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    Intra-aortic renal drug delivery catheter
    4.
    发明授权
    Intra-aortic renal drug delivery catheter 有权
    主动脉内肾脏药物输送导管

    公开(公告)号：US07329236B2

    公开(公告)日：2008-02-12

    申请号：US11221679

    申请日：2005-09-07

    申请人： Randy J. Kesten ,  Michael H. Rosenthal ,  Sam G. Payne ,  Andrew W. Kramer ,  Sophia Pesotchinsky

    发明人： Randy J. Kesten ,  Michael H. Rosenthal ,  Sam G. Payne ,  Andrew W. Kramer ,  Sophia Pesotchinsky

    IPC分类号： A61M29/00

    CPC分类号： A61M25/1002 ,  A61M2025/0034 ,  A61M2025/0035 ,  A61M2025/0036 ,  A61M2025/0037 ,  A61M2025/0039 ,  A61M2025/004 ,  A61M2025/1004 ,  A61M2025/105 ,  A61M2025/1059 ,  A61M2025/1084

    摘要： A catheter for delivering a therapeutic or diagnostic agent to a branch blond vessel of a major blood vessel comprises an elongated shaft having at least one lumen in fluid communication with an agent delivery port in a distal section of the shaft, an expandable tubular member on the distal section of the shaft, and a radially expandable member on the tubular member. The tubular member is configured to extend within the blood vessel up-stream and down-stream of a branch vessel, and has an interior passageway which is radially expandable within the blood vessel to separate blood flow through the blood vessel into an outer blood flow stream exterior to the tubular member and an inner blood flow stream within the interior passageway of the tubular member.

    摘要翻译： 用于将治疗剂或诊断剂递送到主要血管的分支金黄色血管的导管包括细长轴，其具有至少一个内腔，其与所述轴的远侧部分中的药剂输送端口流体连通，所述可扩张管状构件 所述轴的远端部分和所述管状部件上的径向可扩张部件。 管状构件构造成在分支容器的上游和下游的血管内延伸，并且具有在血管内可径向扩张的内部通道，以将通过血管的血液分离成外部血流 管状构件的外部和管状构件的内部通道内的内部血流。

    Intra-aortic renal drug delivery catheter
    6.
    发明授权
    Intra-aortic renal drug delivery catheter 失效
    主动脉内肾脏药物输送导管

    公开(公告)号：US07122019B1

    公开(公告)日：2006-10-17

    申请号：US09724691

    申请日：2000-11-28

    申请人： Randy J. Kesten ,  Michael H. Rosenthal ,  Sam G. Payne ,  Andrew K. Kramer ,  Sophia Pesotchinsky

    发明人： Randy J. Kesten ,  Michael H. Rosenthal ,  Sam G. Payne ,  Andrew K. Kramer ,  Sophia Pesotchinsky

    IPC分类号： A61M31/00 ,  A61M29/00 ,  A61M37/00 ,  A61N1/362

    CPC分类号： A61M25/10 ,  A61M2025/0037

    摘要： A catheter for delivering a therapeutic or diagnostic agent to a branch blood vessel of a major blood vessel, generally comprising an elongated shaft having at least one lumen in fluid communication with an agent delivery port in a distal section of the shaft, an expandable tubular member on the distal section of the shaft, and a radially expandable member on the tubular member. The tubular member is configured to extend within the blood vessel up-stream and down-stream of a branch vessel, and has an interior passageway which is radially expandable within the blood vessel to separate blood flow through the blood vessel into an outer blood flow stream exterior to the tubular member and an inner blood flow stream within the interior passageway of the tubular member. The radially expandable member is located down-stream of the shaft agent delivery port, and has an expanded configuration with an outer diameter larger than an outer diameter of the tubular member. The expanded radially expandable member is configured to decrease the blood flow in the outer blood flow stream down-stream of the branch vessel. The catheter provides for delivery of an agent to a branch vessel of a major vessel, and continuous perfusion of the major blood vessel. Another aspect of the invention is directed to methods of delivering a therapeutic or diagnostic agent to one or both kidney's of a patient.

    摘要翻译： 一种用于将治疗剂或诊断剂递送到主要血管的分支血管的导管，通常包括细长轴，所述细长轴具有与所述轴的远端部分中的药剂输送端口流体连通的至少一个内腔， 在所述轴的远侧部分上，以及在所述管状构件上的径向可扩张构件。 管状构件构造成在分支容器的上游和下游的血管内延伸，并且具有在血管内可径向扩张的内部通道，以将通过血管的血液分离成外部血流 管状构件的外部和管状构件的内部通道内的内部血流。 径向可膨胀构件位于轴剂输送口的下游，并且具有外径大于管状构件的外径的膨胀构型。 扩张的可径向扩张的构件被配置为减小分支容器下游的外部血液流中的血流。 导管提供将药剂递送到主血管的分支血管，并连续灌注主血管。 本发明的另一方面涉及将治疗剂或诊断剂递送到患者的一种或两种肾脏的方法。

    Intracorporeal device with radiopaque marker
    10.
    发明授权
    Intracorporeal device with radiopaque marker 失效
    具有不透射线标记的体内器械

    公开(公告)号：US06285903B1

    公开(公告)日：2001-09-04

    申请号：US09107843

    申请日：1998-06-30

    申请人： Michael H. Rosenthal ,  Manuel A. Javier, Jr. ,  Sam G. Payne ,  Stephen B. Pearce ,  Randy J. Kesten

    发明人： Michael H. Rosenthal ,  Manuel A. Javier, Jr. ,  Sam G. Payne ,  Stephen B. Pearce ,  Randy J. Kesten

    IPC分类号： A61B505

    CPC分类号： A61M25/0108 ,  A61B6/12 ,  A61B90/39

    摘要： An intracorporeal device generally having an elongate shaft with an asymmetric radiopaque marker disposed upon or within the distal end thereof. The radiopaque marker member enables the user to determine the orientation of the distal end of the device under fluoroscopic and similar imaging techniques. In certain embodiments the device is configured as a delivery catheter system having multiple delivery catheters, some or all of which may have radiopaque marker members disposed upon or within their distal ends. The delivery catheter system is configured in some embodiments to deliver an elongated diagnostic or therapeutic device to a desired location within a patient's heart.

    摘要翻译： 体内装置通常具有设置在其远端上或其远端内的具有不对称不透射线标记的细长轴。 不透射线的标记构件使得用户能够在荧光镜和类似成像技术下确定装置的远端的取向。 在某些实施例中，该装置被配置为具有多个输送导管的递送导管系统，其中一些或全部可具有设置在其远端上或其远端内的不透射线的标记构件。 输送导管系统在一些实施例中被配置以将细长的诊断或治疗装置递送到患者心脏内的期望位置。