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公开(公告)号：US20180339060A1
公开(公告)日：2018-11-29
申请号：US16053344
申请日：2018-08-02
Applicant: PFIZER INC.
Inventor： Andreas MADERNA , Matthew David DOROSKI , Zecheng CHEN , Hud Lawrence RISLEY , Jeffrey Michael CASAVANT , Christopher John O'DONNELL , Alexander M. PORTE , Chakrapani SUBRAMANYAM
IPC: A61K47/68 , C07K9/00 , C07K5/06 , C07H17/02 , C07F9/6561 , C07D487/04 , C07D417/14 , C07D409/14 , C07D405/14 , C07D401/14 , A61K38/06 , A61K38/05 , A61K31/7056 , A61K31/675 , A61K31/454 , A61K31/4439 , A61K31/433 , A61K31/407 , A61K31/404 , C07K5/08
CPC classification number: A61K47/6851 , A61K31/404 , A61K31/407 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/675 , A61K31/7056 , A61K38/05 , A61K38/06 , A61K47/6803 , A61K47/6807 , A61K47/6811 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D487/04 , C07F9/6561 , C07H17/02 , C07K5/06 , C07K5/08 , C07K9/003
Abstract: Cytotoxic dimers comprising CBI-based and/or CPI-based sub-units, antibody drug conjugates comprising such dimers, and to methods for using the same to treat cancer and other conditions.
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公开(公告)号：US20210308276A1
公开(公告)日：2021-10-07
申请号：US16321695
申请日：2017-07-31
Applicant: PFIZER INC.
Inventor： Russell George DUSHIN , Daniel P. UCCELLO , Jeremy STARR , Ye CHE , Mark FLANAGAN , Jeffrey M. CASAVANT , Christopher John O'DONNELL , Gary Frederick FILZEN , Jennifer YOUNG , Joseph A. ABRAMITE , Lawrence N. TUMEY , Ludivine MOINE , Adam Matthew GILBERT , Lee R. ROBERTS
IPC: A61K47/68
Abstract: The present invention is directed to novel heteroaryl sulfone-based conjugation handles of the formula: (wherein R1, R2, Het, D, E, X, Y, Z, m, n, p, q, r, s and t are as defined herein), methods for their preparation, their use in synthesizing antibody drig conjugates, and the resulting antibody drig conjugates made with components having heteroaryl sulfone-based conjugation handles.
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3.发明申请公开(公告)号：US20170014523A1
公开(公告)日：2017-01-19
申请号：US15280563
申请日：2016-09-29
Applicant: PFIZER INC.
Inventor： Chakrapani SUBRAMANYAM , Frank Erich KOEHN , Kenneth John DIRICO , Alessandra S. EUSTAQUIO , Michael Eric GREEN , Haiyin HE , Min HE , Christopher John O'DONNELL , Sujiet PUTHENVEETIL , Anokha RATNAYAKE , Jesse Alexander TESKE , Hui Yu YANG
IPC: A61K47/48 , A61K31/453 , A61K31/4025 , A61K31/351 , A61K31/501 , A61K31/35 , A61K31/496
CPC classification number: A61K47/6855 , A61K31/35 , A61K31/351 , A61K31/397 , A61K31/4025 , A61K31/453 , A61K31/496 , A61K31/501 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07D309/10 , C07D309/14 , C07D405/12 , C07D405/14 , C07D493/10 , C07D493/20
Abstract: The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
Abstract translation: 本发明涉及新颖的细胞毒素剪接抑制物类似物及其衍生物，其抗体药物偶联物及其用于治疗包括癌症在内的医学病症的方法。
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Patent Agency Ranking
公开(公告)号：US20150209445A1
公开(公告)日：2015-07-30
申请号：US14605697
申请日：2015-01-26
Applicant: Pfizer Inc.
Inventor： Andreas MADERNA , Matthew David DOROSKI , Zecheng CHEN , Hud Lawrence RISLEY , Jeffrey Michael CASAVANT , Christopher John O'DONNELL , Alexander M. PORTE , Chakrapani SUBRAMANYAM
IPC: A61K47/48 , A61K31/404 , A61K31/4439 , C07D401/14 , C07D409/14 , A61K31/675 , C07F9/6561 , A61K31/454 , A61K31/7056 , C07H17/02 , C07D417/14 , A61K31/433 , A61K31/407 , C07D487/04 , C07K5/08 , C07K5/06 , C07K9/00 , A61K38/05 , A61K38/06 , C07D405/14
CPC classification number: A61K47/48384 , A61K31/404 , A61K31/407 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/675 , A61K31/7056 , A61K38/05 , A61K38/06 , A61K47/6803 , A61K47/6807 , A61K47/6811 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D487/04 , C07F9/6561 , C07H17/02 , C07K5/06 , C07K5/08 , C07K9/003
Abstract: Cytotoxic dimers comprising CBI-based and/or CPI-based sub-units, antibody drug conjugates comprising such dimers, and to methods for using the same to treat cancer and other conditions.
Abstract translation: 包含基于CBI和/或CPI的亚单位的细胞毒性二聚体，包含这种二聚体的抗体药物偶联物，以及使用该二聚体治疗癌症和其它病症的方法。
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公开(公告)号：US20140134193A1
公开(公告)日：2014-05-15
申请号：US14069057
申请日：2013-10-31
Applicant: PFIZER INC.
Inventor： Chakrapani SUBRAMANYAM , Frank Erich KOEHN , Kenneth John DIRICO , Alessandra S. EUSTAQUIO , Michael Eric GREEN , Haiyin HE , Min HE , Christopher John O'DONNELL , Sujiet PUTHENVEETIL , Anokha RATNAYAKE , Jesse Alexander TESKE , Hui Yu YANG
IPC: C07D493/10 , A61K47/48 , A61K45/06 , C07D309/14 , C07D405/14
CPC classification number: A61K47/6855 , A61K31/35 , A61K31/351 , A61K31/397 , A61K31/4025 , A61K31/453 , A61K31/496 , A61K31/501 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07D309/10 , C07D309/14 , C07D405/12 , C07D405/14 , C07D493/10 , C07D493/20
Abstract: The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
Abstract translation: 本发明涉及新颖的细胞毒素剪接抑制物类似物及其衍生物，其抗体药物偶联物及其用于治疗包括癌症在内的医学病症的方法。
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公开(公告)号：US20130129753A1
公开(公告)日：2013-05-23
申请号：US13670612
申请日：2012-11-07
Applicant: PFIZER INC.
Inventor： Matthew David DOROSKI , Andreas MADERNA , Christopher John O'DONNELL , Chakrapani SUBRAMANYAM , Beth VETELINO , Russell George DUSHIN , Pavel STROP , Edmund Idris GRAZIANI
CPC classification number: C07K7/06 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/6803 , A61K47/6811 , A61K47/6851 , A61K47/6855 , A61K47/6863 , A61K47/6889 , C07K5/0205 , C07K5/0808 , C07K7/02 , C07K16/00 , C07K2319/30
Abstract: The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.
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公开(公告)号：US20150307551A1
公开(公告)日：2015-10-29
申请号：US14793942
申请日：2015-07-08
Applicant: PFIZER INC.
Inventor： Matthew David DOROSKI , Andreas MADERNA , Christopher John O'DONNELL , Chakrapani SUBRAMANYAM , Beth VETELINO , Russell George DUSHIN , Pavel STROP , Edmund Idris GRAZIANI
IPC: C07K7/06
CPC classification number: C07K7/06 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/6803 , A61K47/6811 , A61K47/6851 , A61K47/6855 , A61K47/6863 , A61K47/6889 , C07K5/0205 , C07K5/0808 , C07K7/02 , C07K16/00 , C07K2319/30
Abstract: The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.
Abstract translation: 本发明涉及细胞毒性五肽，其抗体药物偶联物及其用于治疗癌症的方法。
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公开(公告)号：US20140363452A1
公开(公告)日：2014-12-11
申请号：US14322262
申请日：2014-07-02
Applicant: PFIZER INC.
Inventor： Matthew David DOROSKI , Andreas MADERNA , Christopher John O'DONNELL , Chakrapani SUBRAMANYAM , Beth VETELINO , Russell George DUSHIN , Pavel STROP , Edmund Idris GRAZIANI
CPC classification number: C07K7/06 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/6803 , A61K47/6811 , A61K47/6851 , A61K47/6855 , A61K47/6863 , A61K47/6889 , C07K5/0205 , C07K5/0808 , C07K7/02 , C07K16/00 , C07K2319/30
Abstract: The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.
Abstract translation: 本发明涉及细胞毒性五肽，其抗体药物偶联物及其用于治疗癌症的方法。
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