起的疾病的用途，特别是抗癌治疗用途的用途。
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公开(公告)号：US20130096058A1
公开(公告)日：2013-04-18
申请号：US13639381
申请日：2011-04-12
申请人： Manuel Baca , Thomas Thisted , Jeffrey Swers , David Tice
发明人： Manuel Baca , Thomas Thisted , Jeffrey Swers , David Tice
IPC分类号： C07K14/00
CPC分类号： C07K19/00 , A61K2039/505 , C07K14/001 , C07K14/78 , C07K16/1027 , C07K16/2878 , C07K16/468 , C07K2317/73 , C07K2317/90 , C07K2318/20 , C07K2319/00 , C07K2319/30 , C07K2319/33 , C07K2319/70 , C07K2319/74
摘要： The present invention provides Tenascin-3 FnIII domain-based multimeric scaffolds that specifically bind to TRAIL Receptor 2 (TRAIL R2), a cell membrane receptor involved in apoptosis. The invention further provides engineered variants with increased affinity for the target, increased stability, and reduced immunogenicity. Furthermore, the present invention is related to engineered multivalent scaffolds as prophylactic, diagnostic, or therapeutic agents, and their uses against diseases caused by cells expressing TRAIL R2, in particular to a therapeutic use against cancer.
摘要翻译： 本发明提供特异性结合参与凋亡的细胞膜受体TRAIL受体2（TRAIL R2）的基于腱生蛋白-3 FnIII结构域的多聚体支架。 本发明进一步提供了对目标具有增加的亲和力，增加的稳定性和降低的免疫原性的工程改造的变体。 此外，本发明涉及作为预防，诊断或治疗剂的工程化多价支架，以及它们对由表达TRAIL R2的细胞引起的疾病的用途，特别是抗癌治疗用途的用途。
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公开(公告)号：US20130079280A1
公开(公告)日：2013-03-28
申请号：US13640057
申请日：2011-04-12
申请人： Manuel Baca , Thomas Thisted , Jeffrey Swers
发明人： Manuel Baca , Thomas Thisted , Jeffrey Swers
IPC分类号： C07K19/00
CPC分类号： C07K19/00 , A61K2039/505 , C07K14/001 , C07K14/78 , C07K16/1027 , C07K16/2878 , C07K16/468 , C07K2317/73 , C07K2317/90 , C07K2318/20 , C07K2319/00 , C07K2319/30 , C07K2319/33 , C07K2319/70 , C07K2319/74
摘要： The present invention provides fibronectin type III (Fn3)-based multimeric scaffolds that specifically bind to one or more specific target antigen. The invention further provides bispecific Fn3-derived binding molecules that bind to two or more target antigens simultaneously, fusions, conjugates, and methods to increase the stability of Fn3-based binding molecules. Furthermore, the present invention is related to a prophylactic, therapeutic or diagnostic agent, which contains Fn3-based multimeric scaffolds.
摘要翻译： 本发明提供了特异性结合一种或多种特异性靶抗原的基于纤连蛋白III（Fn3）的多聚体支架。 本发明还提供了同时结合两种或多种靶抗原的双特异性Fn3衍生结合分子，融合物，缀合物和增加Fn3基结合分子稳定性的方法。 此外，本发明涉及含有Fn3的多聚体支架的预防，治疗或诊断试剂。
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公开(公告)号：US09101565B2
公开(公告)日：2015-08-11
申请号：US13129664
申请日：2009-11-17
CPC分类号： A61K33/10 , A61J3/10 , A61K9/2018 , A61K9/2072 , A61K9/2095 , A61K9/282 , A61K33/06
摘要： The present invention relates to a method for the preparation of a tablet comprising at least 50% w/w of calcium carbonate, the method comprising i) providing a particulate composition comprising a) calcium carbonate, b) a binding sugar alcohol selected from sorbitol or isomalt, or combinations thereof, c) a non-binding sugar alcohol selected from mannitol, maltitol or xylitol, or combinations thereof, and ii) compressing said composition using a tabletting machine equipped with at least one pair of punches and dies, wherein the pair of punches and die before filling the die with said particulate composition is sprayed with a composition comprising a lubricant selected from magnesium stearate, calcium stearate or stearic acid or combinations thereof.
摘要翻译： 本发明涉及一种制备包含至少50％w / w碳酸钙的片剂的方法，所述方法包括i）提供包含a）碳酸钙的颗粒组合物，b）选自山梨醇或 异麦芽酮糖醇或其组合，c）选自甘露醇，麦芽糖醇或木糖醇的非结合性糖醇或其组合，以及ii）使用配备有至少一对冲头和模具的压片机压缩所述组合物，其中所述对 用含有选自硬脂酸镁，硬脂酸钙或硬脂酸的润滑剂或其组合的润滑剂的组合物喷涂用所述颗粒组合物填充模头之前的冲头和模具。
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公开(公告)号：US08617837B2
公开(公告)日：2013-12-31
申请号：US13455905
申请日：2012-04-25
CPC分类号： C12N9/2417 , C11D3/386 , C11D3/38618 , C12P7/06 , C12P7/14 , C12P19/14 , C12Y302/01001 , Y02E50/17
摘要： The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase.
摘要翻译： 本发明涉及亲本Termamyl样α-淀粉酶的变体（突变体），该变体具有α-淀粉酶活性并且相对于母体α-淀粉酶具有改变的性质。
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公开(公告)号：US08288144B2
公开(公告)日：2012-10-16
申请号：US12481922
申请日：2009-06-10
申请人： Sanne Schroder Glad , Carsten Andersen , Torben Vedel Borchert , Katja Salomon Johansen , Henrik Frisner , Mads Eskelund Bjornvad , Thomas Thisted
发明人： Sanne Schroder Glad , Carsten Andersen , Torben Vedel Borchert , Katja Salomon Johansen , Henrik Frisner , Mads Eskelund Bjornvad , Thomas Thisted
CPC分类号： C12N9/88 , C11D3/38636
摘要： The present invention relates to pectate lyase variants exhibiting alterations relative to a parent enzyme exhibiting pectate lyase activity as its major enzymatic activity; to a method of producing such enzymes; and to methods for using such enzymes in the textile, detergent and cellulose fiber processing industries. Compared to the parent enzyme, the pectate lyase variants of the present invention exhibit improved stability in detergents.
摘要翻译： 本发明涉及相对于显示出果胶裂解酶活性的亲本酶作为其主要酶活性的改变的果胶酸裂解酶变体; 涉及一种生产这种酶的方法; 以及在纺织，洗涤剂和纤维素纤维加工业中使用这些酶的方法。 与亲本酶相比，本发明的果胶酸裂解酶变体表现出改进的洗涤剂稳定性。
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公开(公告)号：US07727713B2
公开(公告)日：2010-06-01
申请号：US10175539
申请日：2002-06-20
申请人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
发明人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C12N15/1058 , C12P19/34 , C40B40/00
摘要： The present invention relates to a method for synthesizing templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
摘要翻译： 本发明涉及一种合成模板分子的方法。 在本发明的一个方面，模板分子连接到模板，其模板化其合成。 该内容允许生成可以被筛选的文库。 治疗活动。
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公开(公告)号：US08486681B2
公开(公告)日：2013-07-16
申请号：US12360635
申请日：2009-01-27
CPC分类号： C12N9/2417 , C11D3/386 , C11D3/38618 , C12P7/06 , C12P7/14 , C12P19/14 , C12Y302/01001 , Y02E50/17
摘要： The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase.
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公开(公告)号：US07611882B2
公开(公告)日：2009-11-03
申请号：US10478840
申请日：2002-05-14
申请人： Mads Eskelund Bjørnvad , Martin Schülein , Torben Henriksen, legal representative , Vibeke Skovgaard Nielsen , Johan Smets , Carsten Andersen , Thomas Thisted
发明人： Mads Eskelund Bjørnvad , Martin Schülein , Vibeke Skovgaard Nielsen , Johan Smets , Carsten Andersen , Thomas Thisted
CPC分类号： A61K8/66 , A61Q11/00 , C11D3/38636 , C12N9/88
摘要： Detergent composition comprising a surfactant and a pectate lyase (EC 4.2.2.2) enzyme en-coded by a DNA sequence endogeneous to a strain of Bacillus subtilis or a stabilized variant thereof provides superior cleaning and stain removal.
摘要翻译： 包含表面活性剂和由枯草芽孢杆菌菌株或其稳定变体的内切DNA序列编码的果胶酸裂解酶（EC 4.2.2.2）酶的洗涤剂组合物提供了优异的清洁和去污。
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10.发明申请公开(公告)号：US20090264300A1
公开(公告)日：2009-10-22
申请号：US12095778
申请日：2006-12-01
申请人： Thomas Franch , Mikkel Dybro Lundorf , Soren Nyboe Jacobsen , Eva Kampmann Olsen , Anne Lee Andersen , Anette Holtmann , Anders Holm Hansen , Anders Malling Sorensen , Anne Goldbech , Daen de Leon , Ditte Kievsmose Kaldor , Frank Abildgaard Slok , Gitte Nystrup Husemoen , Johannes Dolberg , Kim Birkebaek Jensen , Lene Pedersen , Mads Norregaard-Madsen , Michael Anders Godskesen , Sanne Schroder Glad , Sore Neve , Thomas Thisted , Tine Titilola Akinleminu Kronborg , Christian Klarner Sams , Jakob Felding , Per-Ola Freskgard , Alex Haahr Gouliaev , Henrik Pedersen
发明人： Thomas Franch , Mikkel Dybro Lundorf , Soren Nyboe Jacobsen , Eva Kampmann Olsen , Anne Lee Andersen , Anette Holtmann , Anders Holm Hansen , Anders Malling Sorensen , Anne Goldbech , Daen de Leon , Ditte Kievsmose Kaldor , Frank Abildgaard Slok , Gitte Nystrup Husemoen , Johannes Dolberg , Kim Birkebaek Jensen , Lene Pedersen , Mads Norregaard-Madsen , Michael Anders Godskesen , Sanne Schroder Glad , Sore Neve , Thomas Thisted , Tine Titilola Akinleminu Kronborg , Christian Klarner Sams , Jakob Felding , Per-Ola Freskgard , Alex Haahr Gouliaev , Henrik Pedersen
CPC分类号： C12N15/1068 , C12N15/1089 , C40B40/08 , C40B50/04 , C40B50/06
摘要： Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
摘要翻译： 公开了一种获得包含与单链标识符寡核苷酸连接的分子的双功能复合物的方法，其中包含化学反应位点的新生双功能复合物和用于酶标记添加的引发位点是a）在化学反应位点与 一种或多种反应物，和b）在起始位点用一种或多种标记反应物的标签进行酶促反应。
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